Economical aspect of PET/CT – Guided diagnosis of suspected infective endocarditis in a patient with implantable cardioverter-defibrillator

Farkowski, Michał M.; Milkowski, Maciej; Dziuk, Mirosław; Pytkowski, Mariusz; Marciniak, M Bochenska; Kraska, Alicja; Szwed, Hanna; Sterliński, Maciej

doi:10.1016/j.hrtlng.2014.04.002

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…This is of particular significance in cases of IE in children and as such 18 F-FDG-PET/CT analysis is not advised. The associated costs of the procedure are much higher than those of TTE and TEE; however, such costs must be assessed in terms of prevention of secondary complications and reduced costs due to shortened in-hospital stay 86. Of significance is the technical aspects of the procedure, particularly relating to normal uptake of the tracer.…”

Section: Positron-emission Tomographymentioning

confidence: 99%

New diagnostic approaches in infective endocarditis

Millar

Habib

Moore

2016

Heart

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Section: Positron-emission Tomographymentioning

confidence: 99%

New diagnostic approaches in infective endocarditis

Millar

Habib

Moore

2016

Heart

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show abstract

“…12 The former (modified Duke) criteria still bear a high degree of diagnostic uncertainty regarded as suboptimal, in particular in patients with intracardiac prosthetic material. [12][13][14][15] Therefore, newer imaging techniques, in addition to echocardiography, are now part of the diagnostic workup for endocarditis. 12 These techniques include computed tomography (CT), 18 F-fluorodeoxyglucose positron emission tomography/lowdose CT (FDG-PET/CT), and leukocyte scintigraphy with single-photon emission computed tomography/lowdose CT.…”

Section: Introductionmentioning

confidence: 99%

Imaging infective endocarditis: Adherence to a diagnostic flowchart and direct comparison of imaging techniques

Gomes

Geel

Santing

et al. 2020

Journal of Nuclear Cardiology

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“…Positron emission tomography combined with computed tomography (PET CT) can play an important role in difficult cases of CIED-related infections, but published studies have focused on the outcomes and safety of this procedure, only briefly considering the economic aspects of this diagnostic test [11].…”

Section: Introductionmentioning

confidence: 99%

New diagnostic pathways urgently needed. Protocol of PET Guidance I pilot study: positron emission tomography in suspected cardiac implantable electronic device-related infection

et al. 2016

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A b s t r a c tBackground: Cardiovascular implantable electronic device (CIED) infection is a complication of increasing incidence. We present a protocol of an observational case control clinical trial "Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiac Implantable Electronic Device Infection, a Pilot Study -PET Guidance I" (NCT02196753). Aim:The aim of this observational clinical trial is to assess and standardise diagnostic algorithms for CIED infections (lead-dependent infective endocarditis, generator pocket infection, fever of unknown origin) with PET CT in Poland. Methods and results:Study group will consist of 20 patients with initial diagnosis of CIED-related infection paired with a control group of 20 patients with implanted CIEDs, who underwent PET CT due to other non-infectious indications and have no data for infectious process in follow-up. All patients included in the study will undergo standard diagnostic process. Conventional/standard diagnostic and therapeutic process will consist of: medical interview, physical examination, laboratory tests, blood cultures; imaging studies: echocardiography: transthoracic (TTE), and, if there are no contraindications transoesophageal, computed tomography scan for pulmonary embolism if indicated; if there are abnormalities in other systems, decisions concerning further diagnostics will be made at the physician's discretion. As well as standard diagnostic procedures, patients will undergo whole body PET CT scan to localise infection or inflammation. Diagnosis and therapeutic decision will be obtained from the Study Committee. Follow-up will be held within six months with control visits at three and six months. During each follow-up visit, all patients will undergo laboratory tests, two blood cultures collected 1 h apart, and TTE. In case of actual clinical suspicion of infective endocarditis or local generator pocket infection, patients will be referred for further diagnostics. Endpoints for the results assessment -primary endpoints are to standardise PET CT in the diagnostic process: sensitivity, specificity, positive predictive value, and negative predictive value of the diagnosis made by PET CT; secondary endpoints are: assessment of usefulness of PET CT for detection of remote infective complications (metastatic abscesses, infected pulmonary emboli), incidence of particular localisations of infection, influence of PET CT on therapeutic decision: confirmation or change of decision based on PET CT, safety and complications of diagnostic process of CIED-related infections with PET CT. Conclusions:Evaluation of PET CT use for device-related infections in a case control study may be conclusive and improve diagnostic pathway.

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Economical aspect of PET/CT – Guided diagnosis of suspected infective endocarditis in a patient with implantable cardioverter-defibrillator

Cited by 4 publications

References 10 publications

New diagnostic approaches in infective endocarditis

New diagnostic approaches in infective endocarditis

Imaging infective endocarditis: Adherence to a diagnostic flowchart and direct comparison of imaging techniques

New diagnostic pathways urgently needed. Protocol of PET Guidance I pilot study: positron emission tomography in suspected cardiac implantable electronic device-related infection

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