Economic burden of endometriosis

Gào, Xīn; Outley, Jackie; Botteman, Marc; Spalding, James; Simon, James A.; Pashos, Chris L.

doi:10.1016/j.fertnstert.2006.06.015

Cited by 248 publications

(169 citation statements)

References 41 publications

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“…Endometriosis shows different prevalence among ethnic groups, affecting 2-22% of women of reproductive age [2]. Susceptibility to endometriosis is influenced by a complex interaction of immunologic, hormonal, and genetic factors [3].…”

Section: Introductionmentioning

confidence: 99%

p53 codon 72 polymorphism and endometriosis: a meta-analysis

Jia

Chan

et al. 2012

Arch Gynecol Obstet

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Section: Introductionmentioning

confidence: 99%

p53 codon 72 polymorphism and endometriosis: a meta-analysis

Jia

Chan

et al. 2012

Arch Gynecol Obstet

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“…Endometriose (EM) ist eine Erkrankung von Frauen im reproduktionsfähigen Alter, die über ihre Leitsymptome Dysmenorrhö, Dyspareunie, Dyschezie, Dysurie, zyklische und azyklische Unterbauchschmerzen, Blutungsstörungen und Fertilitätsbeeinträchtigung extreme menschliche, klinische und volkswirtschaftliche Relevanz hat [13,14].…”

Section: Ist Ein Nichtinvasives Testverfahren Sinnvoll?unclassified

Endometriose und Nervenfasern

et al. 2010

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“…The risk of developing endometriosis is between 5 and 8% in first-degree relatives; it is a progressive disease in 40 to 50% of all affected women (Bischoff and Simpson, 2004). Recurrence is frequently observed after surgery or after drug therapy, especially in women with moderate to severe endometriosis (Gao et al, 2006). Susceptibility to the disease varies across ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil)

Silva

Moura

2016

Genet. Mol. Res.

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ABSTRACT. In healthy women, intra-and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response. Several genetic, immunological, and environmental factors contribute to this complex process. In this study we examined 6 polymorphisms for 6 different genes (p53; estrogen receptor β; progesterone receptor; GSTM1; GSTT1; CYP1A1). We obtained polymorphic genotype frequencies of all genes for 50 patients and analyzed them using the Fisher exact test or G test. Initially, we analyzed the genes in groups of 2, followed by 3. We found a significant association between polymorphisms in 6 pairs of genes (p53-ERβ showed 5.9-times higher frequency in the experimental group, p53-GSTM1 showed 2.39 times higher, 65.5% patients showed p53-CYP1A1 polymorphism, ERβ-PROGINS showed 3.0-times higher frequency, while 31.25% patients showed GSTM1-PROGINS and GSTT1-CYP1A1 polymorphism). Positive results were found in 15 situations when genes were analyzed in groups of 3; the most significant result corresponded to polymorphisms of p53, ERβ and GSTM1 seen in 20%; PROGINS, ERβ and GSTM1 in 18%; and p53, ERβ and PROGINS in 12% patients. The results indicate that the presence of polymorphisms in more than one endometriosis-related gene is associated with onset of disease and progression. Future studies should focus on these genes to understand their inter-relationships and explore the possibility of developing new diagnostic techniques based on molecular markers.

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Economic burden of endometriosis

Cited by 248 publications

References 41 publications

p53 codon 72 polymorphism and endometriosis: a meta-analysis

p53 codon 72 polymorphism and endometriosis: a meta-analysis

Endometriose und Nervenfasern

Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil)

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