Ecoepidemiology of Alphaviruses and Flaviviruses

Guzmán, Camilo; Calderón, Alfonso; Máttar, Salim; Tadeu-Figuereido, Luiz; Salazar‐Bravo, Jorge; Alvis-Guzmán, Nelson; Martinez, Elias Zakzuk; González, Marco

doi:10.1016/b978-0-12-819400-3.00006-5

Cited by 21 publications

(8 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of global warming, the destruction of natural habitats and increases in international travel and trade have all served to increase both the spread of insect vector-borne parasitic diseases and the emergence of new microbial threats of pandemic proportions [ 19 , 20 ]. For example, Aedes albopictus , the highly invasive Asian tiger mosquito, was probably introduced into Europe in 1990 via Italy in imported vehicle tyres.…”

Section: Introductionmentioning

confidence: 99%

Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

et al. 2022

View full text Add to dashboard Cite

This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered. Graphical Abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…was the main contributing gene and multiple pathways were enriched for viral responses (Supplementary Table 5). From taxonomic profiling, we could attribute Kitrinoviricota viral signals to the family Flaviviridae, which is a family of primarily found in mosquitos and ticks, and is responsible for multiple human illnesses including Zika, Dengue, and Yellow Fever [76,77], alhough we were unable to refine this assignment further.…”

Section: Discussionmentioning

confidence: 98%

“…Responses to viral infections were also apparent in IC4, where RSAD2 , a well-characterised gene involved in the antiviral response [62], was the main contributing gene and multiple pathways were enriched for viral responses (Supplementary Table 5). From taxonomic profiling, we could attribute Kitrinoviricota viral signals to the family Flaviviridae, which is a family of primarily found in mosquitos and ticks, and is responsible for multiple human illnesses including Zika, Dengue, and Yellow Fever [76, 77], alhough we were unable to refine this assignment further. For Apicomplexa, we could attribute 99.9% of reads to the family Plasmodiidae, of which Plasmodium falciparum and Plasmodium vivax are endemic throughout Indonesia [78].…”

Section: Discussionmentioning

confidence: 99%

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

Bobowik

Darusallam

Kusuma

et al. 2022

Preprint

View full text Add to dashboard Cite

Pathogens found within local environments are a major cause of morbidity and mortality. This is particularly true in Indonesia, where infectious diseases such as malaria or dengue are a significant part of the disease burden within the country. One way to strengthen the control of infectious diseases is through better surveillance, however unequal investment in medical funding throughout Indonesia, particularly in rural areas, has resulted in under-reporting of cases. Here, we use transcriptome data from 117 healthy individuals living on the islands of Mentawai, Sumba, and the Indonesian side of New Guinea Island to explore which pathogens are present within whole blood. We are able to detect a broad range of taxa within RNA-sequencing data generated from whole blood, including bacteria, viruses, archaea, and eukaryotes. Using independent component analysis, we find that two of these pathogens—Flaviviridae and Plasmodium—have the most noticeable effects on expression profiles. We also identify specific genes linked with Plasmodium and Flavivirus abundance and find that both of these infections are most pronounced in the easternmost island within our Indonesian dataset. This study provides a framework for novel applications of RNA-seq as surveillance and a better understanding of environmental contributors affecting gene expression within Indonesia.

show abstract

“…The former is the arthropod's ability to transmit a specific infectious agent. The latter refers to a mosquito's future infectious bites, which are related to survival and feeding probability and vector competence, among others (Rückert and Ebel 2018;Guzmán et al 2020). Host-related factors are associated with human immunity (Eder et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Identification, ecological indices and management of mosquitoes (Diptera: Culicidae) influencing environmental education processes in Colombian high schools

Bedoya-Rodríguez

Fletcher

Vera-Lizcano

2021

Int J Trop Insect Sci

View full text Add to dashboard Cite

Vector-borne diseases annually cause more than 700,000 deaths worldwide. In Colombia, infectious diseases are prevalent, being the Municipality of Santander de Quilichao (Cauca district) one of the most affected areas. This study aimed (a) to determine the abundance of species of mosquitoes with the potential capacity to transmit infectious diseases, in a school located in the Cauca district and (b) to teach students self-care and care for the environment to protect themselves from vector-borne diseases. During 2019 and 2020, in a dry and rainy season, manual collection of mosquitoes in four sites of the institution was conducted. Ecological statistical analyses were carried out. Mosquito species were grouped by similarity (abundance) using a dendrogram by area and a species rarefaction curve. A sociodemographic survey on knowledge, attitudes, and practices related to vector-borne diseases was carried out. An educational booklet was developed, and its impact was validated through the nonparametric Wilcoxon test. In total, 108 specimens were captured from four species: Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Psorophora ferox. The greater presence of mosquitos was during the rainy season, being Aedes aegypti the most abundant species. According to Likert's analysis, 59.6% of the students had a very favorable attitude toward the subject; the educational campaign significantly improved knowledge, attitudes, and practices of the students. Finally, the study presents entomological data of interest in public health. That makes it possible to establish prevention and control measures for vector-borne diseases in high schools, through environmental education.

show abstract

Ecoepidemiology of Alphaviruses and Flaviviruses

Cited by 21 publications

References 89 publications

Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

Identification, ecological indices and management of mosquitoes (Diptera: Culicidae) influencing environmental education processes in Colombian high schools

Contact Info

Product

Resources

About