Economical saving due to prophylaxis in the prevention of surgical wound infection

Arjona, Manuel Fernández; Cabrera, Rafael; Sancha, Fernando Gómez; Nieto, Silvia Collado; Calero, J. Rey

doi:10.1007/bf00143996

Cited by 11 publications

(2 citation statements)

References 10 publications

(12 reference statements)

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“…The incidence of wound infection in clinical trials of patients undergoing colorectal surgery varies between 9.5% and 22% [ 4–8]. The reported rates in non‐trial patients undergoing elective colorectal surgery varies from 5% to 7.5% [ 9].…”

Section: Discussionsupporting

confidence: 80%

A multivariate analysis of the factors associated with wound infection after colorectal surgery

Platell

Hall

1999

Colorectal Disease

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Objectives Wound infection has been proposed as a key indicator of clinical outcome after colorectal surgery. The aim of this study was to identify risk factors that were associated with wound infections in patients undergoing either emergency or elective colonic resections. Patients and methods We prospectively evaluated 251 patients admitted to Royal Perth Hospital over a 12‐month period. All patients received prophylactic peri‐operative antibiotics and were reviewed for 6 weeks post‐operatively. Wound infection was defined as either the presence of pus or a serous discharge containing pathogenic bacteria. We evaluated the relationship between 40 independent variables and the incidence of wound infection. Results There were 124 males and 127 females, of median age 68 years (range 14–90 years). The overall incidence of wound infection was 12%. Multiple logistic regression identified the presence of shock (odds ratio (OR) 14.6, P=0.05), atelectasis (OR 3.9, P=0.02), and number of days on antibiotics before surgery (OR 1.2, P=0.02) as significant independent variables. Conclusion These results suggest that the factors which were most often associated with wound infection were those that are indicative of either extensive disease or poor general health. The presence of a stoma and colonic perforation were not strong independent associations with wound infection.

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Section: Discussionsupporting

confidence: 80%

A multivariate analysis of the factors associated with wound infection after colorectal surgery

Platell

Hall

1999

Colorectal Disease

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“…Cost benefit ratio was 1/17. Hence the right prophylaxis is of utmost importance in order to avoid the development of infections 15 . Wound infection reported in literature for clean wound is between 1.5% and 4% (16,17) .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Effect of Single-Dose Prophylactic Antibiotic versus Conventional Antibiotic Therapy in Selected Clean Surgical Cases in A Tertiary Care Centre

Basavarajappa¹

2018

jmscr

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This tertiary care hospital based prospective study was performed to compare the effect of single dose prophylactic versus conventional antibiotic therapy in clean surgical cases operated in SSIMS&RC, Davangere. A total of 100 cases were studied, male patients were more compared to females with ratio of 3:2, with mean age of 42.7 years, all clean surgical cases were operated, with highest being inguinal hernia 31%. In this study 6% of cases in group-II and 2% case in group-I had postoperative infection, with most common organism isolated being staphylococcus aureus. This study highlights the judicious use of prophylactic antibiotics in order to prevent emergence of antibiotic resistance and to reduce prolonged hospital stay and cost incurred due to antibiotics.

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Transferability indices for health economic evaluations: methods and applications

et al. 2009

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In this paper, we have elaborated an index in two phases to measure the degree of transferability of the results of the economic evaluation of health technologies. In the first phase, we have considered the objective factors (critical and non-critical) to derive a general transferability index, which can be used to measure this internal property of the studies of economic evaluation applied to health technologies. In the second phase, with a more specific index, we have measured the degree of applicability of the results of a given study to a different setting. Both indices have been combined (arithmetic and geometric mean) to obtain a global transferability index. We have applied the global index to a sample of 27 Spanish studies on infectious diseases. We have obtained an average value for the index of 0.54, quite far from the maximum theoretical value of 1. We also found that 11 studies lacked some critical factor and were directly deemed as not transferable.

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Economical saving due to prophylaxis in the prevention of surgical wound infection

Cited by 11 publications

References 10 publications

A multivariate analysis of the factors associated with wound infection after colorectal surgery

A multivariate analysis of the factors associated with wound infection after colorectal surgery

A Comparative Study of Effect of Single-Dose Prophylactic Antibiotic versus Conventional Antibiotic Therapy in Selected Clean Surgical Cases in A Tertiary Care Centre

Transferability indices for health economic evaluations: methods and applications

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