High pressure processing (HPP) is a well established operation nowadays. In the last decades its potential increased from a promising new technology generally focused on natural products extraction with a generalized lack of scientific knowledge and technical skills, to a wide range of specific applications involving catalytic reactions, biomass conversion, particle formation, drug delivery or biomedical applications (Caputo et al. 2013). One of the most promising applications of high pressure processing concerns food, nutraceutical and pharmacy industry. In these fields theoretical, operative and technical aspects are well known nowadays. Thermodynamic and kinetic information is generally available for a large number of compounds and systems; and the behaviour of the process is usually well known and different models can be used to predict and optimize the results.Simple extracts to final products can be obtained using different isolation strategies such as extraction, concentration, fractionation, impregnation, reaction, precipitation (Perrut 2000;Brunner 2012). The procedure can be performed in single step or multistage extraction, column fractionation or multiphase reactions in devices from cm 3 to m 3 . No limitation exists about physical nature of samples -HPP can be used coupled to classical refining or treatments or even a sequence of processes in "one pot" procedure can be performed. As regarding final product production advantages, HPP can obtain very narrow size distribution particles, tuned dosage and delivery capacity and different presentations like microencapsulation that can increase the solubility and reduce the dosage of drugs. In addition, HPP products are well characterized and based in research and innovative processes