Ectopic expression of cDNAs from larkspur (Consolida ajacis) for increased synthesis of gondoic acid (cis-11 eicosenoic acid) and its positional redistribution in seed triacylglycerol of Camelina sativa

Sarvas, Carlene; Puttick, Debbie; Forseille, Li; Smith, Mark

doi:10.1007/s00425-021-03682-5

Cited by 3 publications

(3 citation statements)

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“…(4 th ) (Cis 11-eicosenoic), (5 th ) (palmitic), as a chemical composition of propolis, has physico-chemical characteristics as well as DNA protective, cytotoxic, and antitumor activities (Andonova et al, 2023). (cis-11 eicosenoic acid) is considered the predominant verylong-chain fatty acid (Sarvas et al, 2021). Saturated fatty acids like palmitic acid (Tomata et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Propolis alleviated Cisplatin-induced hepatorenal oxidative stress and apoptosis

Adel Mohamed Mahmoud,

Salah,

Abd Elrhman

et al. 2024

Benha Veterinary Medical Journal

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The present research was planned to evaluate the protective effect of propolis water extract against cisplatin hepato-renal toxicity. Twenty-four male albino rats were divided into four equal groups. G1 (control) administered water only; G2 (propolis) administered (100 mg extract of propolis/kg body weight) orally by stomach tube at a once-daily dose for 14 days; G3 (cisplatin) administered once intraperitoneally (7.5 mg cisplatin/kg body weight) at day 10 of the experiment; and G4 (cisplatin+propolis) administered like G2 and G3. The serum biochemical analysis in the cisplatin group revealed an increase in AST, ALT, ALP, cholesterol, triglyceride, LDL-cholesterol, urea, and creatinine concentrations and a decrease in total protein and albumin concentrations. Moreover, cisplatin-treated rats significantly increased MDA levels and decreased SOD and CAT levels in hepatic and renal tissue compared to the control group. Administration of propolis (100 mg extract of propolis/kg.b.wt.) orally by stomach tube one hour before the second drug, which is once intraperitoneal (7.5 mg cisplatin/kg.b.wt.), at day 10 of the experiment (day number ten of the experiment, which continued for 14 days), reversed induced hepatorenal damage of the cisplatin group by exerting antioxidant and antiinflammatory effects. Histopathological and immuno-histochemical examinations showed the hepatorenal damage induced by cisplatin was attenuated by propolis. In conclusion, propolis may help to lessen the hepatorenal damage induced by cisplatin via its antioxidant and antiapoptotic activities.

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Section: Discussionmentioning

confidence: 99%

Propolis alleviated Cisplatin-induced hepatorenal oxidative stress and apoptosis

Adel Mohamed Mahmoud,

Salah,

Abd Elrhman

et al. 2024

Benha Veterinary Medical Journal

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“…Враховуючи дані таблиці, спостерігаємо значне зниження пальмітинової кислоти (С16:0) у всіх зразках відносно контрольного зразка (від 40,5 до 50,0%). Можемо припустити, що саме додавання продукції бджільництва зменшує вміст насичених жирних кислот, що є позитивним, оскільки насичені жирні кислоти пов'язують із підвищеним ризиком серцевосудинних захворювань, що також підтверджується дослідженнями (Sheshukova et al, 2021;Polianska et al, 2023). Відзначене зниження у всіх зразках пальмітолеїнової кислоти (С16:1), найбільше в зразку 2 (40,5%), це може вплинути на загальний вміст мононенасичених жирних кислот, зокрема, в залежності від їхньої ролі у підтримці рівня холестерину (Van Rooijen et al, 2021).…”

Section: Human and Nation's Health 2024unclassified

“…Зниження цієї важливої мононенасиченої жирної кислоти може бути негативним, оскільки олеїнова кислота сприяє зниженню рівня «поганого» холестерину (LDL) і підвищенню «хорошого» (HDL), як зазначають Gündüz et al ( 2024) та Lu et al (2024). Збільшення цис-11ейкозенової кислоти (С20:1n9) від 20,25% до 2,7 разів вказує на покращення вмісту мононенасичених жирних кислот, що має позитивний вплив на здоров'я, також підтведжується дослідженнями Sarvas et al (2021). Значне збільшення ліноленової кислоти (С18:3n3) від 2 до 2,8 разів свідчить про зростання вмісту омега-3 жирних кислот, що дуже позитивно, оскільки омега-3 жирні кислоти сприяють зниженню запальних процесів та покращенню серцевосудинного здоров'я.…”

Section: Human and Nation's Health 2024unclassified

Fatty acid composition of meat snacks with the addition of bee products

Antoniv

2024

humanhealth

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Determining the fatty acid composition of meat snacks with the addition of bee products is necessary to assess their nutritional value, as the content of different fatty acids affects the nutritional quality of the final product, which is important for consumer health. Improving the product's quality by reducing saturated fatty acids and increasing unsaturated ones, especially omega-3 and polyunsaturated fatty acids, makes meat snacks healthier for consumers and expands their use. A proper balance of fatty acids can help reduce the risk of cardiovascular diseases and inflammatory processes. Products with a better fatty acid profile may also be more appealing to health-conscious consumers. The aim of this study was to investigate the fatty acid composition of meat snacks with the addition of bee products according to various recipes. The determination was carried out using gas chromatography of methyl esters of fatty acids on a Trace Ultra gas chromatograph with a flame ionization detector, using a capillary column SP-2560 (Supelco). It was found that the addition of bee products to chicken meat snacks increased the omega-3 content by 2.6–3.3 times compared to the control and polyunsaturated fatty acids from 79.7% to 86%. The obtained results allow us to consider meat snacks with the addition of bee products as having a positive impact on health. The reduction in the omega-6 to omega-3 ratio from 10.2 in the control to 5.15–7.03 in the experimental samples proves the improvement in fatty acid balance, which may contribute to reducing inflammatory processes and improving overall health. A decrease in saturated fatty acids from 28.05% to 31.06% compared to the control has been proven, which is desirable for cardiovascular health. Slight positive changes in the content of monounsaturated fatty acids were observed. Overall, an improvement in the fatty acid composition of meat snacks with the addition of bee products (honey, water extract of propolis, bee pollen) was observed. The obtained research results will be useful when planning the production of meat snacks, considering the regulation of fatty acid composition, safety, and quality of the resulting products.

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Gondoic acid alleviates LPS‑induced Kupffer cells inflammation by inhibiting ROS production and PKCθ/ERK/STAT3 signaling pathway

Fan

Li²,

Liu³

et al. 2022

International Immunopharmacology

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Ectopic expression of cDNAs from larkspur (Consolida ajacis) for increased synthesis of gondoic acid (cis-11 eicosenoic acid) and its positional redistribution in seed triacylglycerol of Camelina sativa

Cited by 3 publications

References 93 publications

Propolis alleviated Cisplatin-induced hepatorenal oxidative stress and apoptosis

Propolis alleviated Cisplatin-induced hepatorenal oxidative stress and apoptosis

Fatty acid composition of meat snacks with the addition of bee products

Gondoic acid alleviates LPS‑induced Kupffer cells inflammation by inhibiting ROS production and PKCθ/ERK/STAT3 signaling pathway

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