Eco-Friendly Highly Sensitive Transducers Based on a New KNN–NTK–FM Lead-Free Piezoelectric Ceramic for High-Frequency Biomedical Ultrasonic Imaging Applications

Chen, Ruimin; Jiang, Laiming; Zhang, Tianfu; Matsuoka, Takahiro; Yamazaki, Masato; Qian, Xuejun; Lu, Guoxing; Safari, A.; Zhu, Jianguo; Shung, K. Kirk; Ma, Teng; Zhou, Qifa

doi:10.1109/tbme.2018.2876063

Cited by 54 publications

(27 citation statements)

References 49 publications

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“…The pulse-echo response of the transducer was measured and analyzed by the method described in [34]. The transducer was mounted on a holder and immersed in a tank filled with deionized water.…”

Section: A Transducer Performance Evaluationmentioning

confidence: 99%

Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application

Chen

Shi

et al. 2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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We report the development of an optically transparent high-frequency ultrasonic transducer using lithium niobate single-crystal and indium-tin-oxide electrodes with up to 90 % optical transmission in the visible to near infrared spectrum. The center frequency of the transducer was at 36.9 MHz with 33.9 %, at −6 dB fractional bandwidth. Photoacoustic imaging capability of the fabricated transducer was also demonstrated by successfully imaging a resolution target and mouse ear vasculatures in vivo, which were irradiated by a 532 nm pulse laser transmitted through the transducer.

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Section: A Transducer Performance Evaluationmentioning

confidence: 99%

Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application

Chen

Shi

et al. 2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…The two-way insertion loss (IL), another important parameter to characterize transducer performance, is defined as the ratio of the transducer output voltage ( V 0 ) to the driving voltage ( V d ) delivered to the transducer, used as a measure of the sensitivity of the transducer Figure e shows the IL on the basis of frequency (10–35 MHz) of the lead-free composite transducer, which is evaluated via wherein the attenuation of the water path (α water = 2.2 × 10 –4 dB (mm MHz 2 ) −1 ), the diffraction of the quartz target (1.9 dB) are included as compensation for the final IL.…”

Section: Resultsmentioning

confidence: 99%

Potassium Sodium Niobate-Based Lead-Free High-Frequency Ultrasonic Transducers for Multifunctional Acoustic Tweezers

Jiang

Chen

Zeng

et al. 2022

ACS Appl. Mater. Interfaces

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Ultrasonic transducers may need to operate in direct contact with the human body, especially with the skin or closer to blood vessels. Eco-friendly lead-free materials and devices are therefore being vigorously developed for biosafety considerations. This work presents high-performance potassium sodium niobate [(K,Na)NbO3, KNN]-based lead-free ceramics with composition-driven multiphase coexistence and their application on high-frequency ultrasonic transducers for multifunctional acoustic tweezers. A high piezoelectric constant d 33 value of 332 pC/N, a good Curie temperature T C value of 348 °C, and improved in situ temperature stability were obtained in the piezoceramics via the construction multiple phases near room temperature and domain engineering. One to three piezocomposites were further fabricated based on the synthesized ceramics for higher electromechanical coupling properties. Lead-free high-frequency transducers as multifunctional acoustic tweezers for precise and selective manipulation of microparticles were designed and manufactured with a high center frequency of 23.4 MHz and a broad −6 dB bandwidth of 75.4%. Additionally, a stable transducer performance was obtained over a test temperature range of 23–60 °C, indicating good thermal stability in environments with fluctuating temperatures. Research on lead-free high-frequency transducers for ultrasound imaging and precise and selective manipulation of microparticles demonstrates their broad potential in fields such as medical therapy and diagnosis.

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“…Visual targeting makes use of ultrasonic imaging, which is a real-time imaging technology that can visualize the structures of organs. 44–46 MBs in particular can be used as contrast agents to enhance the utility of ultrasound images. 45 By choosing the appropriate ultrasound frequency and other ultrasound parameters, we predict that it will be possible to realize tumor imaging and tracking of the drug release process of GA/PLGA-CMBs under the action of FUS.…”

Section: Discussionmentioning

confidence: 99%

A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma

Dong¹,

Li²,

Wei³

et al. 2022

IJN

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Background The blood–brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new type of drug delivery system with particular utility in glioma. Purpose We have developed a new type of drug-loaded microbubble complex based on poly(lactic-co-glycolic acid) (PLGA) that targets gambogic acid (GA) to the area of brain tumors through UTMD. Methods GA/PLGA nanoparticles were prepared by the double emulsification method, and cationic microbubbles (CMBs) were prepared by a thin film hydration method. The GA/PLGA-CMB microbubble complex was assembled through electrostatic attractions and was characterized chemically. The anti-glioblastoma effect of GA/PLGA-CMB combined with focused ultrasound (FUS) was evaluated by biochemical and imaging assays in cultured cells and model mice. Results GA/PLGA-CMB combined with FUS demonstrated a significant inhibitory effect on glioblastoma cell lines U87 and U251 as compared with controls (P<0.05). Tumor access and imaging analyses demonstrated that administration of GA/PLGA-CMBs combined with FUS can open the BBB and target the treatment of glioblastoma in a mouse model, as compared with control groups (P<0.05). Conclusion The combination of PLGA-CMB with FUS provides an effective and biocompatible drug delivery system, and its application to the delivery of GA in a mouse glioblastoma model was successful.

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Eco-Friendly Highly Sensitive Transducers Based on a New KNN–NTK–FM Lead-Free Piezoelectric Ceramic for High-Frequency Biomedical Ultrasonic Imaging Applications

Cited by 54 publications

References 49 publications

Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application

Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application

Potassium Sodium Niobate-Based Lead-Free High-Frequency Ultrasonic Transducers for Multifunctional Acoustic Tweezers

A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma

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