Eclalbatin, a Triterpene Saponin from<i>Eclipta Alba</i>

Upadhyay, Richa; Pandey, M. B.; Jha, R. N.; Pandey, Vaibhav

doi:10.1080/10286020108041393

Cited by 41 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The shoot extract shows antimicrobial activity against Staphylococcus aureus and Escherichia coli. From the whole plant of E. alba, a new triterpene saponin, namely, eclalbatin, together with alpha-amyrin, ursolic acid, and oleanolic acid, have been isolated (Upadhyay et al 2001). In Ayurveda, a large number of indigenous drugs have been mentioned possessing analgesic properties.…”

Section: Introductionmentioning

confidence: 99%

Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)

Govindarajan

Sivakumar

2011

Parasitol Res

View full text Add to dashboard Cite

Several diseases are associated to the mosquito-human interaction. Mosquitoes are the carriers of severe and well-known illnesses such as malaria, arboviral encephalitis, dengue fever, chikunguniya fever, West Nile virus, and yellow fever. These diseases produce significant morbidity and mortality in humans and livestock around the world. The adulticidal and repellent activities of crude hexane, ethyl acetate, benzene, chloroform, and methanol extracts of leaf of Eclipta alba and Andrographis paniculata were assayed for their toxicity against two important vector mosquitoes, viz., Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). The adult mortality was observed after 24 h of exposure. All extracts showed moderate adulticide effects; however, the highest adult mortality was found in methanol extract of A. paniculata against the adults of C. quinquefasciatus and A. aegypti with the LC(50) and LC(90) values were 149.81, 172.37 ppm and 288.12, 321.01 ppm, respectively. The results of the repellent activity of hexane, ethyl acetate, benzene, chloroform, and methanol extract of E. alba and A. paniculata plants at three different concentrations of 1.0, 2.5, and 5.0 mg/cm(2) were applied on skin of forearm in man and exposed against adult female mosquitoes. In this observation, these two plant crude extracts gave protection against mosquito bites without any allergic reaction to the test person, and also, the repellent activity is dependent on the strength of the plant extracts. These results suggest that the leaf solvent plant extracts have the potential to be used as an ideal ecofriendly approach for the control of mosquitoes. This is the first report on the mosquito adulticidal and repellent activities of the reported E. alba and A. paniculata plants.

show abstract

Section: Introductionmentioning

confidence: 99%

Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)

Govindarajan

Sivakumar

2011

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The 3-O-fatty acid ester derivatives C12-C18 of ursolic acid (79)(80)(81)(82)(83)(84) were screened for their antifeedant activity against the agricultural pest tobacco caterpillar larvae (Spodoptera litura F) in a no-choice laboratory study. The Urs-12-ene-28-carboxy-3β-octadecanoate and olean-12-ene-28-carboxy-3β-hexadecanoate were found to exhibit exceptionally potent antifeedant activities at 50 µg/cm 2 concentration (Scheme 13).…”

Section: 9antifeedant Activity Of Some Triterpene Acids and Their mentioning

confidence: 99%

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Sultana

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

102

View full text Add to dashboard Cite

Medicinal plants are becoming an important research area for novel and bioactive molecules for drug discovery. Novel therapeutic strategies and agents are urgently needed to treat different incurable diseases. Many plant derived active compounds are in human clinical trials. Currently ursolic acid is in human clinical trial for treating cancer, tumor, and skin wrinkles. This review includes the clinical use of ursolic acid in various diseases including anticancer, antitumor, and antiwrinkle chemotherapies, and the isolation and purification of this tritepernoid from various plants to update current knowledge on the rapid analysis of ursolic acid by using analytical methods. In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, antiinflammatory, anti-HIV, acetyl cholinesterase, α-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives. This review article contains fourteen medicinally important ursolic acid derivatives and 351 references.

show abstract

“…3 This plant is well documented and several in vitro and in vivo studies describe its anti-ageing agent and anti-hepatotoxic properties. 4 Coumestans like wedelolactone, desmethyl wedelolactone, 5 furano-coumarins, ecalbatin, 6 eleanane & taraxastane glycosides, 7,8 are the consisting main active principles in E. alba. The safety, efficacy and quality of some of bioactive principles have not been scientifically validated and antibacterial activity was also not studied for isolated phytochemicals present in it.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antibacterial Activity of Alkaloids Isolated from Leaves of Eclipta alba Against Human Pathogenic Bacteria

Gurrapu¹,

Mamidala²

2017

Phcog J

View full text Add to dashboard Cite

The susceptibility of five human pathogenic bacterial species to an alkaloids isolated from the leaves of this plant was screened using the agar well diffusion and broth micro-dilution assay. The purity of isolated alkaloids was checked by TLC and qualitative phytochemical analysis and total alkaloids were quantified. In the present study, the inhibitory action of the alkaloid was found to increase with an increase in concentration against all bacterial strains. The maximum zone of inhibition was observed at the concentration of 500 µg/ml against all the bacteria. In this study, the S. aureus and E. coli are the more susceptible than the other selected human pathogenic bacteria. Based on the observations, E. alba appears to be a valuable source for antimicrobial properties and helps to produce antimicrobial agents to treat human pathogenic infections. Context: Different parts of Eclipta alba crude extracts are used traditionally for the treatment of several diseases of liver, skin and stomach. Aims: To study the in vitro antimicrobial activity of alkaloids isolated from E. alba against human pathogenic bacteria. Settings and Design: The susceptibility of five human pathogenic bacterial species to an alkaloids isolated from the leaves of this plant was screened using the agar well diffusion and broth micro-dilution assay. Methods and Material: The purity of isolated alkaloids was checked by TLC and qualitative phytochemical analysis and total alkaloids were quantified. Agar-well diffusion and Broth micro-dilution methods were selected to assess the antimicrobial activity. Statistical analysis used: One-way analysis of variance (ANOVA) was used to determine statistical significance. Results: In the present study, the inhibitory action of the alkaloid was found to increase with an increase in concentration against all bacterial strains. The maximum zone of inhibition was observed at the concentration of 500 µg/ml against all the bacteria. In this study, the S. aureus and E. coli are the more susceptible than the other selected human pathogenic bacteria. Conclusion: Based on the observations, E. alba appears to be a valuable source for antimicrobial properties and helps to produce antimicrobial agents to treat human pathogenic infections.

show abstract

Eclalbatin, a Triterpene Saponin fromEclipta Alba

Cited by 41 publications

References 6 publications

Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)

Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

In vitro Antibacterial Activity of Alkaloids Isolated from Leaves of Eclipta alba Against Human Pathogenic Bacteria

Contact Info

Product

Resources

About