Editorial: impact of the introduction of direct‐acting anti‐viral drugs on hepatocarcinogenesis—a prospective serial follow‐up MRI study

Abstract

LINKED CONTENT This article is linked to the Kumada et al and Kumada papers. To view these articles, visit https://doi.org/10.1111/apt.15825 and https://doi.org/10.1111/apt.15939

Editorial: impact of the introduction of direct‐acting antiviral drugs on hepatocarcinogenesis—a prospective serial follow‐up MRI study. Author’s reply

“…I thank Dr Ito for his comments on our recent publication 1,2 . I generally agree with the points discussed in his editorial.…”

“…I generally agree with the points discussed in his editorial. In this study, we showed that sustained virological response (SVR) by direct‐acting antiviral (DAA) drugs reduced the incidence of hypervascularisation of nonhypervascular hypointense nodules (NHHNs) observed during the hepatobiliary phase (HBP) of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid‐enhanced magnetic resonance imaging (Gd‐EOB‐MRI) 1 . However, the mechanisms remain unclear regarding the suppression of hypervascularisation of NHHNs during the transition from dysplastic nodules (DN), especially high‐grade DN, or early hepatocellular carcinoma (HCC) to advanced HCC.…”