Economic evaluation of vancomycin-resistant enterococci (VRE) control practices: a systematic review

MacDougall, Colin; Johnstone, Jennie; Prematunge, Chatura; Adomako, Kwaku; Nadolny, Emily; Truong, Eva; Saedi, Arezou; Garber, Gary; Sander, Beate

doi:10.1016/j.jhin.2019.12.007

Cited by 21 publications

(16 citation statements)

References 25 publications

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“…Only one study used an analysis from a perspective other than that of a hospital, such as the patient perspective [52]. Second, as also found by MacDougall et al [18] none of the included studies estimated the societal costs of the four CBPs including: the infection prevention and control actions of the family, loved ones, caregivers and visitors. Third, in terms of the estimation, only three of the included studies clearly reported the date or the year of valuation of costs [50,52,54].…”

Section: Summary Of Evidencementioning

confidence: 99%

“…It also did not assess the effectiveness of the four CBPs (hand hygiene, hygiene and sanitation of surfaces and equipment, admission screening, and additional precautions) simultaneously. Finally, few systematic reviews have used discounting approaches to report their findings, for example see MacDougall [18], which would facilitate comparisons between studies, the year of investigation, currencies and economic evaluation methods.…”

Section: Introductionmentioning

confidence: 99%

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Economic analysis of healthcare-associated infection prevention and control interventions in medical and surgical units: systematic review using a discounting approach

Tchouaket¹,

Beogo²,

Sia³

et al. 2020

Journal of Hospital Infection

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Nosocomial or healthcare-associated infections (HCAIs) are associated with a financial burden that affects both patients and healthcare institutions worldwide. The clinical best care practices (CBPs) of hand hygiene, hygiene and sanitation, screening, and basic and additional precautions aim to reduce this burden. The COVID-19 pandemic has confirmed these four CBPs are critically important prevention practices that limit the spread of HCAIs. This paper conducted a systematic review of economic evaluations related to these four CBPs using a discounting approach. We searched for articles published between 2000 and 2019. We included economic evaluations of infection prevention and control of Clostridioides difficile-associated diarrhoea, meticillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and carbapenem-resistant Gram-negative bacilli. Results were analysed with cost-minimization, cost-effectiveness, cost-utility, cost-benefit and cost-consequence analyses. Articles were assessed for quality. A total of 11,898 articles were screened and seven were included. Most studies (4/7) were of overall moderate quality. All studies demonstrated cost effectiveness of CBPs. The average yearly net cost savings from the CBPs ranged from $252,847 (2019 Canadian dollars) to $1,691,823, depending on the rate of discount (3% and 8%). The average incremental benefit cost ratio of CBPs varied from 2.48 to 7.66. In order to make efficient use of resources and maximize health benefits, ongoing research in the economic evaluation of

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Section: Summary Of Evidencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Economic analysis of healthcare-associated infection prevention and control interventions in medical and surgical units: systematic review using a discounting approach

Tchouaket¹,

Beogo²,

Sia³

et al. 2020

Journal of Hospital Infection

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“…Enterococci are leading pathogens of nosocomial infections such as bacteraemia, intra-abdominal infections and surgical wounds, especially urinary tract infections [1]. With the antimicrobial agents being frequently used in clinical treatment, antibiotic-resistant enterococci, particularly multi-drug resistant enterococci isolates, such as vancomycin-resistant enterococci (VRE) and linezolidresistant enterococci (LRE) have emergence and spread all over the world [2,3].…”

Section: Introductionmentioning

confidence: 99%

Characterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018

Zhou

Sun

et al. 2020

BMC Infect Dis

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Background: Vancomycin-resistant Enterococcus spp. (VRE) have spread all over the world. The present study aims to investigate the species distribution, specimen type and susceptibilities of Enterococcal species collected from Nanjing Drum Tower Hospital from 2013 to 2018. Additionally, distribution of VRE and prevalence of van gene among VRE isolates were also analyzed. Methods: The susceptibilities of 3913 Enterococcus isolates were retrospectively investigated. Among these strains, 60 VRE strains were further anazlyed in this study. The minimum inhibitory concentrations (MICs) of the VRE strains towards vancomycin, teicoplanin and linezolid were determined by E-test. Polymerase chain reaction (PCR) and DNA sequencing were used to investigate the prevalence of van genes among VRE. Furthermore, the sequence types (STs) of VRE strains were explored by multi-locus sequence typing (MLST). Results: Among the 3913 enterococci isolates, Enterococcus faecalis (n = 1870, 47.8%) and Enterococcus faecium (1738, 44.4%) were the main isolates. These Enterococcus strains were mainly isolated from urine (n = 1673, 42.8%), followed by secretions (n = 583, 14.9%) and ascites (n = 554, 14.2%). VRE displayed a decreasing trend year by year. Molecular analysis revealed that 49 out of 60 VRE isolates carried vanA gene, 10 carried vanM, and 1 carried both vanA and vanM genes. Sixteen distinct STs were identified among the 58 VREM, with ST78 (n = 16), ST192 (n = 8) and ST570 (n = 7) being the most dominant ones.

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“…This clade can be distinguished by its increased number of mobile genetic elements, metabolic alternations and hypermutability [1]. All of these attributes led to the development of a flexible genome, which is now able to easily adapt to the changes of the surroundings [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…It is also crucial to describe the natural habitats of enterococci and their pathogenicity since these factors are really related to each other. When in their natural habitat -such as soil or gastrointestinal tract -enterococci are quite harmless, but in the presence of a hospital environment, where they are exposed to antibiotics, they usually start to mutate, and that is how they become multidrug-resistant pathogens [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease

2020

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AbstractThe constantly growing bacterial resistance against antibiotics is recently causing serious problems in the field of human and veterinary medicine as well as in agriculture. The mechanisms of resistance formation and its preventions are not well explored in most bacterial genera. The aim of this review is to analyse recent literature data on the principles of antibiotic resistance formation in bacteria of the Enterococcus genus. Furthermore, the habitat of the Enterococcus genus, its pathogenicity and pathogenicity factors, its epidemiology, genetic and molecular aspects of antibiotic resistance, and the relationship between these bacteria and bowel diseases are discussed. So-called VREfm – vancomycin resistant Enterococcus faecium and its currently rapidly growing resistance as well as the significance of these bacteria in nosocomial diseases is described.

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Economic evaluation of vancomycin-resistant enterococci (VRE) control practices: a systematic review

Cited by 21 publications

References 25 publications

Economic analysis of healthcare-associated infection prevention and control interventions in medical and surgical units: systematic review using a discounting approach

Economic analysis of healthcare-associated infection prevention and control interventions in medical and surgical units: systematic review using a discounting approach

Characterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018

The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease

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