“…The extent and quality of their interactions with both their cultures of origin and the U.S. culture, and the cultural identities they adopt personally, may influence their decisions about engaging in health-promoting and health-compromising behaviors (Guzman, Santiago-Rivera, & Hasse, 2005; Marcell, 1994; Umaña-Taylor & Fine, 2001). Indeed, research reveals significant variation in adolescent substance use across national subgroups such as Mexican Americans, Puerto Ricans, Cuban Americans, and Salvadoran Americans (Delva et al, 2005; Prado et al, 2009; Vaeth, Caetano, Ramisetty-Mikler, & Rodriguez, 2009) and among first-, second-, and third-generation Hispanic Americans (Eitle, Wahl, & Aranda, 2009), as well as associations between substance use and acculturation (Bethel & Schenker, 2005; Castro, Stein, & Bentler, 2009; De La Rosa, 2002; Eitle et al, 2009; Marsiglia, Kulis, Hussaini, Nieri, & Becerra, 2010; Unger et al, 2000; Zamboanga, Schwartz, Jarvis, & Van Tyne, 2009). …”