Ecthyma gangrenosum-like eruption associated with<i>Morganella morganii</i>infection

Pozo, Del; GarcÍA-Silva,; Almagro,; Martínez, Vicente; [], Nicolas; Fonseca, Eduardo

doi:10.1046/j.1365-2133.1998.02423.x

Cited by 38 publications

(8 citation statements)

References 13 publications

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“…Ecthyma gangrenosum was traditionally considered a pathognomonic sign of sepsis caused by Pseudomonas 33,49,50 . However, numerous other organisms have subsequently been reported to cause clinically identical lesions 51–54 . We observed two patients in whom findings were consistent with the diagnosis of ecthyma gangrenosum, both of whom had Pseudomonas septicemia.…”

Section: Discussionmentioning

confidence: 59%

Acute bacterial septic vasculopathy

et al. 2012

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Nine of 32 patients were immunosuppressed. The foci of sepsis were variable; in 17 patients, the focus was not identified. Although Neisseria meningitidis was the most common causal agent, several microorganisms were identified. Cutaneous manifestations were an early event in 90.6% of patients. The most common skin signs were purpuric lesions and petechiae. Overall mortality was 28.1%; 65.5% of patients survived without sequelae. Skin biopsies showed thrombi in 100% of cases. Other common findings were inflammatory infiltrate, blood extravasation, and epidermal involvement. Bacteria within the vascular wall were seen in 21.9% of cases and fibrinoid necrosis in 25%. A comparison of ISPs with NISPs disclosed that meningococcemia was more common in the latter group, and the presence of pustules was more common in the former. Histopathology testing revealed that fibrinoid necrosis and bacterial invasion of the vessel wall were more common in ISPs than in NISPs. Conclusions Several microorganisms can cause septic vasculopathy. Clinical presentation is variable and does not depend on the microorganism or the pathogenic mechanism. Histopathologically, septic vasculopathy is a thrombo-occlusive vasculopathy with variable morphology. Cutaneous lesions are an early event and allow for rapid diagnosis.

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Section: Discussionmentioning

confidence: 59%

Acute bacterial septic vasculopathy

et al. 2012

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“…M. morganii bacteraemia is relatively uncommon but has a high rate of mortality. Urinary tract infection is probably the most common infection caused by M. morganii in humans, but the organism has also been documented as causing pneu- monia, empyema, wound infection, pericarditis, peritonitis, sepsis, arthropathy, endophthalmitis, meningitis, ecthyma gangrenosum-like eruptions and Fournier's gangrene (Bagel & Grossman, 1985;Cafferkey et al, 1988;Cunningham et al, 1997;Del Poso et al, 1998;Isobe et al, 1994;Mastroianni et al, 1994;Sica et al, 1995;García Reinoso et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Fatal Morganella morganii bacteraemia in a diabetic patient with gas gangrene

Ghosh

Bal

Malik

et al. 2009

Journal of Medical Microbiology

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We report a case of a 60-year-old lady with a history of a heel ulcer that had not responded to antibiotic therapy. This progressed to involve the right leg, which was swollen and erythematous. Radiological imaging revealed the presence of gas within the fascial planes. Blood cultures on admission yielded Morganella morganii. Due to the extent of the gas gangrene and her comorbidities the patient was not suitable for surgical intervention and was treated conservatively with antibiotics. She deteriorated and died within 72 h of presentation. Non-clostridial gas gangrene is relatively rare, and diagnosis is frequently delayed and often missed. Early aggressive surgical intervention combined with appropriate antibiotic therapy is essential. Bacterial species other than Clostridium should be considered in all cases of gas gangrene.

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“…Ecthyma gangrenosum is classically considered as a pathognomonic sign of sepsis by P. aeruginosa (7). Only 1.3–13% of patients with sepsis by P. aeruginosa develop cutaneous lesions (8). During septicemia the organism tends to multiply in the walls of small blood vessels, which results in arterial and venous thrombosis, and ultimately dermal necrosis (6).…”

Section: Discussionmentioning

confidence: 99%

Harlequin Baby with Ecthyma Gangrenosum

Güneş¹,

Akçakuş²,

Kurtoğlu³

et al. 2003

Pediatric Dermatology

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Pseudomonas aeruginosa bacteremia or sepsis often occurs in hospitals, affecting mainly children with underlying disease. Ecthyma gangrenosum is classically considered a pathognomonic sign of sepsis by P. aeruginosa. The harlequin baby, a severe variant of ichthyosis, occurs rarely, and these infants are at high risk of cutaneous infections and sepsis. We herein report a harlequin baby who developed ecthyma gangrenosum.

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Ecthyma gangrenosum-like eruption associated withMorganella morganiiinfection

Abstract: Ecthyma gangrenosum is considered as a pathognomonic sign of Pseudomonas aeruginosa sepsis. Lesions similar to ecthyma gangrenosum may be caused by other organisms. We report a case of an ecthyma gangrenosum-like eruption caused by Morganella morganii, a Gram-negative bacillus.

Cited by 38 publications

References 13 publications

Acute bacterial septic vasculopathy

Acute bacterial septic vasculopathy

Fatal Morganella morganii bacteraemia in a diabetic patient with gas gangrene

Harlequin Baby with Ecthyma Gangrenosum

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