Edible Vaccines in Plants for Livestock Pathogens

Erickson, L.; Yu, W-J.; Tuboly, Tamás; Nagy, Éva; Bailey, Ana M.; Zhang, J.; Yoo, Dongwan; Du, Sarah

doi:10.1007/978-94-017-2317-6_15

Cited by 1 publication

(1 citation statement)

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“…The latter plant is used as a possible source of livestock feed in developing countries. Included among livestock-related antigens expressed in alfalfa are those from foot and mouth disease, TGEV, classical swine fever virus and Mannheimia haemolytica (Wigdorovitz et al, 1999;Erickson et al, 2002;Ziauddin et al, 2004;Legocki et al, 2005). An alfalfa expression system is the basis of the commercial enterprise Medicago, Inc., which has developed alfalfa transformation and protein production strategies to make it an attractive alternative to more common platforms (D'Aoust et al, 2002).…”

Section: Methodologies For Expression Of Vaccine Antigens In Planta Ementioning

confidence: 99%

Plant-made vaccines: biotechnology and immunology in animal health

Rice¹,

Ainley²,

Shewen

2005

Anim. Health. Res. Rev.

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The use of plants as production systems for vaccine antigens has been actively investigated over the last 15 years. The original research focused on the value of this expression system for oral delivery based on the hypothesis that plant-expressed antigens would be more stable within the digestive tract and would allow for the use of the oral route of administration to stimulate a mucosal immune response. However, while first conceived for utility via the oral route, plant-made antigens have also been studied as classical immunogens delivered via a needle to model animal systems. Antigens have been expressed in a number of whole plant and cell culture systems. Several alternative expression platforms have been developed to increase expression of antigens or to elicit preferred immunological responses. The biotechnological advances in plant expression and the immunological testing of these antigens will be reviewed in this paper focusing primarily on diseases of livestock and companion animals.

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