Ecological state of colon cavitary microbiota in patients with chronic course of viral hepatitis c

Abstract

The article presents results of microbiological examination of 72 samples of colon contents of patients with chronic hepatitis C (control group is consisted of 87 samples of colon contents of the healthy people) and studied ecological changes in taxonomic composition of the investigated biotope. It has been established that patients with chronic hepatitis C form a tendency to elimination of Bifidobacteria and Lactobacilli from colon cavity (decrease in the index of constancy on 9.94 % and frequency of occurrence on 57.14 %), as well as Eubacteria (on 3,88 % and by 2 times, respectively) and an increase in the persistence of Peptostreptococci, Clostridia, Proteus, Staphylococci and yeast-like fungi of the genus Candida, which creates conditions for contamination and persistence in the investigated biotope of pathogenic and conditionally pathogenic Enterobacteria (EPEC, E. coli Hly+, E. coli Lac-, Cytrobacter, Enterobacter, Serratia), Peptococcus.

The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients

“…Soluble vascular cell adhesion molecule-1 (sVCAM-1) promotes inflammatory cells adhesion to the vascular endothelium and facilitates its migration through the endothelium membrane (Dörr et al 2012;Tchalla et al 2015Tchalla et al , 2018. Some evidence prove that these processes might be at least partially genetically determined by genes regulating RAAS or NO activity or code the enzymes' expression or synthesis, or associate with hypertrophy and remodeling of vascular smooth muscles (Sydorchuk et al 2013(Sydorchuk et al , 2015(Sydorchuk et al , 2020aJi et al 2017;Pimphen Charoen et al 2019;Smyth et al 2019;Dzhuryak et al 2020;Tegegne et al 2020;Repchuk et al 2021;Semianiv et al 2021). However, the mechanisms that orchestrate the balance between NO and EDCF, genetic predisposition to endothelial dysfunction in hypertensive patients still remain to be determined.…”