Echocardiographic Epicardial Fat Thickness and Coronary Artery Disease

Jeong, Jaehoon; Jeong, Myung Ho; Yun, Kyeong Ho; Oh, Seok Kyu; Park, Eun Mi; Kim, Yun Kyung; Rhee, Sang Hoon; Lee, Eun Mi; Lee, Je; Yoo, Nam Jin; Kim, Nam-Ho; Park, Jong Chun

doi:10.1253/circj.71.536

Cited by 333 publications

(298 citation statements)

References 18 publications

Supporting

Mentioning

249

Contrasting

Unclassified

Order By: Relevance

“…This point was in contrast with the findings of a study undertaken by Mookadam et al However, it seems that age was a noteworthy confounding variable in the aforementioned study (12). We also could not establish a relation between the amount of EFT and extent of coronary involvement, as opposed to several other studies, that have proposed an association between EFT and severity of CAD (4,5). This issue might be explained, based on different baseline characteristics across various study populations and the age, as an important variable affecting the expansion of atherosclerosis, which was also mentioned in Jeong study (4).…”

Section: Discussioncontrasting

confidence: 74%

Association between epicardial fat thickness and premature coronary artery disease: A case control study

et al. 2015

View full text Add to dashboard Cite

Background:The association between epicardial fat thickness (EFT) and premature coronary artery disease (CAD) has not been elaborately studied. Objectives: In the present study, we sought whether such a relationship between EFT and CAD exists. Patients and Methods: Sixty two consecutive subjects, under 50 years of age, who underwent coronary angiography (CAG) with the aspect of CAD, were included in this case control study. They were divided into two groups of 31 subjects, namely CAD (cases) and non-CAD (controls) group, according to CAG data. Presence of conventional coronary risk factors, drug history, and anthropometric data were recorded. Then, each subject underwent standard transthoracic echocardiography for measuring EFT in the proximal part of right ventricular outflow tract in the parasternal long axis view at end diastole, as well as other parameters of systolic and diastolic function, and left ventricle (LV) mass. Images were stored for offline analysis when the echocardiocardiographers were blind to CAG data. Results: Among baseline characteristics, waist circumference, triglyceride levels, cigarette smoking and history of statin use were significantly higher in the CAD group. The body mass index (BMI) was significantly higher in the non-CAD group. According to echocardiographic data, the EFT with a cut off value of 2.95 mm could well differentiate subjects in each group. The LV mass and E/e were significantly higher in CAD group, in addition to EFT. Also, there was a significant correlation between EFT and waist circumference, as well as LV mass. However, no significant relation was between EFT and LV systolic and diastolic function. Conclusions:The EFT, as measured by echocardiography, with a cut off value 2.95 mm has a strong association with premature CAD.

show abstract

Section: Discussioncontrasting

confidence: 74%

Association between epicardial fat thickness and premature coronary artery disease: A case control study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…We showed that echocardiographic assessment of epicardial adipose tissue can serve as a new index of cardiac and visceral adiposity. We also previously demonstrated that epicardial fat is clinically correlated with magnetic resonance imaging abdominal visceral adiposity (7), coronary artery disease (8,9), atherosclerosis (10,11), and major anthropometric and metabolic predictors of increased cardiometabolic risk (12)(13)(14). Emerging evidences suggest that epicardial fat may act as therapeutic target during therapeutic interventions modulating the adipose tissue (15).…”

Section: Introductionmentioning

confidence: 93%

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Iacobellis

Singh

Wharton

et al. 2008

Obesity

208

164

View full text Add to dashboard Cite

We sought to evaluate the effect of weight loss on echocardiographic epicardial fat thickness, as index of visceral adiposity, and whether epicardial fat change after the weight loss can be proportionally different from overall body weight changes and related to cardiac parameters changes in severely obese subjects. This was an interventional study in 20 severely obese subjects (12 women, 8 men, BMI 45 ± 5 kg/m 2 , 35 ± 10 years) who underwent 6-month very low calorie diet weight loss program. Baseline and after 6-month weight loss anthropometrics, echocardiographic epicardial fat thickness, left ventricular mass (LVM), and diastolic function parameters were assessed. Subjects lost 20% of original body weight, BMI reduced by 19% of original BMI, waist circumference decreased by 23% of initial waist circumference. Epicardial fat thickness decreased from 12.3 ± 1.8 to 8.3 ± 1 mm P < 0.001 after the 6-month very low calorie diet, as −32% of baseline epicardial fat thickness. LVM and diastolic function changes were better correlated with epicardial fat changes. We showed that significant weight loss can be associated with significant reduction in the epicardial fat thickness, marker of visceral adiposity in severely obese subjects. Epicardial fat decrease, therefore visceral fat decrease, can be proportionally higher than overall adiposity decrease. Epicardial fat changes are significantly associated with obesity-related cardiac morphological and functional changes during weight loss. Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution.

show abstract

“…In CAD, the extent of EAT accumulation is associated with disease severity, and perivascular adipocytes are known to secrete inflammatory cytokines [4,[11][12][13][14]. The presence of inflammation in pericardial fat results in a higher density in computed tomography (CT) images and is correlated with culprit lesions in patients with CAD [15].…”

Section: Introductionmentioning

confidence: 99%

Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation

Kusayama

Furusho

Kashiwagi

et al. 2016

Journal of Cardiology

View full text Add to dashboard Cite

Echocardiographic Epicardial Fat Thickness and Coronary Artery Disease

Cited by 333 publications

References 18 publications

Association between epicardial fat thickness and premature coronary artery disease: A case control study

Association between epicardial fat thickness and premature coronary artery disease: A case control study

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation

Contact Info

Product

Resources

About