Ectopic Thyroid-Stimulating Hormone–Secreting Pituitary Adenoma of the Nasopharynx Diagnosed by Gallium 68 DOTATATE Positron Emission Tomography/Computed Tomography

Kim, Stephanie; Dillon, William P.; Hope, Thomas A.; El‐Sayed, Ivan H.; Zante, Annemieke van; Wu, Karin; Masharani, Umesh

doi:10.1016/j.wneu.2019.02.022

Cited by 19 publications

(17 citation statements)

References 14 publications

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“…Articles were excluded if the cases were not ectopic TSH-oma or the diagnosis was not histologically confirmed. The results of searching PubMed yielded only 11 cases of ectopic TSH-oma (Table 1) (6,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Of all 12 patients, seven (58.33%) were females, and five (41.67%) were males, indicating a female predominance at a ratio of 1.4:1.…”

Section: Discussion Ectopic Tsh-omamentioning

confidence: 99%

“…Additional imaging examinations, such as positron emission tomography/ computed tomography (PET/CT) and PET/MRI, could contribute to the evaluation of the tumor location. 18 Ffluorodeoxyglucose (FDG) PET/CT is proposed to be positive in 60-67% of cases in studies involving pituitary adenomas (27,28), which can be meaningful for detecting adenomas, especially when the MRI findings are unclear. Ishizaki et al proposed that PET/CT revealed increased FDG uptake in EPA patients (4).…”

Section: Diagnosis Of Ectopic Tsh-oma In the Sellar Regionmentioning

confidence: 99%

“…Ishizaki et al proposed that PET/CT revealed increased FDG uptake in EPA patients (4). 68 Ga DOTAlabeled somatostatin analogs, such as 68 Ga DOTATATE, have been reported as somatostatin receptor imaging agents in PET/CT and PET/MRI to detect the presence of neuroendocrine tumors (18). Especially for well-differentiated neuroendocrine tumors, 68 Ga-DOTATATE PET has been proposed to have improved lesion detection compared with Octreoscan, 18 F-FDG PET/CT and PET/ MRI (29).…”

Section: Diagnosis Of Ectopic Tsh-oma In the Sellar Regionmentioning

confidence: 99%

“…68 Ga DOTAlabeled somatostatin analogs, such as 68 Ga DOTATATE, have been reported as somatostatin receptor imaging agents in PET/CT and PET/MRI to detect the presence of neuroendocrine tumors (18). Especially for well-differentiated neuroendocrine tumors, 68 Ga-DOTATATE PET has been proposed to have improved lesion detection compared with Octreoscan, 18 F-FDG PET/CT and PET/ MRI (29). Zhao et al confirmed different degrees of uptake of 68 Ga-DOTATATE and 18 F-FDG PET/CT in pituitary tissue and adenoma tissue, and the utilization of both would contribute to the differentiation of recurrent or residual pituitary adenoma and the remaining normal pituitary tissue after transsphenoidal tumor resection (30).…”

Section: Diagnosis Of Ectopic Tsh-oma In the Sellar Regionmentioning

confidence: 99%

“…Especially for well-differentiated neuroendocrine tumors, 68 Ga-DOTATATE PET has been proposed to have improved lesion detection compared with Octreoscan, 18 F-FDG PET/CT and PET/ MRI (29). Zhao et al confirmed different degrees of uptake of 68 Ga-DOTATATE and 18 F-FDG PET/CT in pituitary tissue and adenoma tissue, and the utilization of both would contribute to the differentiation of recurrent or residual pituitary adenoma and the remaining normal pituitary tissue after transsphenoidal tumor resection (30). Two markers revealed overlapping enhancement in the suprasellar region where the tumor was, which further supported the diagnosis of EPA (Figure 1).…”

Section: Diagnosis Of Ectopic Tsh-oma In the Sellar Regionmentioning

confidence: 99%

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Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region

Zhao

Hou

et al. 2021

Front. Endocrinol.

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Ectopic thyrotropin-secreting pituitary adenoma (ectopic TSH-oma) is a rare disorder that is easily misdiagnosed in clinical work. We report one patient who presented with hyperthyroidism and a suprasellar mass. In this case, preoperative diagnosis of suprasellar ectopic thyrotropin-secreting pituitary adenoma was challenging. A literature review revealed that a total of 11 patients with ectopic TSH-oma were previously reported, and only our one case was diagnosed in the microadenoma stage. Most of the patients with TSH-oma or ectopic TSH-oma were middle-aged. We described ectopic TSH-oma in a child at length. We recommend that ectopic TSH-oma should be considered in the differential diagnosis of thyrotoxicosis syndrome to achieve an accurate, early diagnosis. The somatostatin suppression test and imaging examinations, such as magnetic resonance imaging and positron emission tomography/magnetic resonance imaging, could contribute to the diagnosis. Once the diagnosis was highly suspected, tumor resection could achieve a satisfying long-term outcome in ectopic TSH-oma.

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