Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

Abstract

Ecklonia cava (EC) has been widely utilized as an ingredient in commercial products such as functional foods and cosmeceuticals. Recently it has been found that Sargassum horneri (SH) has been invading on Jeju Island coast area by its huge blooming. Moreover, both seaweeds are considering as important ingredients in traditional medicine specifically in East-Asian countries (China, Japan, and Korea). In the present study, we attempted to compare anti-inflammatory properties of 70% ethanolic extracts of EC (ECE), SH (SHE), and their different combinations on lipopolysaccharide (LPS)-activated RAW 264.7 cells. Results indicated that 8 : 2 combinations of ECE : SHE significantly inhibited LPS-activated inflammatory responses (cytokines, protein, and gene expression) in RAW 264.7 macrophage cells compared to the respective extracts and other combinations. The synergistic effect of ECE and SHE was found to be prominent than the effects of ECE or SHE alone. These observations provide useful information for the industrial formulation of functional materials (functional foods and cosmeceuticals) using these two particular seaweeds in Jeju Island of South Korea.

Drying seaweeds using hybrid hot water Goodle dryer (HHGD): comparison with freeze-dryer in chemical composition and antioxidant activity

“…The general composition of seaweeds dried from HHGDM and FDM were analyzed according to the AOAC standard 2005 standards (AOAC Internationa l, 2005). The ash content of seaweed samples from the two different drying methods were measured by drying in a furnace at 550℃ for 6 h (Sanjeewa et al, 2019). Kjeldahl digestion method was used to determine the protein content of seaweed samples from HHGDM and FDM.…”

The Anti-Oxidative and Anti-Neuroinflammatory Effects of Sargassum horneri by Heme Oxygenase-1 Induction in BV2 and HT22 Cells

“…However, the accumulation and overproduction of NO and PGE 2 are indicative of chronic inflammation or cancer. It has been reported that different types of S. horneri ethanol extracts inhibit the overproduction of NO and PGE 2 in LPS-stimulated macrophage RAW264.7 cells [34,[42][43][44][45][46]. Moreover, treatment with ethanol extract of S. horneri was shown to decrease NO and PGE 2 levels in fine dust-induced RAW264.7 cells [47].…”

Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

“…Marine algae are rich in functional ingredients such as polysaccharides, polyphenols, phytosterols, and carotenoids (Lee et al 2013, 2016, Shanura Fernando et al 2017, Asanka Sanjeewa et al 2019, Ding et al 2019, Dai et al 2020. Pyropia species, belonged to Bangiaceae family which are the most important perennial edible marine red algae, are cultivated and consumed in East and Southeast Asian countries such as Korea, Japan, and China.…”