Eco-Friendly Synthesis of Bioactive Heterocycles

Gharib, Ali

doi:10.1007/978-81-322-1850-0_3

Cited by 2 publications

(1 citation statement)

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“…2 To this end, groups in both academia and the pharmaceutical industry are constantly searching to develop new synthetic methods that give improved access to heterocycles in terms of yield, diversity, 3 synthetic utility and that possess 'greener' properties. 4 As part of our groups' contribution to the field, we have set out to discover and develop new methods for the synthesis of complex heterocycles, primarily through the application of flow chemistry techniques in the field of photochemistry. 5 Flow chemistry has had a transformative effect on the field of synthetic chemistry 6 and has become integral to modernday pharmaceutical science.…”

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confidence: 99%

Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method

Fang

Tranmer

2016

Org. Biomol. Chem.

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A single-step continuous flow method has been developed that gives expedited access to complex heterocycles via an intramolecular photochemical cyclization. Herein we report the first examples of the photochemically-induced generation of thieno[3,2-c]quinolin-4(5H)-ones, 16 examples, and benzo[h]-1,6-naphthyridin-5(6H)-ones, 6 examples. Overall, the continuous flow method provides access to complex heterocycles in two steps from commercially available starting materials in good yields and with greater atom efficiency than traditional batch reactions.

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confidence: 99%