Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector

Thomann, Beat; Tschopp, A.; Magouras, Ioannis; Meylan, Mireille; Schüpbach‐Regula, Gertraud

doi:10.1016/j.prevetmed.2017.05.020

Cited by 26 publications

(30 citation statements)

References 16 publications

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“…However, when these six studies were compared with the other incorporated studies ( n = 13, see Table S4) which do not use the stochastic model by Gunn et al, (), the following differences were identified: the mean annual production losses per animal was approximately €7.00 higher; different ex‐ante or ex‐post methods were used, while the studies based on the model by Gunn et al, () are all prediction studies; varying assumptions about the effectiveness of mitigation options (e.g., some studies assumed 100% efficacy of vaccine which caused no spread of BVDV and thus no production losses; Santman‐Berends, Mars, Duijn, & Schaik, ), and about the transmission probabilities. For instance, one study assumed that 60% of all birth of PI animals in the herds will not lead to losses from BVDV infections (Santman‐Berends et al, ) or other studies taken a constant transmission rate into account (Pasman et al, ), or neglected infection of naïve herds, or production losses by infected calves, youngstock, or transiently‐infected animals such as by Pasman et al, (), Reichel, Hill, and Voges (), Santman‐Berends et al, (), Thomann et al, () and Marschik et al, (). The latter could lead to underestimation of the true economic impact.…”

Section: Discussionmentioning

confidence: 99%

“…Further, the majority of the studies assume different levels of discounting rates and the higher the discounting rate, the lower the level of the current production losses in the studies. The six studies based on the model by Gunn et al, () took immunosuppression into account, whereas the other studies (such as the study by Thomann et al, () and Marschik et al, ()) did not use the BVDV model by Gunn et al, () neglected it. Further difference between applied BVDV models are given in the review article by Viet, Fourichon, and Seegers ().…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological factors and mitigation measures influencing production losses in cattle due to bovine viral diarrhoea virus infection: A meta‐analysis

Pinior

Garcia

Minviel

et al. 2019

Transbound Emerg Dis

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Infection with bovine viral diarrhoea virus (BVDV) is associated with a loss in productivity in cattle farms. Determining which factors influence monetary losses due to BVDV could facilitate the implementation of mitigation measures to reduce the burden of BVDV. Mixed‐effect meta‐analysis models were performed to estimate the extent to which the costs of mean annual BVDV production losses per animal may be influenced by epidemiological factors such as BVDV introduction risk, initial prevalence, viral circulation intensity and circulation duration (trial 1). Additionally, changes in mean annual BVDV production losses per animal due to specific mitigation measures (i.e., biosecurity, vaccination, testing and culling, cattle introduction or contact with neighbouring cattle herds) were analysed (trial 2). In total, 19 studies were included in the meta‐analysis to assess mean annual BVDV production losses. The mean annual direct losses were determined to be €42.14 per animal (trial 1). The multivariate meta‐regression showed that four of the previously mentioned epidemiological factors significantly influenced the mean annual BVDV production losses per animal. Indeed, the per animal costs increased to €67.19 when these four factors (trial 1) were considered as “high or moderate” compared to “low”. The meta‐regression analysis revealed that implementation of vaccination and biosecurity measures were associated with an 8%–12% and 28%–29% decrease in BVDV production losses on average, respectively, when simulated herds were compared with or without such mitigation measures (trial 2). This reduction of mean annual BVDV production losses per animal due to mitigation measures was partially counteracted when farmers brought new cattle on to farm or allowed contact with neighbouring cattle herds. The influencing mitigation factors presented here could help to guide farmers in their decision to implement mitigation strategies for the control of BVDV at farm level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epidemiological factors and mitigation measures influencing production losses in cattle due to bovine viral diarrhoea virus infection: A meta‐analysis

