Ecological impact of MCB3837 on the normal human microbiota

Rashid, Mamun Ur; Dalhoff, Axel; Bäckström, Tobias; Björkhem‐Bergman, Linda; Panagiotidis, Georgios; Weintraub, Andrej; Nord, Carl Erik

doi:10.1016/j.ijantimicag.2014.03.016

Cited by 26 publications

(21 citation statements)

References 24 publications

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“…Fecal samples were diluted 10-fold to 10 Ϫ7 and inoculated on nonselective and selective agars, as described previously (8,9). The aerobic agar plates were incubated for 24 h at 37°C and the anaerobic plates were incubated for 48 h at 37°C in anaerobic jars (GasPak; BBL, Baltimore, MD, USA).…”

Section: Methodsmentioning

confidence: 99%

Ecological Effect of Ceftaroline-Avibactam on the Normal Human Intestinal Microbiota

Rashid

Rosenborg

Panagiotidis

et al. 2015

Antimicrob Agents Chemother

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Ceftaroline-avibactam is a new combination of the antibiotic ceftaroline with a novel non-␤-lactam ␤-lactamase inhibitor, avibactam. The purpose of the present study was to investigate the effect of ceftaroline-avibactam on the human intestinal microbiota. Fourteen healthy volunteers received ceftaroline-avibactam (600 mg ceftaroline fosamil and 600 mg avibactam) intravenously over 2 h every 8 h on days 1 to 6 and as a single dose on day 7. Fecal samples were collected on day ؊1 (within 24 h of the first infusion on day 1) and on days 2, 5, 7, 9, 14, and 21. Escherichia coli numbers decreased during the study and normalized on day 21. An increased number of Klebsiella bacteria appeared on day 14 and normalized on day 21. The number of other enterobacteria decreased during the study, and the number of enterococci decreased from days 2 to 7 and normalized on day 9. Candida numbers increased from days 5 to 9 and normalized after day 14. The number of lactobacilli decreased during the study and recovered on day 14. The number of bifidobacteria decreased on day 2 and normalized on day 21. The number of Bacteroides bacteria was unchanged. Clostridium difficile numbers decreased on days 7 and 9 and increased on days 14 and 21. A toxigenic C. difficile strain was detected in one volunteer on day 21 with no reported adverse events. Plasma samples were collected on days

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Section: Methodsmentioning

confidence: 99%

Ecological Effect of Ceftaroline-Avibactam on the Normal Human Intestinal Microbiota

Rashid

Rosenborg

Panagiotidis

et al. 2015

Antimicrob Agents Chemother

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“…Nasal swabs were obtained by the study personal according to the study design for microbiological analyses [21]. A swab was carefully inserted into each nostril and gently rolled five times.…”

Section: Nasal Samplingmentioning

confidence: 99%

Development of antimicrobial resistance in the normal anaerobic microbiota during one year after administration of clindamycin or ciprofloxacin

2015

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“…For clindamycin no EUCAST breakpoint was available and the CLSI breakpoint was used [23]. For MCB3681 a recommended breakpoint (4 mg/l) was used [25]. For ciprofloxacin and linezolid no breakpoints were available in the EUCAST and CLSI documents and therefore ciprofloxacin and linezolid breakpoints (8 and >4 mg/l respectively) were used based on literature recommendations [26,27].…”

Section: Antimicrobial Susceptibilitymentioning

confidence: 99%