Echovirus 6 associated to aseptic meningitis outbreak, in São Joaquim da Barra, São Paulo, Brazil

Luchs, Adriana; Russo, Denise; Cilli, Audrey; Costa, Fernanda Faria; Morillo, Simone Guadagnucci; Machado, Bráulio Caetano; Pellini, Alessandra Cristina Guedes; Carmona, Rita de Cássia Compagnoli; Timenetsky, María do Carmo Sampaio Tavares

doi:10.1590/s1517-83822008000100007

Cited by 13 publications

(15 citation statements)

References 23 publications

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“…In the specific case of Brazil, E-30 was first described to be involved with aseptic meningitis outbreaks in Southern Brazil between 1998 and 2003 [27]. Subsequently, other outbreaks occurred due to E-30 in different geographic areas of the country, such as the Southeast region (Rio de Janeiro state), and the Northeast region (Pernambuco state) [4,29].…”

Section: Discussionmentioning

confidence: 99%

Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017

Ramalho

Sousa

Burlandy

et al. 2019

Viruses

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Aseptic meningitis is a common viral infection associated with human enteroviruses. The aim of the present study was to identify and characterize the enteroviruses associated with outbreaks and sporadic cases of aseptic meningitis that occurred in different regions of Brazil between 2013 and 2017. Cerebrospinal fluids obtained from patients admitted to public health facilities were analyzed. A total of 303 patients were positive for Human Enteroviruses (EV) by cell culture isolation with a median isolation rate throughout the year of 12%. We were able to identify enterovirus serotypes in 295 clinical specimens. Nineteen different serotypes were identified; the large majority corresponded to HEV-B species. Echovirus 30 (E-30) and Echovirus 6 (E-6) were the most prevalent genotypes (66.8%). Sequence analysis suggested that circulating E-30 was closely related to E-30 from other American countries; while E-6 was derived from Europe. Most of the patients consisted of children ≤ 15 years old. The temporal distribution of all aseptic meningitis and EV-positive cases showed an obvious seasonal pattern during autumn. Our results have provided valuable information about the enteroviral etiology of the aseptic meningitis cases in Brazil pointing to the importance of enterovirus surveillance in neurological diseases.

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Section: Discussionmentioning

confidence: 99%

Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017

Ramalho

Sousa

Burlandy

et al. 2019

Viruses

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“…All three types showed epidemic patterns with outbreaks in 2015 (E6), 2017 (CVB5) and 2019 (CVB5 and E30). Outbreaks of meningitis associated with E30 [ 21 , 24 , 25 , 26 , 27 ] and E6 [ 28 , 29 , 30 , 31 ] were frequently reported in many parts of the world. Similarly, outbreaks of CVB5 meningitis were reported previously [ 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Enteroviral Central Nervous System Infections in Bialystok, Poland: Epidemiology, Viral Types, and Drivers of Seasonal Variation

Toczyłowski

Wieczorek

Bojkiewicz

et al. 2020

Viruses

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Enteroviruses are common causes of infections of the central nervous system (CNS) that in temperate climates tend to peak in the summer. The aim of the study was to describe epidemiology, drivers of seasonality, and types of enteroviruses causing infections of the CNS in children in Northeastern Poland. We prospectively collected data on children hospitalized with infection of the CNS attributed to enteroviruses in Bialystok, Poland, from January 2015 to December 2019. In total, 224 children were included. Nineteen different enterovirus types were identified in isolates collected from 188 children. Coxsackie B5 (32%), echovirus 30 (20%), and echovirus 6 (14%) were the three most common types. Enteroviruses were more prevalent during the summer–fall season. Infections caused by echovirus 30 peaked early in June and coxsackievirus B5 in July, whereas echovirus 6 peaked late in October. Phylogenetic analyses of these three enterovirus types showed multiple lineages co-circulating in this region. Mean air temperatures and precipitation rates were independently associated with monthly number of cases. Considering lack of effective treatment or vaccine, easy transmission of enteroviruses between susceptible individuals, their high mutation rate and prolonged time of viral shedding, continued monitoring and surveillance are imperative to recognize enteroviral infections of the CNS and the changes in circulation of enteroviruses in Poland.

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“…6,7 In Brazil, studies with epidemiological data provided by the surveillance and laboratory investigation of EV infections CNS are limited. [8][9][10][11][12][13][14][15][16][17][18][19] Epidemiological surveillance plays a crucial role in understanding the changing patterns of infection and disease association. 4 In addition, EV type identification is essential to establish which virus is dominant each year or responsible for each outbreak as well for detecting new types or variants in circulation.…”

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confidence: 99%

Distribution of species enterovirus B in patients with central nervous system infections in São Paulo State, Brazil

Carmona

Machado

Sousa

et al. 2020

Journal of Medical Virology

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Enteroviruses (EV) are most common cause of central nervous system (CNS) infection, mainly aseptic meningitis. In Brazil, data available concerning the distribution of EV types are scarce. The aim of this study was to describe of types EV in patients with infection of the CNS in São Paulo State. This retrospective study was conducted in clinical samples collected from patients with infections of the CNS from 2004 to 2014. We investigated the presence of EV by virus isolation in cell culture. The samples that showed cytopathic effect in the cell culture were submitted by indirect immunofluorescence assay, reverse transcription polymerase chain reaction and VP1 partial sequencing to identification of EV isolated. A total of 176 EV isolated in cell culture was detected and typed in 14.5% (n = 176/1215) of clinical samples analyzed; corresponding to 71.0% of AM, and 19.3% of encephalitis and meningoencephalitis. Echoviruses (E) were isolated most frequently, with 155 strains (88.1%), Coxsackievirus B (CV‐B), with 20 cases (11.4%), CV‐A, with 01 case (0.6%). E‐6 was the most commonly identified followed in decreasing order by E‐30; E‐18; CV‐B5; E‐4; E‐11; CV‐B2 and E‐9; E‐7; CV‐A9, CV‐B1, CV‐B3, CV‐B4, E‐13, E‐14, and E‐21. EV detected were classified as belonging to the species enterovirus B. EV were detected in all the period of the year with the highest rate in the spring and summer months. Data obtained in this study contribute to the knowledge about EV circulation implicated in CNS infections over a 11‐year period in São Paulo State, Brazil.

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Echovirus 6 associated to aseptic meningitis outbreak, in São Joaquim da Barra, São Paulo, Brazil

Cited by 13 publications

References 23 publications

Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017

Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017

Pediatric Enteroviral Central Nervous System Infections in Bialystok, Poland: Epidemiology, Viral Types, and Drivers of Seasonal Variation

Distribution of species enterovirus B in patients with central nervous system infections in São Paulo State, Brazil

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