Ecology of Mooren's ulcer in Nigeria

Majekodunmi, AA

doi:10.1007/bf01886619

Cited by 21 publications

(9 citation statements)

References 7 publications

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“…[30,31] It is a type of peripheral ulcer usually associated with autoimmune disease or immunological reactions to mycobacterial and Staphylococcus aureus toxins. The present study recorded eight eyes with Mooren's ulcer in seven male and one female patients.…”

Section: Discussionmentioning

confidence: 99%

Corneal ulcers in a tertiary hospital in Northern Nigeria

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Corneal ulcers in a tertiary hospital in Northern Nigeria

et al. 2013

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“…6 Since the earliest descriptions of Mooren's ulcer, [7][8][9][10] much of what is known of the demographics, history and clinical presentation of this condition has been gleaned from a relatively limited number of small case series and isolated case reports. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Liberal interpretation of these studies has given rise to widely held concepts regarding age, gender and race as predictors of severity and laterality, views that have been questioned in light of the varied composition and small size of these reported cohorts. 30 31 We present here the demographic, historical and clinical characteristics of a large cohort of patients with Mooren's ulcer seen at Aravind Eye Hospital, Madurai, Tamil Nadu, India.…”

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Clinical characteristics of Mooren's ulcer in South India

Srinivasan

Zegans

Zelefsky

et al. 2006

British Journal of Ophthalmology

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Aim: To describe the clinical characteristics at presentation of a large cohort of patients with Mooren's ulcer in South India. Methods: The medical records of patients with Mooren's ulcer examined in the cornea clinic at Aravind Eye Hospital Madurai, Tamil Nadu, India, over a 10-year period were reviewed in this retrospective observational case series. Results: The cohort contained 242 eyes of 166 patients. All patients were from South India, and men outnumbered women by a ratio of 4.7:1. The median and mean ages at presentation were 65 and 61 years, respectively, with a range of 13-95 years. One eye was affected in 90 of 166 (54%) patients. Visual acuity in the affected eye at presentation ranged from 6/6 to light perception, and was 6/12 or better in 34 of 242 (14%) eyes, between 6/12 and 3/60 in 168 (69%) eyes, and worse than 3/60 in 40 (17%) eyes. Partial peripheral corneal ulceration was observed in 222 (92%) eyes, complete peripheral corneal ulceration was observed in 15 (6%) eyes and total corneal ulceration was observed in 5 (2%) eyes. For those 222 eyes with partial peripheral ulceration, 152 (68%) showed temporal involvement, 129 (58%) showed nasal involvement, 116 (52%) showed inferior involvement and 30 (14%) showed superior involvement. Perforation was observed in 26 (11%) eyes, and was more common in eyes with peripheral as compared with total ulceration (p,0.001). Identified risk factors in the cohort included evidence of prior corneal surgery (22%), corneal trauma (17%) and corneal infection (2%). Conclusions: Mooren's ulcer is a rare and potentially blinding eye condition observed not infrequently in the cornea clinic at Aravind Eye Hospital. Men are affected more often than women and may present with either unilateral or bilateral disease. Perforation is observed in approximately 1 in 10 affected eyes at presentation and occurs most often in the setting of peripheral ulceration. The occurrence of prior corneal surgery, trauma or infection in nearly one third of patients supports theories of exposure to corneal antigen in the pathogenesis of this disorder.

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“…1 Additional reports from Africa have confirmed an association of Mooren's ulcer with helminthic infection. 2,3 Kuriakose suggested that the ulcer is the result of corneal response to a toxin secreted by microfilariae. 1 We suggest that there is an autoimmune response in the cornea triggered by the host's response to a nematode antigen that cross-reacts with a specific corneal protein.…”

Section: Discussionmentioning

confidence: 99%