“…Acting unselectively on DNA, it has been hypothesized that anticancer drugs may harm all eukaryotic organisms by cytotoxic, genotoxic, mutagenic and carcinogenic effects (Johnson et al, 2008;Vyas et al, 2014). The biological risk posed by these anticancer molecules and their metabolites in aquatic species is not well elucidated (Mater et al, 2014), with few data on acute and chronic ecotoxicological assessments in algae Tetrahymena pyriformis (Bonnet et al, 2003), Pseudomonas putida (Zounková et al, 2007) and Pseudokirchneriella subcapitata (Zounková et al, 2007;Brezovsek et al, 2014;Česen et al, 2016); polychaete Nereis diversicolor (Fonseca et al, 2017); bivalve mollusc Mytilus galloprovincialis (Trombini et al, 2016); cladocera crustaceans Daphnia pulex (DellaGreca et al, 2007;Borgatta et al, 2015Borgatta et al, , 2016, D. magna (Zounková et al, 2007;Parrella et al, 2014aParrella et al, , 2014bParrella et al, , 2015 and Ceriodaphnia dubia (DellaGreca et al, 2007;Parrella et al, 2014aParrella et al, , 2014bParrella et al, , 2015; crustacean amphipod Ampelisca brevicornis (Moreira et al, 2016); and the fishes Danio rerio (Kovacs et al, 2015), Pimephales promelas (Winter et al, 2007) and Oryzias latipes (Sun et al, 2011). Limited information exists regarding Environmental risk assessment (ERA) for anticancer drugs.…”