Ecotoxicity analysis of cholinium-based ionic liquids to Vibrio fischeri marine bacteria

Ventura, Sónia P. M.; Silva, Francisca A. e; Gonçalves, Ana M.M.; Pereira, Joana Luísa; Gonçalves, Fernando; Coutinho, João A. P.

doi:10.1016/j.ecoenv.2014.01.003

Cited by 197 publications

(140 citation statements)

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“…In fact, a series of choline (Petkovic et al, 2010;Hou et al, 2013;Ventura et al, 2014) or choline-like (Pernak and Chwala, 2003) salts have been proven to be antimicrobial, and many ILs have been reported to exert anti-microbial activities towards a broad range of microorganisms including bacteria, yeasts and algae (Pham et al, 2010;Samori`, 2011). Quaternary Ammonium Compounds (QACs), such as cetrimonium bromide and benzalkonium chloride, have been widely used as antiseptics and disinfectants (Samori`, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…Petkovic et al (2010) have discovered that the toxicity of a series of cholinium alkanoates towards filamentous fungi increased with the elongation of the linear chain in the anion. Recently, Ventura et al (2014) have also demonstrated that the toxicity of 10 different cholinium salts varied as a function of the anion. While most of these compounds can be classified as ''practically harmless'', their eco-toxicity is actually higher than that of common organic solvents such as chloroform or dichloromethane, and some have toxicities comparable to, or even higher than, that of reference pesticides such as atrazine (Ventura et al, 2014).…”

Section: Discussion About the Toxic Effects Of Dess On Plants And Animentioning

confidence: 97%

“…Recently, Ventura et al (2014) have also demonstrated that the toxicity of 10 different cholinium salts varied as a function of the anion. While most of these compounds can be classified as ''practically harmless'', their eco-toxicity is actually higher than that of common organic solvents such as chloroform or dichloromethane, and some have toxicities comparable to, or even higher than, that of reference pesticides such as atrazine (Ventura et al, 2014). The above two studies have revealed that the salts seemed to be more toxic with an increase in the anion's lipophilicity, which is represented by its log K ow value (the logarithm of the 1-octanol/water partition coefficient).…”

Section: Discussion About the Toxic Effects Of Dess On Plants And Animentioning

confidence: 97%

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Assessing the toxicity and biodegradability of deep eutectic solvents

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Section: Resultsmentioning

confidence: 99%

Section: Discussion About the Toxic Effects Of Dess On Plants And Animentioning

confidence: 97%

Section: Discussion About the Toxic Effects Of Dess On Plants And Animentioning

confidence: 97%

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Assessing the toxicity and biodegradability of deep eutectic solvents

et al. 2015

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“…16,17,20,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Table S1 of the ESI. † While the other descriptors were obtained without the need of any geometry optimization process, the QTMS parameters were derived from the ab initio based optimized geometry at the HF/6-31G(d) level of theory, and were limited to only cations.…”

Section: The Dataset and Descriptorsmentioning

confidence: 99%

Development of predictive QSAR models for Vibrio fischeri toxicity of ionic liquids and their true external and experimental validation tests

et al. 2016

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Despite possessing an interesting chemical nature and tuneable physicochemical properties, ionic liquids (ILs) must have their ecotoxicity tested in order to be commercialized. The water solubility of ILs allows their easy access to the aquatic compartment of the ecosystem creating a potential hazard to aquatic organisms. Hence, it is relevant to design ionic liquids with lower toxicity while keeping the desired properties of interest. Considering the possibility of an enormous number of combinations of different cations and anions, a rational guidance for the structural design of ionic liquids is essential in order to prioritize the synthesis as well as testing of selected molecules only. Predictive in silico models, such as quantitative structure-activity relationship (QSAR) models, can play a pivotal role in exploring the important chemical attributes contributing to the response activity. These models may then lead to the design of novel ionic liquids. The present study aims at developing predictive QSAR models for the ecotoxicity of ionic liquids using the bacteria Vibrio fischeri as an indicator response species. Instead of a single model, here we have used multiple models to capture more complete structural information of ionic liquids for toxicity towards Vibrio fischeri. The derived chemical attributes have been implemented in designing new analogues, some of which have been synthesized and had their ecotoxicity tested for the same model organism. The predictive QSAR models reported here can be used for ecotoxicity prediction of new IL chemicals and for data-gap filling. Moreover, the synthesized low-toxic ILs could be considered for evaluation as well as for application in suitable processes serving the purpose of industry and academia.

