Ecovio®-based nanofibers as a potential fast transdermal releaser of aceclofenac

Carvalho, Bruno Marques; Pellá, Michelly Cristina Galdioli; Hardt, Janice Caroline; Rossin, Ariane R. de S.; Tonet, Andressa; Ilipronti, Thiago; Caetano, Josiane; Dragunski, Douglas Cardoso

doi:10.1016/j.molliq.2020.115206

Cited by 19 publications

(9 citation statements)

References 59 publications

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“…This suggests that there is strong interaction between PBAT/PLA and lignin provided by secondary bonds such as hydrogen bonds, and formation of only one peak with higher intensity indicates that lignin improves compatibility between PBAT and PLA 44. In addition, the blends' OH bands areas were computed, Table1, presenting values lower than the corresponding 10wt% of lignin added into PBAT/PLA, suggesting intermolecular interaction between the carbonyls in PBAT/PLA and hydroxyls in lignin, which can be translated as strong indication of miscibility among the blends constituents, that is, PBAT/PLA/lignin.The band at 1455 cm À1 is attributed to the asymmetric and symmetrical elongation of CH 3 bonds in PBAT and PLA 45,46. The bands at 1087, 1165, and 1268 cm À1 indicate symmetrical elongation of C O bonds (ester and carboxylic acid) and asymmetrical elongation of C O C bonds found in PBAT and PLA, these bands also underwent alterations upon lignin addition, confirming the existence of interaction between PBAT/PLA/lignin by secondary hydrogen bonds.…”

mentioning

confidence: 67%

“…The band at 1455 cm À1 is attributed to the asymmetric and symmetrical elongation of CH 3 bonds in PBAT and PLA. 45,46 The bands at 1087, 1165, and 1268 cm À1 indicate symmetrical elongation of C O bonds (ester and carboxylic acid) and asymmetrical elongation of C O C bonds found in PBAT and PLA, these bands also underwent alterations upon lignin addition, confirming the existence of interaction between PBAT/PLA/lignin by secondary hydrogen bonds. The band at 939 cm À1 is attributed to the symmetrical elongation of C O bonds and the out-ofplane elongation attributed to the OH sites.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir) Measurementsmentioning

confidence: 77%

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Enhanced miscibility of PBAT/PLA/lignin upon γ‐irradiation and effects on the non‐isothermal crystallization

Barros

Soares

Moura

et al. 2022

J of Applied Polymer Sci

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Lignin is natural and renewable polymer, the second most abundant on Earth. Properly used it can reduce synthetic and oil based materials in addition to contributing to the biodegradable systems. In this work, the kraft lignin was subjected to gamma radiation at absorbed doses of 30, 60, and 90 KGy in order to increase the interaction with “Poly(butylene adipate‐co‐terephthalate) (PBAT)/Poly(lactic acid) (PLA)” blend (Ecovio®). PBAT/PLA/lignin blends with 10% of the weight of lignin were produced by extrusion using twin‐screw extruder and characterized by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), and Field emission scanning electron microscopy (FE‐SEM). FTIR spectra showed partial miscibility between PBAT/PLA and lignin, most due to the hydrogen bond between PBAT/PLA carbonyl and lignin hydroxyl, being intensified in irradiated lignin compounds. As evidenced on DSC scans, in PBAT/PLA/irradiated lignin the crystallization peak was shifted to lower temperatures and the crystallization rate decreased. Crystallization kinetics was modeled using Pseudo Avrami, and isoconversional models of Friedman and Vyazovkin. Pseudo‐Avrami displayed linearity deviation at beginning and crystallization ending due to the nucleation and secondary crystallization, while from Friedman and Vyazovkin the activation energy (Ea) was higher for PBAT/PLA/irradiated lignin 30 KGy, characterizing crystallization with higher energy consumption. FE‐SEM images showed better dispersion and miscibility in PBAT/PLA/irradiated lignin. The results indicate that the irradiation of Kraft lignin promotes miscibility and compatibility of PBAT/PLA/lignin.

