Industrial sustainability is a vital issue in pursuing the long-term development of industrial systems. This
paper utilizes the existing Ecological Input−Output Analysis (EIOA) method, in combination with known
and established environmental (mass intensity) and economic (gross profit) sustainability metrics, to (i) create
a systematic analysis methodology capable of evaluating various decisions, which are made by individual
plant management for the benefit of their own company, and (ii) determine which option results in the best
route for improving sustainable development, at the plant, industry, and regional levels. Such information
will be valuable for the synergistic sustainability improvements of both individual entities as well as industrial
regions. To demonstrate the efficacy of this methodology, a case study involving a network of different
industries is presented. Sustainability of the base case and two modified cases is assessed. The one with the
highest positive environmental and economic sustainability impact is recommended.