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“…Cairan ionik bersuhu kamar (RTILs) adalah kandidat yang menjanjikan yang dapat memenuhi persyaratan diatas (Ventura et al, 2014) yang sepenuhnya terdiri dari ion kation organik stabil dan anion anorganik atau organik, dapat dilihat pada Tabel 1, yang berbentuk cairan pada suhu kamar dan memiliki sifat unik, seperti tekanan uap diabaikan, tidak mudah terbakar, stabil pada suhu tinggi, reaktivitas kimia rendah, dan lain-lain (Bogdanov, et.al., 2009). Karena keunikannya bersama dengan fine-tunable density, viskositas, polaritas, dan miscibility dengan pelarut organik umumnya (Bogdanov, et.al., 2009) (Bogdanov, et.al., 2010), yang sangat aplikatif dalam berbagai bidang seperti sintesis (Hallett dan Welton, 2011), Katalisis (Parvulescu dan Hardacre, 2007), elektrokimia (Opallo dan Lesniewski, 2011), kimia analitik (Poole dan Poole, 2011), selain itu, bahan organik mudah terbakar (VOCs) yang berbahaya telah berhasil digantikan oleh RTILs dalam proses pemisahan (ektraksi) baik ekstraksi cair-cair maupun ekstraksi pada-cair (Ho, et.al., 2013).…”

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PENERAPAN IONIC LIQUID (ILs) SEBAGAI PELARUT ALTERNATIF UNTUK MENGEKSTRAKSI KOMPONEN AKTIF DARI TUMBUHAN OBAT: REVIEW

Ahmad¹,

Mun’im²

2016

Proceeding of the 3rd Mulawarman Pharmaceuticals Conferences

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ABSTRAKSelama dekade terakhir ionic liquids (ILs) merupakan pelarut alternatif baru dengan campuran (kation dan anion) memiliki sifat fisik dan sifat larutan yang spesifik dan telah terbukti sebagai substituen menjanjikan dari pelarut organik konvensional yang mudah terbakar, mudah menguap, dan beracun dalam berbagai proses. Dalam literatur dan penelitian, senyawa ini sering disebut pelarut ramah lingkungan. Namun, dalam beberapa tahun terakhir persepsi kehijauan berubah secara dramatis sebagai komunitas saintis yang mulai proaktif menilai resiko aplikasi bahan kimia berdasarkan pada seluruh siklus kehidupan. Aplikasi ILs dalam memisahkan komponen aktif dari tumbuhan obat dapat dilakukan dengan dibantu berbagai metode ekstraksi antara lain; heat refluks extraction (IL-HRE), microwave-assisted extraction (IL-MAE), ultrasound-assisted extraction (IL-UAE), IL-assisted ultrahigh pressure extraction (IL-UPE), supercritical fluid extraction (IL-SFE) dan negative-pressure cavitation-assisted extraction (IL-NPCE). Beberapa komponen aktif dari tumbuhan obat telah di ekstraksi menggunakan pelarut ionic liquid (ILs) antara lain; piperine, caffein, kuersetin, asam gallat, apigenin, stilbel, koumarin, flavanoid, ginsenosida (saponin), artemisin, dan lain-lain. Ulasan terkini memberikan gambaran komprehensif mengenai ILs sebagai pelarut alternatif dari pelarut organik konvensional untuk ekstraksi senyawa metabolit sekunder dari matriks tumbuhan obat. Faktor-faktor penting yang mempengaruhi efisiensi ekstraksi, toksisitas, dan mekanisme ekstraksi menggunakan ILs dengan penekanan khusus pada potensi dampak lingkungan dan secara inheren aman bagi peneliti. Kata Kunci : Ionic Liquids (ILs), metode ekstraksi, toksisitas, dampak lingkungan ABSTRACTOver past decade ionic liquids (ILs) is a new alternative solvent (contain cations and anions) have the physical and solution properties and had proven to be a promising substituent of conventional organic solvents are flammable, volatile and toxic in various processes. In the literature these compounds have often been referred to as environmentally friendly; however, in recent years the perception of their greenness dramatically changed as the scientific community began to proactively assess the risk of their application based on the entire life-cycle. Applications ILs in separating the active compound of the medicinal plants can be carried out using various extraction methods, such as heat refluks extraction (IL-HRE), microwave-assisted extraction (IL-MAE), ultrasound-assisted extraction (IL-UAE), IL-assisted ultrahigh pressure extraction (IL-UPE), and negative-

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Ecotoxicity analysis of cholinium-based ionic liquids to Vibrio fischeri marine bacteria

Cited by 197 publications

References 74 publications

Assessing the toxicity and biodegradability of deep eutectic solvents

Assessing the toxicity and biodegradability of deep eutectic solvents

Development of predictive QSAR models for Vibrio fischeri toxicity of ionic liquids and their true external and experimental validation tests

PENERAPAN IONIC LIQUID (ILs) SEBAGAI PELARUT ALTERNATIF UNTUK MENGEKSTRAKSI KOMPONEN AKTIF DARI TUMBUHAN OBAT: REVIEW

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