Editorial: impact of the introduction of direct‐acting antiviral drugs on hepatocarcinogenesis—a prospective serial follow‐up MRI study. Author’s reply

Abstract

LINKED CONTENT This article is linked to Kumada et al and Ito papers. To view these articles, visit https://doi.org/10.1111/apt.15825 and https://doi.org/10.1111/apt.15911

Editorial: impact of the introduction of direct‐acting anti‐viral drugs on hepatocarcinogenesis—a prospective serial follow‐up MRI study

“…In 719 patients with HCV who were included in this study, multistep and de novo hepatocarcinogenesis occurred in 58 (86.6%) and nine patients (13.4%), respectively, during the follow‐up period. The eradication of HCV by DAAs was found to dramatically reduce the risk of multistep hepatocarcinogenesis after adjustment for the imbalance in HCC risks between the DAA and non‐DAA groups by inverse probability weighting to the Kaplan‐Meier method 5 . Kumada et al previously discussed nonhypervascular hypointense nodules (NHHNs), defined as hypo‐intense nodules that are detected in the hepatobiliary phase and that show no enhancement by Gd‐EOB‐MRI in the arterial phase; the authors reported that the incidence rates of hypervascularity in NHHNs were 27.6% and 43.5% at 6 and 12 months, respectively 6 .…”