Ectopia cordis, a successful single stage thoracoabdominal repair

Samir, Khaled; Ghez, Olivier; Métras, D; Kreitmann, Bernard

doi:10.1016/s1569-9293(03)00144-0

Cited by 15 publications

(10 citation statements)

References 2 publications

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“…11 Repair is often hindered by lack of sufficient tissue available for surgical reconstruction, particularly in the neonatal period. 37,39 In this scenario, tissue engineering approach appears as one of the most effective strategies to restore anatomic continuity and tissue integrity.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Hydroxyapatite-Functionalized PLLA Scaffold: Potential Applications in Sternal Bone Healing

et al. 2011

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Sternal synthesis after median sternotomy, a conventional access practice in thoracic and cardiac surgery, is at the basis of severe complications, often impairing the clinical outcome of surgical interventions. In this work, we propose the use of an acellular biomaterial scaffold, to be interposed across the fracture rime during closure operations, directly exposing the biomaterial to bone marrow, in order to expedite healing process. A rabbit model of median sternotomy was performed and an electrospun scaffold composed of a hydroxyapatite-loaded absorbable biopolymer (poly-L: -lactide), shaped into a fibrillar structure, was used. CT follow-up confirmed a complete healing in the scaffold-treated group 1 week before the control. Histological evaluation demonstrated presence of newly formed bone trabeculae among scaffold fibers showing a higher degree of maturity with respect to the control untreated group. The proposed approach is able to both guide a more rapid healing and modulate inflammatory response across the wound site, resulting in improved healing and tissue remodeling with respect to conventional closure technique.

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Section: Introductionmentioning

confidence: 99%

Electrospun Hydroxyapatite-Functionalized PLLA Scaffold: Potential Applications in Sternal Bone Healing

et al. 2011

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“…Repair is often hindered by lack of sufficient tissue available for surgical reconstruction, particularly in the neonatal period [2, 3]. Operative management of these conditions often involves at least two-stages: early soft-tissue coverage of the mediastinum and/or pleural cavity, followed by some form of a more definitive chest wall reconstruction up to a few years thereafter [4, 5].…”

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confidence: 99%

Sternal repair with bone grafts engineered from amniotic mesenchymal stem cells

Steigman

Ahmed

Shanti

et al. 2009

Journal of Pediatric Surgery

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Background We aimed at determining whether osseous grafts engineered from amniotic mesenchymal stem cells (aMSCs) could be employed in postnatal sternal repair. Methods Leporine aMSCs were isolated, identified, transfected with green fluorescent protein (GFP), expanded, and seeded onto biodegradable electrospun nanofibrous scaffolds (n=6). Constructs were dynamically maintained in an osteogenic medium and equally divided into two groups with respect to time in vitro, namely 14.6 or 33.9 weeks. They were then used to repair full thickness sternal defects spanning 2–3 intercostal spaces in allogeneic kits (n=6). Grafts were submitted to multiple analyses 2 months thereafter. Results Chest roentgenograms showed defect closure in all animals, confirmed at necropsy. Graft density as assessed by micro-CT scans increased significantly in vivo, yet there were no differences in mineralization by extracellular calcium measurements pre- and post-implantation. There was a borderline increase in alkaline phosphatase activity in vivo, suggesting ongoing graft remodeling. Histologically, implants contained GFP-positive cells and few mononuclear infiltrates. There were no differences between the two construct groups in any comparison. Conclusions Engineered osseous grafts derived from amniotic mesenchymal stem cells may become a viable alternative for sternal repair. The amniotic fluid can be a practical cell source for engineered chest wall reconstruction.

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“…Ectopia cordis is the congenital malpositioning of the heart to a position that is either fully or partially outside of the thoracic cavity . Many case reports exist in the human literature, and the reported prevalence in people is between 5.5 and 7.9 cases per 1 million live births . Recognized variations of the disorder include cervical, thoracocervical, thoracic, thoracoabdominal, and abdominal ectopia cordis .…”

Section: Discussionmentioning

confidence: 99%