Eco-friendly reductive acetamidation of arylnitro compounds by thioacetate anion through in situ catalytic regeneration: application in the synthesis of Acetaminophen™

Potassium carbonate as a green catalyst for Markovnikov addition of azoles to vinyl acetate in PEG

“…Using potassium carbonate as green catalyst, our group has successfully carried out the synthesis of substituted 2-amino-4H-chromenes (23), thieno-pyrimidines (24), organomercurials (25), fused pyrimido derivatives (26), and thiohydantoins (27). The various articles reported reactions of K 2 CO 3 not only showing its essentiality for a particular reaction but also depicting its other characteristics like solubility in water, mild character (19,28), easy availability, eco-friendly (29,30), and nontoxic nature (18,23). Thus potassium carbonate provides a mild basic medium for organic reactions to occur and get removed by easy separation by water.…”

The hydrogen bond donor and acceptor ability of thioformic acid

“…The H-bonding of FA with water helps in understanding the structural and dynamic conformational behavior of complex molecules such as folding of proteins and understanding the catalytic activities in biological systems. The thio-carboxylic acids are also receiving attention of researchers due to their bio-chemical and pharmaceutical applications [13][14][15][16][17]. Thioacids are being used in synthesizing proteins as well as in polymer assembly [18,19].…”

Cooperation of a Reductant and an Oxidant in One Pot To Synthesize Amides from Nitroarenes and Aldehydes

“…A novel one-step reductive acetamidation of nitroarenes mediated by thioacetate anion in thioacetic acid via in situ catalytic regeneration was developed and applied to an efficient synthesis of Acetaminophen. 13 Liu and coworkers 14 constructed amides from nitroarenes by one-pot tandem reduction-cyclization with sodium dithionite. Jain et al 15 have reported manganese dioxide catalyzed amide bond formation directly from aldehydes and nitroarenes in chloroform (60 °C, 12 h, under N 2 ), which was the first report of synthesis of amides directly from nitroarenes and aldehydes in one pot.…”