Pinior

Garcia

Minviel

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…Eradication of the virus is possible at the farm and regional levels, with eradication trials in several European countries having proved successful. 8,[14][15][16] However, comparative Australian data concerning BVDV eradication and control trials are lacking, and it is difficult to extrapolate European data due to inherent differences in their production systems. The specific control approach differs between countries, but all feature three main components: elimination of PI animals, biosecurity to prevent reinfection and disease surveillance.…”

mentioning

confidence: 99%

Knowledge, attitudes and management of bovine viral diarrhoea virus among eastern Australian cattle producers: results from a 2013 cross‐sectional study

et al. 2020

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Bovine viral diarrhoea virus (BVDV) is an economically significant disease affecting the Australian cattle industry, with losses stemming from decreased production and reproductive performance and control costs. However, these losses can be difficult to appreciate, particularly in endemic regions. Overall, there is a variable but high herd‐level seroprevalence in Australia. Despite a potentially high financial burden of the disease, the onus for control ultimately falls on producers and strategies employed will vary between regions. A cross‐sectional study, using a postal survey, was conducted in 2013 to evaluate the BVDV knowledge, attitudes and management practices utilised by Australian cattle producers. A total of 192 producers participated in the study, and results indicate that knowledge and attitudes towards disease risk are variable and can be improved. Producer knowledge of how persistently infected (PI) animals are produced was higher than that of disease outcomes or transmission pathways. Implementation of biosecurity practices was limited, with approximately half of respondents employing quarantine procedures for introduced stock and only 2% indicating they would antigen test introduced stock for BVDV. Approximately a third (36%) of producers reported engaging in BVDV control, with the majority of these using vaccination strategies over deliberate exposure to a PI. Knowledge of and engagement with BVDV control was positively influenced by the producer relationships with veterinarians. Findings from this study suggest that building on education and delivering a consistent message among stakeholders would likely improve producer awareness and understanding in relation to BVDV and support decision making in BVDV management.

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“…Un estudio realizado recientemente en Suiza estimó que las pérdidas financieras anuales en rodeos infectados con el VDVB fueron de CHF 85-89 por vaca lechera y CHF 1337-2535 para una granja promedio, dependiendo del tipo de producción. La mediana del valor actual neto (VAN) se estimó en CHF 44.9 millones (90% del rango central: CHF 13.4 millones a 69.4 millones) [48]. En Argentina, un estudio realizado en 2013 [49] ha estimado que un retraso de un mes en el 20% de las vaquillonas de primera lactancia en reposición (calculan un 30% como tasa de reposición), una disminución de la producción de leche en las transitoriamente afectadas y una caída del 20% de producción (3 semanas) en las infectadas.…”

Section: Impacto Económico De La Enfermedadunclassified

A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity

Quintana

Barone

Forlenza

et al. 2018

Journal of Virological Methods

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Low-cost high-throughput methods applicable to any virus strain are required for screening antiviral compounds against multiple field strains. Colorimetric cell-viability assays are used for this purpose as long as the viruses are cytopathic (CP) in cell culture. However, bovine viral diarrhoea virus (BVDV) strains circulating in the field are mostly non-cytopathic (NCP). An In Cell-ELISA aimed to measure viral infectivity by detecting a conserved protein produced during viral replication (non-structural protein 3, "NS3") was developed. The ELISA is performed without harvesting the cells, directly on the 96-wells culture plate. NS3 In Cell-ELISA was tested for its ability to assess BVDV-specific antiviral activity of recombinant bovine type I and III IFNs. Results correlated to those measured by qRT-PCR and virus titration. NS3 In Cell-ELISA was also efficient in estimating the IC50 of two compounds with different antiviral activity. Estimation of the 50% inhibition dose of each IFN using six BVDV strains of different biotype and genotype showed that CP strains were more susceptible to both IFNs than NCP, while type 2 NCP viruses were more sensitive to IFN-I. The In Cell-ELISA format using a detector antibody against a conserved non-structural protein can be potentially applied to accurately measure infectivity of any viral strain.

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Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector

Cited by 26 publications

References 16 publications

Epidemiological factors and mitigation measures influencing production losses in cattle due to bovine viral diarrhoea virus infection: A meta‐analysis

Epidemiological factors and mitigation measures influencing production losses in cattle due to bovine viral diarrhoea virus infection: A meta‐analysis

Knowledge, attitudes and management of bovine viral diarrhoea virus among eastern Australian cattle producers: results from a 2013 cross‐sectional study

A direct high-throughput in Cell-ELISA for measuring infectivity of cytopathic and non-cytopathic bovine viral diarrhoea virus strains applied to the assessment of antiviral activity

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