Eco‐friendly, ultrasound‐assisted, and facile synthesis of one‐pot multicomponent reaction of acridine‐1,8(2H,5H)‐diones in an aqueous solvent

Abstract

A one‐pot, multistep synthesis of acridine‐1,8(2H,5H)‐diones (4a–m) was achieved by three‐component reaction of dimedone (1) with an aromatic aldehyde (2a–m) and an ammonium acetate (3) using water as a green solvent without any catalyst and a simple, easily handled, and ultrasonic technique as well as conventional method.

Room temperature ionic liquid promoted improved and rapid synthesis of highly functionalized imidazole and evaluation of their inhibitory activity against human cancer cells

“…b Reaction conditions : (B) Benzoins (1 mmol), aldehydes (1 mmol), anilines (1 mmol), and NH 4 OAc (2.10 mmol) in medium (5 ml), stirred at Room Temperature. All products were characterized by a comparison of their spectroscopic data (FT‐IR, 1 H NMR) with those reported in the literature 13–59 . b Isolated yields c : no condensation.…”

“…Likewise, imidazole, most crucial precursor in chemistry and their salts are broadly applied in chemical synthesis parallel with the use of DBU or Imidazole‐based ILs in organic reactions, parallel with the help of DBU or Imidazole‐based ILs in organic transformations. They also have been used as a reaction medium for multicomponent reactions (MCRs) 47–50 . MCRs are a desirable synthetic approach because diversity can be reached simply by changing their active components, and involved products are formed in a single step 51 …”

Ultrases Destekli 9-(Substitue heteroaril) akridindion Türevlerinin Tek Basamakta Sentezi

“…3. The hexahydroacridine 1,8-(2H,5H)-dione derivatives (3a-f) are probably formed by the commonly accepted route [26].…”

“…Hence, the use of sonochemical methods in organic synthesis has been evaluated as substantial steps to improve and accelerate the synthetically precious reactions. Ultrasound-assisted reactions can be distinguished from the conventional synthetic methods by their potential to serve as an alternative pathway for various chemical reactions and also synthesizing the complex molecules with short reaction times and mild conditions [26][27][28].…”

Investigation of Acridinedione Derivative Synthesis with Versatile Morphologies of Bi2O3 Nanoparticles

“…3,3,6,6-Tetramethyl-9-(2,4-dimethoxyphenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione (3a): mp: 265-267 °C , IR (KBr: ν/cm −1 ): 3190, 3065, 2954, 1636, 1602, 1480, 1395, 1363, 1292, 1261, 1217, 1144, 1124, 1041, 928, 825 [9]. 9-(4-hydroxyphenol)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione (4a): mp: 272-274 °C , IR (KBr: ν/cm −1 ): 3273, 2963, 1645, 1394 [10].…”