Objective:
This longitudinal study assessed whether changes in socioeconomic status (SES) from infancy to adolescence were associated with plasma lipoprotein concentrations in adolescence, of which low HDL-c and high LDL-c, triglycerides, and total cholesterol concentrations are associated with higher cardiovascular risk.
Design:
SES, assessed using the modified Graffar Index, was calculated at 1, 5, 10, and 16 years. Principal components factor analysis with varimax rotation extracted two orthogonal SES factors, termed environmental capital and social capital. Generalized linear models were used to analyze associations between environmental and social capital at 1 and 16 years and outcomes (HDL-c, LDL-c, triglycerides, total cholesterol) at 16 years, as well as changes in environmental and social capital from years 1-5, 5-10, 10-16, and 1-16 years, and outcomes at 16 years.
Setting:
Santiago, Chile.
Subjects:
We evaluated 665 participants from the Santiago Longitudinal Study enrolled at infancy in iron-deficiency anemia studies and examined every 5 years to age 16.
Results:
Social capital in infancy was associated with higher HDL-c in adolescence. Environmental capital in adolescence was associated with higher LDL-c and total cholesterol during adolescence. Changing environmental capital from 1-16 years was associated with higher LDL-c. Changing environmental capital from 1-5 and 1-16 years was associated with higher total cholesterol.
Conclusions:
Improvements in environmental capital throughout childhood were associated with less healthy LDL-c and total cholesterol concentrations in adolescence. We found no evidence of associations between changing environmental capital and HDL-c or triglycerides, or changing social capital and HDL-c, LDL-c, triglycerides, or total cholesterol.