Ectopic production of salivary-type amylase by a lga-λ-type multiple myeloma

Hata, Hiroyuki; Matsuzaki, Hiromitsu; Tanaka, Kenji; Nomura, Hirotsune; Kagimoto, Tadashi; Takeya, Motohiro; Yamane, Nobuhisa; Takatsuki, Kiyoshi

doi:10.1002/1097-0142(19881015)62:8<1511::aid-cncr2820620811>3.0.co;2-l

Cited by 30 publications

(8 citation statements)

References 15 publications

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“…Amylase production or secretion by malignant plasma cells was described in a small number of cases and demonstrated by immunohistochemical techniques and tissue culture [8,11,12]. Structural alterations and rearrangements involving chromosome 1 near the amylase locus were observed [9,12,13] and it seems possible that the amylase gene might be activated by an oncogene [10].…”

Section: Discussionmentioning

confidence: 99%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

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This study reports a case of a patient with lambda-light chain multiple myeloma who developed a high hyperamylasaemia of the salivary type during the disease and soon afterwards died. Ectopic production of amylase by myeloma cells has been described in a few cases and demonstrated by tissue culture and immunohistochemical techniques. The common characteristics of these cases were: salivary amylase isoenzyme increase, high tumor mass, extensive extra-medullary spread, extensive bone destruction and poor prognosis. In patients with amylase-producing multiple myeloma, the onset of hyperamylasaemia heralds a rapid disease progression; therefore, in these patients, a simple test such as serum amylase may represent a reliable disease activity index and provide an additional prognostic information.

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Section: Discussionmentioning

confidence: 99%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

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“…[1][2][3][4][5][6] Recently, a few new clinical features associated with myeloma, such as salivary type hyperamylasemia [7][8][9][10][11][12][13] and elevation of the serum Creactive protein (CRP) concentration [14][15][16] and oncostatin M, 17 have been reported. Elevation of CRP is thought to be related to interleukin-6 (IL-6) production by myeloma cells, because of the identification of IL-6 as an autocrine and/or paracrine growth factor for myeloma cells.…”

Section: Introductionmentioning

confidence: 99%

In vitro excess ammonia production in human myeloma cell lines

et al. 1998

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It is well known that cases with multiple myeloma reveal various clinical manifestations such as pancytopenia, hyperproteinemia, renal dysfunction, bone lesions, hypercalcemia and immunodeficiency. Recently, a few more clinical features associated with myeloma, such as salivary type hyperamylasemia and elevated serum C-reactive protein (CRP) concentration, have been reported. The elevation of CRP is thought to be related to interleukin-6 (IL-6) production by myeloma cells, because of identification of IL-6 as an autocrine and/or paracrine growth factor for myeloma cells. More recently, there have been several reports of cases with myeloma associated with hyperammonemia. This hyperammonemia is not considered to be due to liver dysfunction, because in most of these cases tests revealed normal hepatic function, and some cases showed different patterns of serum amino acid distribution than that associated with hepatic failure. However, there have been no apparent observations of ammonia production by myeloma cells. In this study, we used six human myeloma cell lines including KMS-18, which was recently established from a myeloma case associated with hyperammonemia. These lines were treated with MRA (mycoplasma removal agent) to observe ammonia production in vitro. They produced and released significantly higher levels of ammonia into culture medium than non-myeloma hematological cell lines or the HepG2 human hepatic carcinoma cell line. Although attempts to analyze the relative expression levels of the enzymes related to ammonia biosynthesis using the reverse transcriptase-polymerase chain reaction assay failed to detect any differences between these myeloma lines and other cell lines, in vitro excess ammonia production by the myeloma cells was confirmed and the relevance to clinical manifestations is discussed.

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“…6 This patient had a A-IgA myeloma with extramedullary spread and died within 18 months of diagnosis. The amylase isoenzyme was the S type and this appears to be the more common isoenzyme associated with tumours.…”

Section: Discussionmentioning

confidence: 98%

“…Further evidence against macroamylasaemia was the normal urinary amylase/ Table 1. Amylase-producing myeloma -a review of cases reported in the literature Source Hata et al 6 Kanno et al 7 Proc. 30 th annual meeting Japanese Clinical Hematological SocietyB Wada et al 9 Tagawa et a/.…”

Section: Discussionmentioning

confidence: 99%

Hyperamylasaemia and Multiple Myeloma

2002

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This case report describes a 42-year-old Caucasian woman who presented with persistent hyperamylasaemia and no evidence of pancreatic pathology. Further investigations resulted in a diagnosis of light-chain multiple myeloma. Amylase production by epithelial tumours has been well documented but the association with multiple myeloma has only been described in a small number of cases. The link does not appear to be immunoglobulin class-specific but the association with Bence Jones myeloma is unusual. The common features in this group of patients have been extensive extramedullary spread with a high tumour mass and a poor prognosis. This case was similar in that the patient showed very rapid disease activity developing extensive metastatic lesions and treatment ultimately proved unsuccessful. The amylase concentrations have been shown to decrease in response to treatment and increase at times of relapse and it has been proposed that it may be useful as a tumour marker in these patients. This case study adds to the pool of patents with this unusual association.

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Ectopic production of salivary-type amylase by a lga-λ-type multiple myeloma

Cited by 30 publications

References 15 publications

Amylase: A disease activity index in multiple myeloma?

Amylase: A disease activity index in multiple myeloma?

In vitro excess ammonia production in human myeloma cell lines

Hyperamylasaemia and Multiple Myeloma

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