Ectopic Ventricular Tachycardia, Hypokalemia and Convulsions in Alcoholics

Scherf, David; Cohen, José E.; Shafiiha, H.

doi:10.1159/000169168

Cited by 28 publications

(4 citation statements)

References 11 publications

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“…In man, hypopotassemia increases the incidence of ectopic beats and rhythms and may produce ventricular fibrillation (24)(25)(26)(27). Our studies have shown that low K not only increases phase-4 depolarization but also increases the difference between the durations of the action potentials of the Purkinje and ventricular fibers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Low and High Concentrations of Potassium on the Simultaneously Recorded Purkinje and Ventricular Action Potentials of the Perfused Pig Moderator Band

Gettes

Surawicz

1968

Circulation Research

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The use of the perfused pig moderator band has allowed us to study the rapid simultaneous changes in Purkinje and ventricular action potentials induced by perfusing solutions of high (10 to 12 HIM) and low (0.6 to 0.8 HIM) K concentrations. High K shortened the plateau more in Purkinje fibers than in ventricular fibers and decreased the difference between the action potential durations of the two fiber types. Low K prolonged the plateau in Purkinje fibers but shortened it in ventricular fibers and increased the difference between the action potential durations. Low K initially hyperpolarized both Purkinje and ventricular fibers. However, the resting potential of the Purkinje fiber subsequently decreased as phase-4 depolarization increased. The decreased maximum repolarization potential associated with low K-induced pacemaker activity was time rather than voltage dependent. When the perfusate was changed from low K to control (K = 4.8 IIM), phase-4 depolarization was rapidly suppressed and the action potential of the Purkinje fiber was shortened to less than that produced by high K, and then changes in amplitude of the resting and action potentials occurred. Our observations help to explain some of the effects of low and high K on rhythm and conduction.ADDITIONAL KEY WORDS action potential plateau pacemaker resting potential maximum repolarization potential arrhythmia phase-4 depolarization Zwaardemaker-Librecht effect • Purkinje fibers have different electrophysiological properties than ventricular myocardial fibers (1-4). Spontaneous diastolic depolarization occurs normally in the Purkinje fibers but not in the ventricular fibers. In addition, the transmembrane action potentials of the Purkinje fibers have a greater amplitude, larger spike, more-.negative, restFrom the

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Section: Discussionmentioning

confidence: 99%

Effects of Low and High Concentrations of Potassium on the Simultaneously Recorded Purkinje and Ventricular Action Potentials of the Perfused Pig Moderator Band

Gettes

Surawicz

1968

Circulation Research

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“…13,14 To our knowledge no speci c serum level of ethanol in human s predisposes to increased risk of atrial arrhythmia in acute intoxication. The occurrence of paroxysmal supraventricular arrhythmia with ethanol is associated with electrolyte abnormalities, increaased catecholamine release, metabolic acidosis, increased oxidative stress and sleep apnoea.…”

Section: Discussionmentioning

confidence: 96%

Case study: Systemic complications following absolute alcohol embolisation of scalp arteriovenous malformation

Agrawal

Payal

Burathoki

et al. 2010

Southern African Journal of Anaesthesia and Analgesia

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Alcohol ablation is an accepted technique for the management of arteriovenous malformations. It is preferred due to the unique property of absolute alcohol to cause complete ablation and prevention of revascularisation. However, this technique is associated with multiple complications which may lead to patient morbidity. Here the case is presented of a female patient with scalp arteriovenous malformation who underwent alcohol ablation and developed supraventricular arrhythmia accompanied with haemodynamic instability and intravascular haemolysis in the postoperative period.

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“…Whether the increased risk of death outside hospital was due to alcohol as such or to related factors such as social maladjustment, or special personality, can not be determined at present. There are, however, studies suggesting that alcoholics have a predisposition for malignant arrhythmias (56,62). which may be further accentuated by myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Representative Male Survivors of Myocardial Infarction Compared with Representative Population Samples

Elmfeldt¹,

Wilhelmsson²,

Vedin³

et al. 1976

Journal of Internal Medicine

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A series of 299 men, aged 27-67, who had survived their first myocardial infarction (MI), have been compared with representative population samples with respect to tobacco consumption, alcoholic intemperance, physical activity during work and leisure time, Occurrence of hypertension, and cholesterol and triglyceride levels in serum. The infarction patients comprised 90% of all surviving, diagnosed cases of primary MI in men aged 67 years or below during 1%70 in Goteborg, Sweden. The comparison between infarction patients and general population samples revealed that the patients smoked more, and were less physically active during leisure time but not during work. They had more often a positive history of hypertension and treatment for high BP and their serum cholesterol and serum triglyceride values were higher. For all these variables the difference decreased with increasing age and was generally not statistically significant above the age of 60 years. Alcoholic intemperance was more common among infarction patients who died outside hospital, but there was no difference in this respect between surviving patients and the general population.When investigating characteristics which predispose for a certain disease, prospective studies are often most suitable. This method presupposes, however, that the disease has a relatively high incidence, as otherwise a sufficient number of patients cannot be collected within a reasonable time. A

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Ectopic Ventricular Tachycardia, Hypokalemia and Convulsions in Alcoholics

Cited by 28 publications

References 11 publications

Effects of Low and High Concentrations of Potassium on the Simultaneously Recorded Purkinje and Ventricular Action Potentials of the Perfused Pig Moderator Band

Effects of Low and High Concentrations of Potassium on the Simultaneously Recorded Purkinje and Ventricular Action Potentials of the Perfused Pig Moderator Band

Case study: Systemic complications following absolute alcohol embolisation of scalp arteriovenous malformation

Characteristics of Representative Male Survivors of Myocardial Infarction Compared with Representative Population Samples

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