Eco-friendly approach for nanoparticles synthesis and mechanism behind antibacterial activity of silver and anticancer activity of gold nanoparticles

Patil, Maheshkumar Prakash; Kim, Gun‐Do

doi:10.1007/s00253-016-8012-8

Cited by 308 publications

(157 citation statements)

References 111 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Nanotechnology has become one of the most used technologies world-wide, and has conquered a wide variety of products such as medicines, pharmaceuticals, agricultural products, cosmetics, cleaning materials, electronic components, food additives, sports equipment and surface coatings (Hu et al 2011;Patil and Kim 2017). However, little is known about the impact of nanoparticles in the environment and human health.…”

Section: Discussionmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

View full text Add to dashboard Cite

In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro-and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish. Special focus is made on morphological abnormalities, altered development and abnormal behavior. The last part of the review debates changes that should be made in future directions in order to improve the use of the zebrafish model to assess nanotoxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

View full text Add to dashboard Cite

show abstract

“…31,32 Ag NPs have antimicrobial activity against a wide spectrum of microbes (probably due to their multiple mechanisms of antimicrobial action), including activity against drug-resistant bacteria, fungi (such as Candida albicans) and viruses. [33][34][35][36] Ag NPs are emerging as efficient antimicrobial agents because of their different mechanisms of sterilization, 32,37,38 although no final conclusion about mechanisms has been made. Recent studies suggest that the primary mechanism of the antibacterial action of Ag NPs is to release silver ion (Ag + ).…”

Section: Sliver Nanoparticles (Ag Nps)mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

317

230

View full text Add to dashboard Cite

The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

show abstract

“…Table 1 presents some relevant studies regarding the antimicrobial potential of phytosynthesized silver nanoparticles. Antimicrobial mechanism of nanoparticles (adapted from [9][10][11][12]).…”

Section: Antimicrobial Applicationsmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

View full text Add to dashboard Cite

Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

show abstract

Eco-friendly approach for nanoparticles synthesis and mechanism behind antibacterial activity of silver and anticancer activity of gold nanoparticles

Cited by 308 publications

References 111 publications

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Antimicrobial hydrogels: promising materials for medical application

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Contact Info

Product

Resources

About