Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds

Mirastschijski, Ursula; Impola, Ulla; Jahkola, Tiina; Karlsmark, Tonny; Ågren, Magnus S.; Saarialho–Kere, Ulpu

doi:10.1053/hupa.2002.32221

Cited by 89 publications

(95 citation statements)

References 29 publications

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“…It is unclear whether the increased VEGF-A expression during reepithelialization also stimulates the production of uPA and tPA by keratinocytes in an autocrine fashion (Schaffer and Nanney, 1996; Martin, 1997). Several matrix metalloproteinases, each of which cleaves a specific subset of matrix proteins, are also up-regulated by woundedge keratinocytes (Lohi et al, 2001;Mirastschijski et al, 2002;Saarialho-Kere et al, 2002). …”

Section: E Physiological Regulation Of Vascular Endothelial Growth Fmentioning

confidence: 99%

Vascular Endothelial Growth Factor and Angiogenesis

et al. 2004

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Section: E Physiological Regulation Of Vascular Endothelial Growth Fmentioning

confidence: 99%

Vascular Endothelial Growth Factor and Angiogenesis

et al. 2004

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“…66,2009 Review Article 211 the basement membrane zone and by complete resorption of provisional matrix from the wound bed. Both MMP-2 and MMP-9 are expressed in endothelial cells as well as are MT1-MMP and MMP-19 [95,96,128,129]. MMP-2 and MMP-9 have been shown to play pivotal roles in both physiologic and tumorigenic angiogenesis [130 -133].…”

Section: Mmps and Timpsmentioning

confidence: 99%

“…However, due to the chemical and physical changes in the cellular environment after skin injury, the expression of multiple MMPs is induced. MMPs that have been identified in normally healing skin wounds include collagenases MMP-1 and MMP-8 [93,94], gelatinases MMP-2 and MMP-9 [95], stromelysins MMP-3 and MMP-10 [77], metalloelastase MMP-12 [91], MT1-MMP [95], MMP-19 [96], MMP-26 [97] and MMP-28 [90]. The expression of TIMP-1, -2 and -3, but not TIMP-4, in acute skin wounds is also reported [98].…”

Section: Mmps and Timpsmentioning

confidence: 99%

“…MMP-2 and MMP-9, exhibit distinct expression pattern during cutaneous wound repair. MMP-9 is detected at the migrating epithelial front [84,91,95], whereas MMP-2 is exclusively expressed in the dermal compartment of skin by fibroblasts, especially adjacent to regenerating epidermis, and by endothelial cells in mouse excisional wounds and human partial-thickness acute wounds [91,95]. MMP-9 is also present in inflammatory cells including T cells and neutrophils [121,122].…”

Section: Mmps and Timpsmentioning

confidence: 99%

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Proteinases in cutaneous wound healing

Toriseva

Kähäri

2008

Cell. Mol. Life Sci.

174

145

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Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars.

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“…After skin injury, the proangiogenic factors FGF-1 and FGF-2 are released, while VEGF is induced by tissue hypoxia in the wound environment. In addition, the ECM proteins are degraded by proteolytic enzymes such as matrix metalloproteinases [26,27] that are released into the connective tissue. Other angiogenesis factors are released from specific collagen fragments, fibronectin, and elastin from recruited peripheral blood monocytes at the injured site, where they become activated macrophages.…”

Section: Phase 1: Pro-angiogenic Phase or Progressionmentioning

confidence: 99%

Panta Rhei: Neovascularization, Angiogenesis and Nutritive Perfusion in Wound Healing

et al. 2018

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Background: In response to tissue damage, angiogenesis is an extremely dynamic process that is finely regulated by signals from cells, the surrounding extracellular matrix (ECM), and derived mediators. As the only process, angiogenesis remains of decisive importance in the context of the entire wound healing process and is subject to constant change. The dissolution of the endothelial basement membrane, the migration of endothelial cells, and the development of new capillary vessels during wound healing depend not only on the cells and cytokines present, but also on the production and organization of ECM components in the immediate wound. Summary: Angiogenesis in wound healing can be divided into two main phases. During the pro-angiogenic phase at the beginning of wound healing, excessive neo-formation of blood vessels, some of which are poorly differentiated, occurs, which restore blood flow and thus nutritive perfusion as quickly as possible. This is followed by an anti-angiogenic phase in which the initially established vascular network undergoes a maturing process, which, however, is accompanied by a significant reduction in the number of vessels. Key Messages: Although many mechanisms and specific cell functions in wound healing have already been described, many underlying pathophysiological processes remain unknown. Because angiogenesis and its maturation is a very fast but also very long-lasting process, the understanding of the underlying mechanisms is of crucial importance. This article will give an overview of the current understanding and controversy in this sub-step of wound healing.

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Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds

Cited by 89 publications

References 29 publications

Vascular Endothelial Growth Factor and Angiogenesis

Vascular Endothelial Growth Factor and Angiogenesis

Proteinases in cutaneous wound healing

Panta Rhei: Neovascularization, Angiogenesis and Nutritive Perfusion in Wound Healing

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