Echocardiographic parameters associated with recovery in heart failure with reduced ejection fraction

Shah, Muhammad Azam; Soofi, Muhammad; Jafary, Zainab M.; Alhomrani, Ashwaq; Alsmadi, Faisal; Wani, Tariq Ahmad; Bajwa, Iftikhar Ahmad

doi:10.1111/echo.14859

Cited by 11 publications

(11 citation statements)

References 24 publications

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“…No additional studies were added through the manual search. Therefore, a total of 18 studies were included in the meta-analysis [ 3 , 8 , 11 , 14 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. The PRISMA flow diagram is demonstrated in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 18 cohort studies from 2011 to 2021 were included in our meta-analysis with a total population of 12,270 patients (3460, 28.2% female) [ 3 , 8 , 11 , 14 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. There were 4, 13, and 1 studies that used an LVEF cutoff value of >50%, >40–45%, and >35% for LVEF recovery, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Female Gender Is Associated with an Increased Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure with Reduced Ejection Fraction

et al. 2022

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We performed a systematic review and meta-analysis to evaluate the association whether the female gender was associated with an increased chance of left ventricular ejection fraction (LVEF) in patients with heart failure with reduced ejection fraction (HFrEF). We searched the databases of MEDLINE and EMBASE from inception to 18 January 2022. Included studies were published studies evaluating or reporting characteristics of patients with HF with recovered LVEF. Data from each study were combined using a random-effects model, the generic inverse variance method of DerSimonian and Laird, to calculate odd ratios (OR) and 95% confidence intervals (CI). Eighteen studies were included in the analysis with a total of 12,270 patients (28.2% female). Female gender was associated with an increased chance of LVEF recovery (pooled OR = 1.50, 95% CI = 1.21–1.86, p-value < 0.001, I2 = 74.5%). In our subgroup analysis, female gender was associated with an increased chance of LVEF recovery when defined as LVEF > 50% (pooled OR = 1.78, 95% CI = 1.45–2.18, p-value < 0.001, I2 = 0.0%), and LVEF > 40–45% (pooled OR = 1.45, 95% CI = 1.09–1.91, p-value = 0.009, I2 = 79.2%), but not in LVEF > 35 (OR = 2.18, 95% CI = 0.94–5.05, p-value = 0.06). Our meta-analysis demonstrated that the female gender is associated with an increased chance of LVEF recovery. This association was not statistically significant in the subgroup that defined LVEF recovery as LVEF > 35%.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Female Gender Is Associated with an Increased Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure with Reduced Ejection Fraction

et al. 2022

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“…В ходе проведенного исследования были получены мало ожидаемые результаты, указывающие на более выраженную структурную перестройку левых отделов сердца у больных ДКМП. Считается, что увеличение размеров ЛЖ ассоциируется с худшим про гнозом [15] и меньшей вероятностью восстановления утраченных функций сердца [16]. Крупный метаанализ, проведенный в 2019г (14939 больных c ФП и 50720 пациентов без ФП), продемонстрировал сильные связи между диаметром и объемом ЛП и неблагоприятными событиями: декомпенсацией ХСН и смертью [17].…”

Section: Discussionunclassified

Echocardiographic characteristics of patients with ischemic and non-ischemic chronic heart failure with reduced ejection fraction

Ilov

Stompel

Boytsov

et al. 2022

Cardiovasc Ther Prev

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TThe data indicate differences in the adverse outcomes of chronic heart failure (CHF) in both ischemic (ICMP) and non-ischemic origins. The knowledge of the structural and functional myocardial state, especially of the left ventricle (LV), is insufficient for accurate risk stratification of unfavorable events in different etiopathogenetic forms of CHF.Aim. To make a comparative analysis of echocardiographic characteristics of CHF patients with reduced LV ejection fraction (EF) ≤35% depending on the origin of CHF.Material and methods. 498 patients of CHF 3-4 functional class of NYHA (New-York Heart Association) with EF ≤35% taking optimal drug therapy were included in the study. Based on the etiology of CHF, two groups of patients with CHF of ischemic genesis (n=254) and dilated cardiomyopathy (DCMP, n=244) were formed. Two-dimensional echocardiography techniques in Band M-mode, color Doppler, and tissue Doppler imaging were carried out.Results. Patients with ICMP and DCMP had the same pattern of LV remodeling (mainly on the type of eccentric hypertrophy), but they reliably differed in the basic parameters of LV architectonics: endsystolic and end-diastolic dimensions, LV volume, LV myocardial mass and values of these indicators, indexed by body surface area. DCMP patients had a higher value of medial-lateral dimension and volume of left atrial, pathological mitral and tricuspid regurgitation was registered more often.Conclusion. It was found that left heart dimensions and volumes of DCMP patients exceed similar parameters in patients with ICMP. The possible association of the results with future adverse outcomes of CHF demands further research.

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“…In two recent large, retrospective analyses of patients with heart failure, 38% and 34% of patients had recovery of their EF (defined as improvement > 10%) after a waiting period of at least 6 months or 9 weeks, respectively, which is similar to the rate of recovery in our population [ 4 , 5 ]. Previous studies have identified several factors associated with EF recovery, including female sex, younger age, nonischemic cardiomyopathy, lower baseline EF, left ventricle end-diastolic volume, and tricuspid annular plane systolic excursion (TAPSE) [ 4 - 6 ]. The failure to identify any significant factor aside from initial EF in predicting recovery in this study may have been related to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

Rate of Recovery of Left Ventricular Ejection Fraction in a Real-World Population of Patients Receiving a Wearable Cardioverter Defibrillator

et al. 2021

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Background This study aimed to investigate the rate of early improvement in ejection fraction (EF) within 21 - 60 days among patients with cardiomyopathy who were provided with a wearable cardioverter defibrillator (WCD). Methods This was a retrospective study of patients who received a WCD at our institution to determine the rate of improvement in left ventricular EF (LVEF) to ≥ 35-40%. Among 990 patients who received a WCD during the study period, 101 had an echocardiogram performed during the subsequent 21 - 60 days. Patients were stratified according to their initial EF, as well as age, gender, number of heart failure medications, and ischemic vs. nonischemic cardiomyopathy. Multivariate logistic regression analysis was performed to assess the influence of these variables on the subsequent improvement in EF. Results There were 39 patients who had improvement in their EF to ≥ 35-40%. The only significant predictor of EF recovery was the initial EF. There was a direct correlation between initial EF category and the likelihood of improvement in EF. For every unit increase in initial EF category, the odds of improvement increased 1.73 times (95% confidence interval (CI): 1.22 - 2.45). Age (P = 0.20), gender (P = 0.10), ischemic cardiomyopathy (P = 0.40), and number of heart failure medications at the time of WCD placement (P = 0.26) were not significant predictors of improved LVEF. Conclusions This study showed a rate of improvement in EF to ≥ 35-40% of 39% within 21 - 60 days of placement of a WCD among patients with both ischemic and nonischemic cardiomyopathy. The only significant clinical predictor of EF improvement was initial EF.

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Echocardiographic parameters associated with recovery in heart failure with reduced ejection fraction

Cited by 11 publications

References 24 publications

Female Gender Is Associated with an Increased Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure with Reduced Ejection Fraction

Female Gender Is Associated with an Increased Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure with Reduced Ejection Fraction

Echocardiographic characteristics of patients with ischemic and non-ischemic chronic heart failure with reduced ejection fraction

Rate of Recovery of Left Ventricular Ejection Fraction in a Real-World Population of Patients Receiving a Wearable Cardioverter Defibrillator

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