Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa.

Sloper, K S; Brook, C. G. D.; Kingston, David G. I.; Pearson, J R; Shiner, Margot

doi:10.1136/adc.56.12.939

Cited by 43 publications

(15 citation statements)

References 7 publications

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“…These have included histological and functional abnormalities of the gastric epithelium,1 mild degrees of jejunal villous atrophy with eosinophil infiltration and oedema of the lamina propria,1 2 low jejunal mucosal IgA plasma cell counts,3 and increased IgE immunoreactive cells in the duodenal mucosa 4. There have also been a number of reports of increased gastrointestinal permeation by inert markers such as lactulose and rhamnose 5…”

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confidence: 99%

Gastrointestinal symptoms in atopic eczema

Caffarelli

Cavagni²,

Deriu³

et al. 1998

Archives of Disease in Childhood

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Aims-To determine the prevalence of gastrointestinal symptoms in children with eczema and the association of such symptoms with the extent of eczema or skin prick test results. Methods-Sixty five children with atopic eczema and a control group matched for age and sex were recruited. Their parents completed a questionnaire about the children's gastrointestinal symptoms. The children's skin was examined; their weight, height, and abdominal circumference were measured; and skin prick tests were carried out. Results-Gastrointestinal symptoms, especially diarrhoea, vomiting, and regurgitation, were more common in the children with eczema. Diarrhoea appeared to be associated with the ingestion of specific foods. Gastrointestinal symptoms were related to diVuse eczema and positive skin prick tests to foods. There was no anthropometric diVerences between the patient and control groups. Conclusions-A gastrointestinal disorder is common in children with eczema, especially with diVuse distribution. This may be responsible for substantial symptoms and may play a part in the pathogenesis of the disease and in the failure to thrive with which it is sometimes associated. (Arch Dis Child 1998;78:230-234)

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confidence: 99%

Gastrointestinal symptoms in atopic eczema

Caffarelli

Cavagni²,

Deriu³

et al. 1998

Archives of Disease in Childhood

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“…The respiratory and gastrointestinal tracts are the main affected organs [6,7,8]. IgA-deficient patients may be frequently affected by allergies, the most common of which is asthma followed by allergic rhinitis, conjunctivitis, urticaria, atopic dermatitis and food allergies [6,9]. Autoimmune diseases associated with SIGAD include immune thrombocytopenic purpura, autoimmune hemolytic anemia (AIHA), rheumatoid arthritis, lupus erythematosus, thyroiditis and vitiligo [10,11].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Switched Memory B Cells in Patients with IgA Deficiency

Aghamohammadi

Abolhassani

Biglari

et al. 2011

Int Arch Allergy Immunol

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Background: Selective IgA deficiency (SIGAD) is the most common primary antibody deficiency, characterized by significant decreased serum levels of IgA in the presence of normal IgG and IgM. Despite several investigations into the nature of the disease, the exact pathophysiology of SIGAD is still unknown. Methods: In this study, switched memory B cells (CD19+/CD27+/IgD– cell population) of 28 patients with SIGAD and 28 matched healthy controls were investigated using flow cytometry. Results: The percentage of switched memory B cells in all healthy controls was more than 0.4%. In SIGAD patients, who were classified as group I, the percentage of switched memory B cells was less than 0.4% (0.34 ± 0.06) in 7 patients (25%). The remaining 21 patients were designated as group II (1.74 ± 0.12%). The mean concentration of IgG in group I was significantly lower than in group II (1,014 ± 278 vs. 1,388 ± 406 mg/dl, p = 0.028). Comparison of clinical features between the 2 groups revealed that episodes of pneumonia during the course of disease were significantly higher in group I than in group II (p = 0.002). Autoimmune diseases in group I (57.1%) were also significantly higher (p = 0.01) than in group II (23.8%). The prevalence of bronchiectasis was 57% in group I, while only 1 patient (4.7%) in group II developed bronchiectasis (p = 0.006). Specific antibody deficiency in group I was documented in 5 patients and in group II in 4 patients (p = 0.01). Conclusions: The classification of SIGAD patients by assessment of switched memory B cells could help physicians with the clinical prognosis for these patients, whereas the patients with reduced switched memory B cells are prone to severe phenotypes.

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“…The reasons for this are unknown, but other immunological compensations might provide sufficient or complete restitution. IgA deficiency was found to be strongly associated with allergic diseases, including asthma, allergic rhinitis/conjunctivitis, urticaria, atopic dermatitis, and food allergies, [18][19][20][21][22]36 but the underlying mechanisms are not yet understood. It has been shown that the majority of these patients also have deficiency of secretory IgA.…”

Section: Discussionmentioning

confidence: 99%

“…1,5,7,[14][15][16][17] Immunoglobulin A (IgA) deficiency has been found to be associated with many allergies, including asthma, allergic rhinitis, urticaria, atopic dermatitis, and food allergies. [18][19][20][21][22] However, in the literature there are no studies about the prevalence of Ig deficiency in children with VKC. In this study, our aim was to determine the demographic characteristics, clinical features, prevalence of systemic atopy, and Ig deficiencies in Turkish patients with VKC.…”

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confidence: 99%