Edgeworthia gardneri (Wall.) Meisn. water extract improves diabetes and modulates gut microbiota

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

“…In this study, we observed significant differences in gut microbiota communities between the ND group and HFD group. At the phyla level, the gut of HFD-fed mice was characterized by increased abundance of Firmicutes and Proteobacteria, decreased abundance of Bacteroidales, as well as increased ratio of F/B, the profiling of which appeared similar to previously reported "obese gut" (Alard et al, 2016;Yu et al, 2018;Zhang et al, 2019b) and obesity-driven gut dysbiosis (Anhe et al, 2019;Jeong et al, 2019). In general, both Firmicutes and Bacteroidales are relevant with energy metabolism homeostasis (Ley et al, 2005).…”

“…Chinese herbal medicine has shown powerful capacity of improving both obesity and its metabolic diseases through the regulation of gut microbiota (Hasani-Ranjbar et al, 2009). Indeed, as gut microbiota composition is essential for the occurrence of obesity, varieties of bioactive substances from herb medicine were revealed to have positive impacts on gut microbiota and therefore could be used for the prevention or treatment of lipid metabolic disorders (Yu et al, 2018;Zhang et al, 2019b). For example, it is recently reported that the therapeutic effect of ganoderma lucidum against HFD-inducing obesity is actually working through the compositional regulation of gut microbiota (Chang et al, 2015;Chang et al, 2017).…”

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

“…For example, our findings were consistent with a study demonstrating that dietary chlorogenic acid increased Bacteroidaceae and their genus members Bacteroides in the gut microbiota of diet‐induced obese mice . Eucalyptus gardneri flower extract is high in coumarins (such as 4‐methylumbelliferone, psoralen, and scopoletin) and has also been shown to reverse the changes in the abundance of Clostridiales, Lachnospiraceae, Rikenellaceae, and Ruminococcus in diabetic mice . Finally, short‐chain fatty acids (SCFAs), produced by intestinal anaerobic microbial fermentation of indigestible carbohydrates (dietary fibers and polysaccharides), may alter the gastrointestinal pH and environment to influence gut microbiota composition .…”

“…In addition, flavonoids, coumarins, and phenolic acids in A. keiskei also have anti‐obesity effects . The ability of phytochemical‐rich foods to prevent obesity and metabolic diseases via gut microbiota modulation has been extensively reported . However, the role of the whole A. keiskei plant in the prevention of obesity or its relationship with intestinal microbiota composition changes is still unclear.…”

Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes

“…Meisn (Lv Luo Hua in Chinese) has been used to prepare an herbal tea that is commonly consumed as a healthy beverage in Tibet to ameliorate the metabolic disorders (Xu et al, 2012;Zhang et al, 2019b). It has reported that the extracts of the flower of E. gardneri has a wide array of pharmacological activities, such as anti-hyperglycemia, anti-adipogenesis, and aglucosidase inhibition (Ma et al, 2015;Gao et al, 2016;Zhang et al, 2019b). However, scant reports have been issued on the anti-IR property of the water extract of flower of E. gardneri (WEE) and the underlying mechanism of this action remains unclear.…”