The recurrent nova U Scorpii most recently erupted in 2010. Our collaboration observed the eruption in bands ranging from the Swift XRT and UVOT w2 (193 nm) to K-band (2200 nm), with a few serendipitous observations stretching down to WISE W2 (4600 nm). Considering the time and wavelength coverage, this is the most comprehensively observed nova eruption to date. We present here the resulting multi-wavelength light curve covering the two months of the eruption as well as a few months into quiescence. For the first time, a U Sco eruption has been followed all the way back to quiescence, leading to the discovery of new features in the light curve, including a second, as-yet-unexplained, plateau in the optical and near-infrared. Using this light curve we show that U Sco nearly fits the broken power law decline predicted by Hachisu & Kato, with decline indices of −1.71 ± 0.02 and −3.36 ± 0.14. With our unprecedented multi-wavelength coverage, we construct daily spectral energy distributions and then calculate the total radiated energy of the eruption, E We compare this to the total amount of mass accreted by U Sco before the eruption, to determine whether the white dwarf undergoes a net mass loss or gain, but find that the values for the amount of mass accreted are not precise enough to make a useful comparison. et al. 2010a, 2010bSimonson & MacRobert 2010). The discovery triggered a worldwide invocation of both pre-planned (target of opportunity) and serendipitous observing programs. This was the tenth observed eruption of U Sco (Schaefer 2010), and became by far the best observed nova eruption to date. The eruption began on JD 2455224.32 ± 0.12, peaked on JD 2455224.69 ± 0.07 (T 0 ) at V = 7.5 mag, and returned to quiescence 67 days later (Schaefer et al. 2010b).We present multi-wavelength photometry of the complete eruption obtained by our extensive collaboration of both professional and amateur astronomers. U Sco was observed in all wavelengths from radio to gamma-rays during the 2010 eruption, with detections from IR to soft X-ray. The fast time variations of the light curve are discussed in detail in Schaefer et al. (2011); here we focus on the overall shape and spectral energy distribution (SED). We construct daily SEDs and use them to get a new estimate of the total amount of mass ejected during the eruption, m ej , following the method described in Shara et al. (2010). It is critical to get a good measurement of m ej and compare it to estimates of the total amount of mass accreted during the time interval preceding the eruption to ascertain whether the white dwarf (WD) in the system is gaining or losing mass over the course of the eruption cycle. If the WD, which is already near the Chandrasekhar limit (Hachisu et al. 2000;Thoroughgood et al. 2001), is in fact gaining mass and is composed primarily of carbon and oxygen, it must eventually become a Type Ia supernova (SN Ia). Determining whether RNe can become SNe Ia takes us one step closer to solving the long-standing SN Ia progenitor problem and im...