Echocardiographic evaluation of left ventricular mass index in children with hypospadias after hormonal stimulation with topical testosterone: A randomized controlled trial

Andrade, Elisabeth Campos de; Paiva, Kelly Christina de Castro; Guedes, Sarah da Silva; Souza, M L; Pereira, Marina Novellino; Miana, Laura Pimenta; Figueiredo, André Avarese de; Bessa, José de; Netto, José Murillo Bastos

doi:10.1016/j.jpurol.2017.03.019

Cited by 4 publications

(6 citation statements)

References 30 publications

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“…The studies included in the analysis showed no serious adverse events, despite the risk of pubic hair growth and genital pigmentation in the studies by Paiva et al, Asgari et al, and Mohammadipour et al (14,15,19). de Andrade et al reported that preoperative testosterone stimulation resulted in an increase in serum testosterone concentrations up to 30 days after discontinuation of therapy, and could result in a mild rise in systolic blood pressure (17).…”

Section: Side Effectsmentioning

confidence: 96%

“…Gorduza et al reported 300 cases of "severe hypospadias" in 2011, and another series of 241 cases in 2020, although these cases were not further classified (7,8). Babu (17)(18)(19).…”

Section: Types Of Hypospadiasmentioning

confidence: 99%

“…Casali et al investigated the effect of the same regimen on the epidermal thickness and type I collagen expression, both of which were found to be significantly increased compared with the control group (10). de Andrade et al reported the use of topical testosterone propionate for 30 days, which resulted in increased serum testosterone concentrations up to 30 days post-therapy (17). There are four studies using testosterone enanthate as a preoperative intervention.…”

Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

“…There is no consensus about the preparation and dosage of hormonal therapy in hypospadias, and the available data are empirical studies that cannot support any one therapeutic regimen. Preoperative DHT treatment was reported in studies by Kaya et (16,18,21), although the duration of use of topical therapy was only reported in the study by de Andrade et al (30 days) (17). Parenteral testosterone in the included study was administered in the intramuscular preparation of testosterone enanthate.…”

Section: Dose and Formulationmentioning

confidence: 99%

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Preoperative hormonal stimulation in hypospadias: a systematic review

Pramono¹,

Siregar²,

Sibarani³

2023

Ann Afr Surg.

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Introduction: Preoperative hormonal stimulation with testosterone or estrogen is an emerging treatment modality for hypospadias, which can potentially improve surgical outcomes and reduce the risk of complications. This review aims to evaluate the current knowledge on preoperative hormonal stimulation in hypospadias. Methods: This study was a combination of a systematic review followed by a meta-regression analysis performed on PubMed, Google Scholar, DOAJ, and Cochrane. The study included randomized controlled trials, prospective and retrospective cohort studies, and before-and-after studies with or without control. The search was performed in English and was limited to articles published between January 1, 2000, and December 31, 2020. Results: The database search yielded 188 articles, which were systematically eliminated, leaving 15 relevant articles. The analyzed articles showed that testosterone is the most commonly used hormonal treatment in hypospadias, followed by dihydrotestosterone (DHT) and estrogen. Testosterone may be given in topical, parenteral, or oral formulations, while DHT is most often used in topical form. Conclusions: Preoperative stimulation with testosterone or DHT is associated with increased penile length and glans circumference before surgery, which may ease the reconstruction process. In addition, testosterone and DHT increase the rate of neovascularization and reduce the risk of postoperative complications.

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Section: Side Effectsmentioning

confidence: 96%

“…Gorduza et al reported 300 cases of "severe hypospadias" in 2011, and another series of 241 cases in 2020, although these cases were not further classified (7,8). Babu (17)(18)(19).…”

Section: Types Of Hypospadiasmentioning

confidence: 99%

Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

Section: Dose and Formulationmentioning

confidence: 99%

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Preoperative hormonal stimulation in hypospadias: a systematic review

Pramono¹,

Siregar²,

Sibarani³

2023

Ann Afr Surg.

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“…Urethral closure depends on the transformation of testosterone into dihydrotestosterone (DHT) (anabolic steroid of 5α-reductase type II), binding of DHT ligand with nuclear apparatus of androgen and the following respective androgen receptors activities (AR). The last two studies highlighted the influence of progesterone on the increase in the risk of hypospadias development(Carmichael et al, 2012;de Andrade et al, 2017;Wilkinson et al, 2017;Wong et al, 2018;Wu et al, 2018).…”

mentioning

confidence: 99%

The Ways of Improvement of the Methods of Hypospadias Treatment in Children: Literature Review

Zharkimbayeva¹,

Dyusembayev²,

Аубакиров³

et al. 2019

PTQ

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The relevance of the study is due to the fact that hypospadias is a congenital defect of the urogenital system in boys. The incidence rate of hypospadias differs in different countries. The main etiological factor of this defect development is a hormonal imbalance of different origin in mothers. Hypospadias can be corrected only surgically. Currently, there are a number of surgical approaches used, but still, the number of complications in the postoperative period remains high. The purpose of the article was to evaluate the outcomes of surgical correction of hypospadias in children observed after different approaches to urethroplasty involving transplanting. The authors performed a search for articles in electronic databases Pub Med, Elsevier, Scopus, Web of Science for the period from 2007 to 2018. The authors reviewed 265 articles dedicated to the correction of hypospadias by the following methods: TIP (tabularized incised plate), Mathieu, GTIP (graft tabularized incised plate) and two-stage Bracka urethroplasty. The most widespread complications mentioned in different studies were fistulas, stenosis of the urethral neo-meatus, and secondary deformation of the penis. Current approaches to surgical correction of hypospadias in children do not provide complete recovery from post-operative complications. Due to this fact, the issues of treatment of hypospadias remain relevant, requiring the development of new approaches to urethroplasty.

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