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Wallin, Diana; Tkáč, Ivan; Stucker, Sara; Ennis, Kathleen; Sola‐Visner, Martha; Rao, Raghavendra; Georgieff, Michael

doi:10.1038/pr.2015.79

Cited by 1 publication

(1 citation statement)

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“…The 4-week striatum and cortex data that were available from a limited number of animals were insufficient to draw definitive conclusions about the presence or absence of sex differences at 1 month. To provide some insight into the question whether the neurochemical differences are present from birth or ensue after puberty, we investigated hippocampus data available from P14 (2-week-old) mice collected in another study (Wallin et al, 2015) and observed no differences in any metabolite levels between males and females (data not shown). These data were not included in our analysis because the neurochemical profile in the developing mouse brain is very different from the adult brain.…”

Section: Age-sex Interactions In Neurochemical Levelsmentioning

confidence: 99%

Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla

Tkáč,

Xie,

Shah

et al. 2023

Front. Neurosci.

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ObjectiveTo determine sex differences in the neurochemical concentrations measured by in vivo proton magnetic resonance spectroscopy (1H MRS) of healthy mice on a genetic background commonly used for neurodegenerative disease models.Methods1H MRS data collected from wild type mice with C57BL/6 or related genetic backgrounds in seven prior studies were used in this retrospective analysis. To be included, data had to be collected at 9.4 tesla magnetic field using advanced 1H MRS protocols, with isoflurane anesthesia and similar animal handling protocols, and a similar number of datasets from male and female mice had to be available for the brain regions analyzed. Overall, 155 spectra from female mice and 166 spectra from male mice (321 in total), collected from six brain regions (brainstem, cerebellum, cortex, hippocampus, hypothalamus, and striatum) at various ages were included.ResultsConcentrations of taurine, total creatine (creatine + phosphocreatine), ascorbate, glucose and glutamate were consistently higher in male vs. female mice in most brain regions. Striatum was an exception with similar total creatine in male and female mice. The sex difference pattern in the hypothalamus was notably different from other regions. Interaction between sex and age was significant for total creatine and taurine in the cerebellum and hippocampus.ConclusionSex differences in regional neurochemical levels are small but significant and age-dependent, with consistent male–female differences across most brain regions. The neuroendocrine region hypothalamus displays a different pattern of sex differences in neurochemical levels. Differences in energy metabolism and cellular density may underlie the differences, with higher metabolic rates in females and higher osmoregulatory and antioxidant capacity in males.

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Section: Age-sex Interactions In Neurochemical Levelsmentioning

confidence: 99%