Ecotoxicity of naproxen and its phototransformation products

Isidori, Marina; Lavorgna, Margherita; Nardelli, Angela; Parrella, Alfredo; Previtera, Lucio; Rubino, Maria

doi:10.1016/j.scitotenv.2004.12.068

Cited by 298 publications

(121 citation statements)

References 23 publications

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“…Acute toxicity tests performed on the rotifer Brachionus calyciflorus, the water flea Ceriodaphnia dubia and the fairy shrimp Thamnocephalus platyurus, showed that naproxen had LC50 4 and EC50 5 values within the 1-100 mg L −1 range, with the photolysis products being significantly more toxic [80]. Highly chronic toxic properties were equally noticed with algae being the less sensitive organisms.…”

Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

View full text Add to dashboard Cite

show abstract

“…However, the biggest disadvantage of these methods is generation of products with greater toxicity than the drug itself and formation of free radicals that directly damage biological structures [3][4][5][6]. The use of microorganisms in naproxen utilization brings many benefits.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Planococcus sp. S5 Strain on the Loofah Sponge and Its Application in Naproxen Removal

et al. 2018

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Planococcus sp. S5, a Gram-positive bacterium isolated from the activated sludge is known to degrade naproxen in the presence of an additional carbon source. Due to the possible toxicity of naproxen and intermediates of its degradation, the whole cells of S5 strain were immobilized onto loofah sponge. The immobilized cells degraded 6, 9, 12 or 15 mg/L of naproxen faster than the free cells. Planococcus sp. cells immobilized onto the loofah sponge were able to degrade naproxen efficiently for 55 days without significant damage and disintegration of the carrier. Analysis of the activity of enzymes involved in naproxen degradation showed that stabilization of S5 cells in exopolysaccharide (EPS) resulted in a significant increase of their activity. Changes in the structure of biofilm formed on the loofah sponge cubes during degradation of naproxen were observed. Developed biocatalyst system showed high resistance to naproxen and its intermediates and degraded higher concentrations of the drug in comparison to the free cells.

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“…platyurus were applied by Isidori et al (2005) to evaluate the ecotoxicity of naproxen and its photoproducts.…”

Section: Resultsmentioning

confidence: 99%

Short ingestion tests as alternative proposal for conventional range finding assays with Thamnocephalus platyurus and Brachionus calyciflorus

Jawecki

Szczesny

Solecka

et al. 2011

Int. J. Environ. Sci. Technol.

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ABSRACT:The goal of this study was to evaluate whether short 1 h sublethal assays may predict the results of 24 h lethality assays with rotifers Brachionus calyciflorus and anostracan crustaceans Thamnocephalus platyurus. The test bionts were hatched from cysts. Inhibition of ingestion was observed after 15 min of incubation of rotifers and crustaceans with the suspension of carmine and latex beads, respectively. Nine compounds with different modes of action were used as toxicants zinc ions, sodium dodecyl sulphate, p-nitrophenol, 3, 5-dichlorophenol and pharmaceuticals propranolol, fluoxetine, abamectin, doramectin and ivermectin. The toxicity values observed in the ingestion tests were very close to the mortality values over a wide range of toxicity from a low toxic surfactant to very toxic avermectins. The ratio between the 1 h EC 50 's in the ingestion test and the 24 h LC 50 's in the lethality test was below 2 in all cases for rotifers, and 7 in 9 cases for crustaceans. The toxicity of zinc and 3,5-dichlorophenol in the Thamnotoxkit F™ was 15-fold higher and 10 fold lower than in the ingestion test, respectively. The 24 h LC 50 values are within the range of 25-400 % of the 1 h EC 50 values for almost all toxicants tested with the exception of p-nitrophenol for B. calyciflorus and zinc and 3, 5-dichlorophenol for T. platyurus. Short, 1 h ingestion assays Rotoxrapid and Rapidtoxkit are good predictors of the mortality over the next 24 h and can be used as a range finding tests for representatives of pharmaceuticals and surfactants.

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Ecotoxicity of naproxen and its phototransformation products

Cited by 298 publications

References 23 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Immobilization of Planococcus sp. S5 Strain on the Loofah Sponge and Its Application in Naproxen Removal

Short ingestion tests as alternative proposal for conventional range finding assays with Thamnocephalus platyurus and Brachionus calyciflorus

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