Ecological study of hantavirus infection in wild rodents in an endemic area in Brazil

Oliveira, Renata Carvalho de; Gentile, Rosana; Guterres, Alexandro; Fernandes, Jorlan; Teixeira, Bernardo Rodrigues; Vaz, Vanderson Corrêa; Valdez, Fernanda Pedone; Vicente, Luciana Helena Bassan; Costa-Neto, Sócrates Fraga da; Bonvicino, Cibele Rodrigues; D’Andrea, Paulo Sérgio; Lemos, Elba Regina Sampaio de

doi:10.1016/j.actatropica.2013.11.016

Cited by 24 publications

(18 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 Furthermore, the occurrence of JUQV-like infection in two different genera of hosts suggests a potential adaptation of this genotype to genetically distinct rodent species, as previously observed in the central and southern regions of Brazil, where distinct rodent species, A. montensis, Akodon paranaensis, Oligoryzomys mattogrossae (fornesi), Oligoryzomys Judex, and Thaptomys nigrita have been identified as being naturally infected with JUQV. [19][20][21][22] In this study, the cursor grass mouse was the most abundant species identified and has adapted to exist in primary and secondary forests, especially in the transition area between Atlantic Forest and Cerrado areas in southeastern Brazil. It is a generalist species that occurs near human habitation, as does the black-footed pygmy rice rat (O. nigripes).…”

Section: Resultsmentioning

confidence: 89%

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Oliveira

Guterres

Teixeira

et al. 2017

The American Society of Tropical Medicine and Hygiene

Self Cite

View full text Add to dashboard Cite

We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. Antibody prevalence was 6.9%. The circulation of a single genotype, the Juquitiba hantavirus, carried by two rodent species, black-footed pigmy rice rat () and cursor grass mouse (), was shown by analysis of the nucleotide sequences of the S segment. Juquitiba hantavirus circulates in rodents of various species, but mainly in the black-footed pigmy rice rat. HPS is a newly recognized clinical entity in Rio de Janeiro State and should be considered in patients with febrile illness and acute respiratory distress.

show abstract

Section: Resultsmentioning

confidence: 89%

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Oliveira

Guterres

Teixeira

et al. 2017

The American Society of Tropical Medicine and Hygiene

Self Cite

View full text Add to dashboard Cite

show abstract

“…Temperature can affect vegetation growth [29] and the survival rate of rodents [85], with mild temperatures (10–25°C) being most favorable for rodent breeding [86]. Additionally, reservoir rodents normally exhibit a peak in hantavirus infection during warmer months [87; 88; 89; 90], probably because high temperature leads to greater aerosolization of the virus and higher rates of inhalation by both humans and rodents [12; 13]. At present there are no data available on the effects of temperature on HPS virus survival, but laboratory experiments found that Puumala viruses (aetiological agent of Hantavirus infection in Western Europe) can remain infectious for longer (i.e.12 to 15 days) at room temperature (23°C; 73°F) [91], losing their viability if kept at 37°C [91].…”

Section: Discussionmentioning

confidence: 99%

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

et al. 2016

View full text Add to dashboard Cite

Hantavirus Pulmonary Syndrome (HPS) is a disease caused by Hantavirus, which are negative-sense RNA viruses in the family Bunyaviridae that are highly virulent to humans. Numerous factors modify risk of Hantavirus transmission and consequent HPS risk. Human-driven landscape change can foster transmission risk by increasing numbers of habitat generalist rodent species that serve as the principal reservoir host. Climate can also affect rodent population dynamics and Hantavirus survival, and a number of social factors can influence probability of HPS transmission to humans. Evaluating contributions of these factors to HPS risk may enable predictions of future outbreaks, and is critical to development of effective public health strategies. Here we rely on a Bayesian model to quantify associations between annual HPS incidence across the state of São Paulo, Brazil (1993–2012) and climate variables (annual precipitation, annual mean temperature), landscape structure metrics (proportion of native habitat cover, number of forest fragments, proportion of area planted with sugarcane), and social factors (number of men older than 14 years and Human Development Index). We built separate models for the main two biomes of the state (cerrado and Atlantic forest). In both biomes Hantavirus risk increased with proportion of land cultivated for sugarcane and HDI, but proportion of forest cover, annual mean temperature, and population at risk also showed positive relationships in the Atlantic forest. Our analysis provides the first evidence that social, landscape, and climate factors are associated with HPS incidence in the Neotropics. Our risk map can be used to support the adoption of preventive measures and optimize the allocation of resources to avoid disease propagation, especially in municipalities that show medium to high HPS risk (> 5% of risk), and aimed at sugarcane workers, minimizing the risk of future HPS outbreaks.

show abstract

“…Little scientific information is available regarding the phenomenon of “ratadas” associated with bamboo flowering in Brazil. An ecological study on the population dynamics of rodent hantavirus reservoirs in southern Brazil between 2004 and 2006 found an increase in the populations of O. nigripes and Thaptomys nigrita due to the flowering and fruiting of bamboos in the region [270]. …”

Section: Risk Factors For Hantavirus Transmission To Humansmentioning

confidence: 99%

Hantavirus Reservoirs: Current Status with an Emphasis on Data from Brazil

Oliveira

Guterres

Fernandes

et al. 2014

Viruses

Self Cite

View full text Add to dashboard Cite

Since the recognition of hantavirus as the agent responsible for haemorrhagic fever in Eurasia in the 1970s and, 20 years later, the descovery of hantavirus pulmonary syndrome in the Americas, the genus Hantavirus has been continually described throughout the World in a variety of wild animals. The diversity of wild animals infected with hantaviruses has only recently come into focus as a result of expanded wildlife studies. The known reservoirs are more than 80, belonging to 51 species of rodents, 7 bats (order Chiroptera) and 20 shrews and moles (order Soricomorpha). More than 80genetically related viruses have been classified within Hantavirus genus; 25 recognized as human pathogens responsible for a large spectrum of diseases in the Old and New World. In Brazil, where the diversity of mammals and especially rodents is considered one of the largest in the world, 9 hantavirus genotypes have been identified in 12 rodent species belonging to the genus Akodon, Calomys, Holochilus, Oligoryzomys, Oxymycterus, Necromys and Rattus. Considering the increasing number of animals that have been implicated as reservoirs of different hantaviruses, the understanding of this diversity is important for evaluating the risk of distinct hantavirus species as human pathogens.

show abstract

Ecological study of hantavirus infection in wild rodents in an endemic area in Brazil

Cited by 24 publications

References 55 publications

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

Hantavirus Reservoirs: Current Status with an Emphasis on Data from Brazil

Contact Info

Product

Resources

About