Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics

Abdelwahab, Nada S.; Morsi, Amani; Ahmed, Yasmine M.; Hassan, Hossam M.; AboulMagd, Asmaa M.

doi:10.1039/d0ra08836f

Cited by 10 publications

(3 citation statements)

References 43 publications

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“…A rat animal model was recently used to compare the pharmacokinetics of metformin, a first-line anti-diabetic drug, with and without the concomitant administration of fenugreek extract. According to the findings, taking fenugreek and metformin at the same time boosted the metformin bioavailability and reduced the drug distribution volume by 70% [ 23 ]. The researcher concluded that this combination could be a useful way to control the blood sugar levels in diabetic patients.…”

Section: Pharmacological Uses Of T Foenum-graecummentioning

confidence: 99%

Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities

Visuvanathan

Than

Stanslas

et al. 2022

Plants

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Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant that has been used as a food condiment as well as for its multiple therapeutic characteristics since ancient times. Fenugreek plant grows up to 60 cm in height, and its seeds are golden-yellow rhomboidal-shaped. Though fenugreek is more commonly known for its seeds, the leaves and stem have also been reported to have medicinal uses. These properties exhibited are due to the content of the secondary metabolites, also known as phytochemicals, in the fenugreek plant. Such metabolites are alkaloids, saponins, tannins, phenols, and many others. Fenugreek has been used traditionally for numerous indications, such as aid in labour, lactation stimulant, and laxatives. In modern research, there have been several animal and clinical studies that have shown therapeutic effects of fenugreek when taken orally. Fenugreek is a suitable plant candidate with a high prospect of being used as a credible medicinal plant to derive new drugs. This review aims to summarize the physical and chemical properties of fenugreek and its bioactive compounds that have been isolated for medicinal purposes and discusses the traditional and pharmacological uses of fenugreek.

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Section: Pharmacological Uses Of T Foenum-graecummentioning

confidence: 99%

Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities

Visuvanathan

Than

Stanslas

et al. 2022

Plants

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“…Various criteria are currently utilized to evaluate the environmental impact of various analytical methodologies, however, multi-criteria decision analysis (MCDA) allows for a rating of available analytical methods based on many evaluation criteria at the same time. The Analytical GREEnness (AGREE) [43] calculator is a comprehensive, adaptable, and clear approach to assessing the greenness of analytical procedures. It is based on 12 green chemistry principles.…”

Section: Introductionmentioning

confidence: 99%

Development and Greenness Assessment of HPLC Method for Studying the Pharmacokinetics of Co-Administered Metformin and Papaya Extract

et al. 2022

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Foods with medical value have been proven to be beneficial, and they are extensively employed since they integrate two essential elements: food and medication. Accordingly, diabetic patients can benefit from papaya because the fruit is low in sugar and high in antioxidants. An RP-HPLC method was designed for studying the pharmacokinetics of metformin (MET) when concurrently administered with papaya extract. A mobile phase of 0.5 mM of KH2PO4 solution and methanol (65:35, v/v), pH = 5 ± 0.2 using aqueous phosphoric acid and NaOH, and guaifenesin (GUF) were used as an internal standard. To perform non-compartmental pharmacokinetic analysis, the Pharmacokinetic program (PK Solver) was used. The method’s greenness was analyzed using two tools: the Analytical GREEnness calculator and the RGB additive color model. Taking papaya with MET improved the rate of absorption substantially (time for reaching maximum concentration (Tmax) significantly decreased by 75% while maximum plasma concentration (Cmax) increased by 7.33%). The extent of absorption reduced by 22.90%. Furthermore, the amount of medication distributed increased (30.83 L for MET concurrently used with papaya extract versus 24.25 L for MET used alone) and the clearance rate rose by roughly 13.50%. The results of the greenness assessment indicated that the method is environmentally friendly. Taking papaya with MET changed the pharmacokinetics of the drug dramatically. Hence, this combination will be particularly effective in maintaining quick blood glucose control.

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“…Other recent drugs include di-peptidyl peptidase 4 inhibitors and sodium glucose co transporter 2 inhibitors (SGLT2) which have been approved after several characterization methods [2]. Previously, large number of drugs with different backgrounds such as anti-cancer and anti-neurological has been employed bioanalytical method for the successful estimation and quantification from different naturally occurring compounds [3,4]. Analytical chemistry and pharmaceutical analysis is the art of determining the composition of the target drug.…”

Section: Introductionmentioning

confidence: 99%

insight of development and validation of bio-analytical method in the reference of anti-diabetic drugs by using LC-MS/MS

Swain¹,

Kar²,

Kumari³

et al. 2022

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Diabetes mellitus, which has high rates of disability and mortality, is one of the main causes of public health concerns worldwide. It currently poses serious medical and societal issues. Different bio-analytical techniques have been developed to identify the pharmaceutical formulation of the anti-diabetic drug. Due to the continual requirement to achieve improved sensitivity, accuracy, and speed of analysis in complex biological samples, the development of bio-analytical sample preparation techniques has grown more difficult over time (e.g., blood, serum, plasma, saliva, feces, and urine). This is a mini review, and its goal is to analyze how LC-MS/MS has been used to for the pharmaceutical formulation of the anti-diabetic drugs. The method was validated for linearity, accuracy, precision, specificity, selectivity, and stability.

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Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics

Abstract: The combination of fenugreek extract and metformin can be considered as an auspicious treatment for satisfactory diabetes control and minimizing the expected long-term complications of metformin.

Cited by 10 publications

References 43 publications

Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities

Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities

Development and Greenness Assessment of HPLC Method for Studying the Pharmacokinetics of Co-Administered Metformin and Papaya Extract

insight of development and validation of bio-analytical method in the reference of anti-diabetic drugs by using LC-MS/MS

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