Ectopic Prostatic Tissue of the Anal Canal Presenting With Rectal Bleeding

Tekin, Koray; Sungurtekin, Uğur; Aytekin, Faruk Önder; Çallı, Neşe; Erdem, T. Ergün; Özden, Akın; Yalçin, Nagihan

doi:10.1007/s10350-004-6340-8

Cited by 21 publications

(11 citation statements)

References 7 publications

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“…Ectopic prostate tissue has previously been reported in the lower gastrointestinal tract such as anal canal. 4 , 7 However, this case is unique because it’s the first description of the presence of ectopic prostatic tissue in mural of the rectum. This is a highly unusual finding and probably reflects abnormal embryogenesis or divergent differentiation.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, it may be confused with malignancy in the gastrointestinal system, or retrovesical space. 3 , 4 Usually, surgical treatment by simple extirpation of the tumor is recommended and is curative. 9 There is possibility that ectopic prostatic tissue malignant transformation can happen 10 , however microscopic examination of the specimen in our case has not revealed any sign of malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Ectopic prostatic tissue is usually found incidentally but has also been a cause of lower gastrointestinal bleeding, obstructive symptoms, or a retroperitoneal mass. 2 - 4 Review of literature revealed variably sized lesions of ectopic prostate tissue involving a variety of organs outside the urinary tract, including pericolic fat, anal canal, uterine cervix, spleen, and seminal vesicle. 2 - 9 The ectopic location might be related to the abnormal embryogenesis or divergent differentiation of the prostate, rectum, and bladder.…”

Section: Introductionmentioning

confidence: 99%

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A novel submucosa nodule of the rectum: A case of the ectopic prostatic tissue outside the urinary tract

Dai¹,

Huang²,

Mao³

2013

Pak J Med Sci

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Ectopic prostatic tissue is an underreported entity, which is found most commonly in the lower male genitourinary tract, and ectopic prostate tissue outside the urinary tract is even rarer. Our patient was a unique case of ectopic prostatic tissue within submucosa of the rectum. The patient presented with rectal bleeding, and a firm, round solid submucosa nodule found in the anterior rectum at digital rectal examination, it was 1cm in diameter and 5cm above the anal verge. The size and submucosa location of this nodule were confirmed by the colonoscopy and MRI. After being removed surgically, the histopathology of the specimen sections possessed typical prostatic acini and stroma, meanwhile the immunohistochemical staining for prostate specific antigen confirmed its’ prostatic nature. It is the first case to date, which involves the mural of rectum. We hypothesizes that the etiologies of ectopic prostatic tissue within the submucosa rectum attribute to embryogenetic abnormality.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel submucosa nodule of the rectum: A case of the ectopic prostatic tissue outside the urinary tract

Dai¹,

Huang²,

Mao³

2013

Pak J Med Sci

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“…Because lesions of mammary glands and sweat glands stain for ER and GCDFP-15, immunohistochemistry may not be used to distinguish hidradenoma papilliferum from mammary lesions [8]. Phyllodes tumor has been found in ectopic prostate tissue, mostly in female patients, the most common locations being the vulva, vagina, cervix, urinary bladder and anal canal [11-13]. Gynecomastoid hyperplasia around the main lesion may cause a pathologist to suspect residual normal prostate glands.…”

Section: Discussionmentioning

confidence: 99%

Anal phyllodes tumor in a male patient: a unique case presentation and literature review

Tseng

et al. 2013

Diagn Pathol

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Lesions of anogenital mammary-like glands are rare, and only 44 female cases have been reported. Herein, we describe a particularly rare case of phyllodes tumor of anogenital mammary-like glands in a 41-year-old male presenting anal bleeding. Papillectomy was performed. The excised tumor was circumscribed in shape, and after it was sliced into sections, it was noted that there were leaf-like slits on the surface of cut side. Under the microscope, the tumor was found to be biphasic, with a bland glandular epithelium and low-to-intermediate cellular stroma, which together created the leaf-like slits. Gynecomastoid hyperplasia was evident at the periphery. The epithelium showed immuno-activity for ER, PR(focal), AR, and GCDFP-15. The stromal cells showed positive staining for CD34 and vimentin. The morphology and immunophenotype were similar to benign phyllodes tumors of breast. To the best of our knowledge, this case report represents the first case of phyllodes tumor of anogenital mammary-like glands with gynecomastoid hyperplasia at the periphery in a male patient. To make a diagnosis, we had to differentiate this lesion from hidradenoma papilliferum of skin appendage, phyllodes tumor of ectopic prostatic tissue, and other tumors of anogenital mammary-like glands analogous to the breast tumor (e.g., fibroadenoma phyllodes, periductal stromal sarcoma, and spindle cell carcinoma). While gynecomastia of male breast is usually a result of hormone imbalance, our patient’s tumor did not seem to be related to peripheral hormone status in the anogenital mammary-like glands. Nevertheless, because hormone imbalance has been strongly related to male breast cancer, hormone levels may need to be followed in male patients who have this rare malady.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1509145815899177

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“…At rectal examination, a 2.5-cm bleeding sessile polypoid mass was found in the anal canal and surgically removed. Pathologic evaluation confirmed the prostate as a source [15]. Another rare case of extra-urinary prostatic ectopia was described in a 64-year-old man presenting with dysuria secondary to an ectopic prostatic mass posterior to the bladder [16].…”

Section: Ectopic Prostatic Tissuementioning

confidence: 96%

Congenital prostatic abnormalities

Dean

2008

Curr prostate rep

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Congenital prostatic abnormalities are not commonly encountered in clinical practice but can provide insight into normal prostatic development. Furthermore, understanding normal prostate embryology and molecular signaling may provide novel approaches to the treatment of prostatic neoplasia. This review examines normal fetal development and congenital pathology of the prostate, including 5--reductase deficiency, prostatic ectopia, the prostate in the female pseudohermaphrodite, the prostate in prune belly syndrome, prostatic utricle, and trisomy syndromes.

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Ectopic Prostatic Tissue of the Anal Canal Presenting With Rectal Bleeding

Cited by 21 publications

References 7 publications

A novel submucosa nodule of the rectum: A case of the ectopic prostatic tissue outside the urinary tract

A novel submucosa nodule of the rectum: A case of the ectopic prostatic tissue outside the urinary tract

Anal phyllodes tumor in a male patient: a unique case presentation and literature review

Congenital prostatic abnormalities

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