Ecology, Evolution and Control of Chagas Disease: A Century of Neglected Modelling and a Promising Future

Nouvellet, Pierre; Cucunubá, Zulma M.; Gourbière, Sébastien

doi:10.1016/bs.apar.2014.12.004

Cited by 59 publications

(50 citation statements)

References 132 publications

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“…Several control measures exist for Chagas disease, according to the different transmission scenarios (7,14,53), some of which have been applied by health organizations or administrative governments (54)(55)(56)(57)(58). Previous studies on the cost-effectiveness of Chagas disease management have been undertaken (59)(60)(61)(62), but the costs of different diagnostic methods have not been compared.…”

Section: Discussionmentioning

confidence: 99%

Serological Diagnosis of Chronic Chagas Disease: Is It Time for a Change?

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Serological Diagnosis of Chronic Chagas Disease: Is It Time for a Change?

et al. 2016

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“…On the other hand, Chagas disease, also named American trypanosomiasis, affects about 10 million people mainly in Latin America. This disease is produced by the protozoan parasite Trypanosoma cruzi that is transmitted to the mammalian host through the phases of triatomine bugs belonging to Triatoma, Rhodnius and Panstrongylus genus [3].…”

Section: Subgenus) As Well As L Mexicana and L Amazonensis (Membermentioning

confidence: 99%

Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities

Otero

García

Palacios

et al. 2017

European Journal of Medicinal Chemistry

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The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evaluated against amastigotes forms of L. (V) panamensis, which is the most prevalent Leishmania species in Colombia, and against Trypanosoma cruzi, which is the pathogenic species to humans. Cytotoxicity was evaluated against human U-937 macrophages. Eight compounds were active against L. 26 and 28, the remaining compounds were toxic for mammalian cells, yet they have potential to be considered as candidates for anti-trypanosomal and anti-leishmanial drug development. The activity is dependent on the length of the alkyl linker with compound 19, bearing a four-carbon alkyl chain, the most performing hybrid. In general, hydroxyl groups increase both activity and cytotoxicity and the presence of the double bond in the side chain is not decisive for cytotoxicity and anti-protozoal activity.

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“…These are parasitic diseases caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi) and Leishmania species. These diseases affect more than 10 million people worldwide (Alvar et al, 2012;Nouvellet et al, 2015) L. (V) panamensis is one of the most prevalent Leishmania species involved in human cases of cutaneous leishmaniasis in Colombia (Alvar et al, 2012). Current chemotherapies are based on old drugs, pentavalent antimonials (meglumine antimoniate and sodium stibogluconate) to treat cutaneous leishmaniasis and nitroaromatic compounds (benznidazole and nifurtimox) for treatment of Chagas disease.…”

Section: -21 Aa 1226 Medellín Colombiamentioning

confidence: 99%

Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids

et al. 2017

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We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids. The synthesized compounds were evaluated against amastigotes forms of L. (V) panamensis which is the most prevalent Leishmania species in Colombia and Trypanosoma cruzi which is the major pathogenic species to humans. respectively. All hybrids compounds showed better activity than the anti-leishmanial drug meglumine antimoniate. Compounds 20 and 23 showed higher actives than benznidazole, the current antitrypanosomal drug. Although these compounds showed toxicity for mammalian U-937 cells, still have potential to be considered as candidates to antileishmanial or trypanocydal drug development.

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Ecology, Evolution and Control of Chagas Disease: A Century of Neglected Modelling and a Promising Future

Cited by 59 publications

References 132 publications

Serological Diagnosis of Chronic Chagas Disease: Is It Time for a Change?

Serological Diagnosis of Chronic Chagas Disease: Is It Time for a Change?

Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities

Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids

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