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mentioning

confidence: 67%

Section: Fourier Transform Infrared Spectroscopy (Ftir) Measurementsmentioning

confidence: 77%

Enhanced miscibility of PBAT/PLA/lignin upon γ‐irradiation and effects on the non‐isothermal crystallization

Barros

Soares

Moura

et al. 2022

J of Applied Polymer Sci

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“…All samples showed typical PLA and PBAT transmittance bands. Characteristic FTIR transmittance bands of PBAT can be observed at 3400 cm −1 (hydroxyl stretching), 8 1714 cm −1 (C═O stretching from carbonyls and ester groups), 43–46 and at 1270 cm −1 (C─O stretching from ester groups) 45 . Phenyl rings from PBAT can also be observed at 1015 cm −1 , whereas the stretching of methylene groups could be assigned to the transmittance at 725 cm −1 43,45 …”

Section: Resultsmentioning

confidence: 99%

“…Typical PLA transmittance bands can be observed between 3500 and 3000 cm −1 (hydroxyl stretching) and between 3000 and 2850 cm −1 (CH 3 stretching). Bands between 2170 and 2100 cm −1 can be assigned to carboxyl O─H stretching 14,47 from PLA, whereas C─O bonds could be related to the transmittance band at 1750 cm −1 46,48 . The transmittance between 1300 and 1015 cm −1 can be attributed to PLA ester groups vibrations, 14,49 and at 700 cm −1 to methylene groups vibrations, which comprise a region close to PBAT (at 725 cm −1 ) 48 …”

Section: Resultsmentioning

confidence: 99%

PBAT/PLA/cellulose nanocrystals biocomposites compatibilized with polyethylene grafted maleic anhydride (PE‐g‐MA)

Nunes

Ribeiro

Martini

et al. 2021

J of Applied Polymer Sci

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The use of biodegradable polymers has grown exponentially due to their lower environmental impact when compared to conventional polymers. In this sense, biocomposites are an alternative due to their promising properties, maintaining biodegradability. For this purpose, in the present study, a biodegradable biocomposite of PBAT (poly [butylene adipate co‐terephthalate]) and PLA (polylactide) blend containing cellulose nanocrystals (CNC) were obtained, using polyethylene grafted with maleic anhydride (PE‐g‐MA) as a coupling agent. Seven formulations were produced by extrusion and had their structure, morphology, thermal, and rheological properties analyzed. The results showed a significant improvement of adhesion among the components using PE‐g‐MA as a coupling agent. Moreover, CNC and PE‐g‐MA increased the PLA crystallinity degree and reduced the complex viscosity. These results are unprecedented in the literature using these compositions and extrusion processing conditions. Therefore, these new insights provide a vast horizon for the use of biodegradable mixtures using PBAT/PLA and CNC.

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“…[22,23] Incorporating PBAT into PLA contributes to overcoming the limitations presented by PLA and allows the production of materials with improved mechanical and transport properties. [24,25] Polymer blends are recognized to reduce the undesired side effects of many drugs, particularly, those biological agents in which drug release is very important. [26] The polymeric blends may enhance drug loading and the use of the dispersed phase domains may improve drug release properties.…”

Section: Introductionmentioning

confidence: 99%

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

Liparoti,

Mottola,

De Marco

et al. 2023

Macro Materials & Eng

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Topical administration is the preferred route for the controlled release of active compounds since it reduces side effects typical of other administration methods. The use of polymer blends is a way to modulate drug release from a topical device. The blends ensure modulation of a wide range of properties, such as mechanical properties, water sorption, and degradation. This paper proposes blends of poly(lactide acid) (PLA), and Poly(butylene adipate‐co‐terephthalate) (PBAT), for the topical release of caffeine, a molecule with anti‐inflammatory, antioxidant, and anticellulite activities. PBAT/PLA blends are optimized for compatibility between the two polymers, mechanical properties, and drug release rate. Blends with a higher amount of PBAT show the best performance regarding polymer compatibility. The blends undergo supercritical CO2‐assisted caffeine impregnation. This process assures homogeneous dispersion of caffeine into the polymer matrix. The ratios 45/55 and 55/45 PBAT/PLA show the best performance in terms of caffeine release (complete caffeine release within 25 h). Caffeine is released into three steps: a burst effect due to the caffeine dispersed over the film surface, a slower release due to the caffeine dispersed in the polymer matrix, and a fast release due to the increase of polymer degradation rate induced by caffeine presence.

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Ecovio®-based nanofibers as a potential fast transdermal releaser of aceclofenac

Cited by 19 publications

References 59 publications

Enhanced miscibility of PBAT/PLA/lignin upon γ‐irradiation and effects on the non‐isothermal crystallization

Enhanced miscibility of PBAT/PLA/lignin upon γ‐irradiation and effects on the non‐isothermal crystallization

PBAT/PLA/cellulose nanocrystals biocomposites compatibilized with polyethylene grafted maleic anhydride (PE‐g‐MA)

PBAT/PLA Films and Supercritical Impregnation of Caffeine for Potential Application in Anticellulite Tools

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