Ectopic pregnancy and occupational exposure of hospital personnel

Bouyer, Jean; Saurel‐Cubizolles, Marie‐Josèphe; Grenier, Catherine; Aussel, Lucette; Job‐Spira, Nadine

doi:10.5271/sjweh.285

Cited by 12 publications

(12 citation statements)

References 23 publications

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“…Synonymous findings were also observed in a study conducted by Chudary et al 14 . The most common site of ectopic pregnancy was the fallopian tube in this study accounting for 96% of cases, which is almost same as Bouyer et al 15 (95.5%) and Smitha Singh et al 16 (96%). Ampullary part of the fallopian tube was the most common site reflected in 64% of the cases.…”

Section: Discussionsupporting

confidence: 83%

Experience with Ectopic Pregnancy in a Tertiary Care Teaching Hospital

Parveen

Sarker

2018

TAJ: J of Teachers Assoc

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Ectopic pregnancy is a common life-threating condition. Diagnosis is frequently missed and should be considered in any women in the reproductive age group presenting with abdominal pain or vaginal bleeding. This prospective observational study was conducted in RMCH to determine the incidence, risk factors, clinical presentation, treatment, morbidity and mortality associated with ectopic pregnancy. A total of 50 cases of ectopic pregnancy were operated during the study period giving the incidence of ectopic pregnancy of 8.02/1000 pregnancies. The age of the patient ranged from 18-37 years, with maximum (40%) between 26-30 years age group. 36% patients had delivered one child and 24% were nulliparous. 30% patients had pelvic inflammatory disease and 22% had history of previous abortion/ MR. All patients presented with lower abdominal pain, 68% presented with abnormal vaginal bleeding and 60% had amenorrhoea. Most of the patients were diagnosed by high clinical suspicion and confirmed by USG. 96% cases ectopic pregnancy occurred in the fallopian tube and ampullary part was mainly affected. Laparotomy followed by unilateral salphingectomy was performed in majority (60%) of cases. 22% cases ipsilateral salpingectomy with tubectomy other side and 12% cases salpingostomy were performed. The recovery of majority of patients was smooth and uneventful. There was no death in this study.TAJ 2014; 27(2): 22-26

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Section: Discussionsupporting

confidence: 83%

Experience with Ectopic Pregnancy in a Tertiary Care Teaching Hospital

Parveen

Sarker

2018

TAJ: J of Teachers Assoc

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“…All of the studies of stillbirths (or of fetal loss which combined miscarriage and stillbirth) had insufficient numbers of exposed cases (n = 1 to 13), resulting in wide confidence intervals 9,70,71,73,75,78,79 . We found only two studies of tubal pregnancies, both with ten or fewer exposed cases, and the results varied widely from OR=0.95 (95% CI 0.39–2.31) 80 to OR 11.4 (95% CI 2.7–17.6) 81 .…”

Section: Resultsmentioning

confidence: 88%

Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings

Connor

Lawson

Polovich

et al. 2014

Journal of Occupational &Amp; Environmental Medicine

147

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Objectives Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. Methods A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Results While effect sizes varied with study size and population, occupational exposure to antineoplastic drugs appears to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time-to-pregnancy also suggested an increased risk for sub-fertility. Conclusions Antineoplastic drugs are highly toxic in patients receiving treatment and adverse reproductive effects have been well documented in these patients. Healthcare workers with chronic, low level occupational exposure to these drugs also appear to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered.

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“…It has been suggested that EP is linked to chromosomal abnormalities (63,45) or exposure to antineoplastic drugs (64). Specific studies were conducted, which did not support these hypotheses (40,65,41). Hormonal factors have also been suspected (46) and immunological factors may be involved.…”

Section: Research Perspectivesmentioning

confidence: 99%

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

Bouyer

Coste²,

Shojaei³

et al. 2003

American Journal of Epidemiology

431

273

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This case-control study was associated with a regional register of ectopic pregnancy between 1993 and 2000 in France. It included 803 cases of ectopic pregnancy and 1,683 deliveries and was powerful enough to investigate all ectopic pregnancy risk factors. The main risk factors were infectious history (adjusted attributable risk = 0.33; adjusted odds ratio for previous pelvic infectious disease = 3.4, 95% percent confidence interval (CI): 2.4, 5.0) and smoking (adjusted attributable risk = 0.35; adjusted odds ratio = 3.9, 95% CI: 2.6, 5.9 for >20 cigarettes/day vs. women who had never smoked). The other risk factors were age (associated per se with a risk of ectopic pregnancy), prior spontaneous abortions, history of infertility, and previous use of an intrauterine device. Prior medical induced abortion was associated with a risk of ectopic pregnancy (adjusted odds ratio = 2.8, 95% CI: 1.1, 7.2); no such association was observed for surgical abortion (adjusted odds ratio = 1.1, 95% CI: 0.8, 1.6). The total attributable risk of all the factors investigated was 0.76. As close associations were found between ectopic pregnancy and infertility and between ectopic pregnancy and spontaneous abortion, further research into ectopic pregnancy should focus on risk factors common to these conditions. In terms of public health, increasing awareness of the effects of smoking may be useful for ectopic pregnancy prevention.

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Ectopic pregnancy and occupational exposure of hospital personnel

Cited by 12 publications

References 23 publications

Experience with Ectopic Pregnancy in a Tertiary Care Teaching Hospital

Experience with Ectopic Pregnancy in a Tertiary Care Teaching Hospital

Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

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