Editorial Molecular imaging of stem cell therapy in brain tumors: a step towards personalized medicine

Sandu, Nora; Schaller, Bernhard

doi:10.5114/aoms.2012.30282

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…The new perspective of usage in cancer treatment of platinum nanoparticles programmed to activate the cell death pathways are promising for patients diagnosed with cancer diseases. However, without the proper diagnostic tools, including innovative molecular imaging of brain tumor, the treatment strategy may be inefficient [ 31 , 32 ]. Molecular evaluation of gliomas can also maximize treatment efficacy, decrease the gap between the primary in vitro and preclinical in vivo research, and can help to improve the anticancer properties of molecules against selected types of cells [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme

Kutwin¹,

Sawosz²,

Jaworski³

et al. 2017

aoms

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IntroductionGliomas are the most aggressive and common primary tumors of the central nervous system (CNS). Many side effects of drugs containing platinum and their poor penetration of the CNS are major drawbacks in glioma therapy. The aim of the study was to investigate and compare the toxicity of platinum nanoparticles and cisplatin and their anticancer properties in examination with a U87 glioma cell line and tumor.Material and methodsNanoparticles of platinum (NP-Pt) and cisplatin were incubated with U87 glioma cells or injected directly into tumor tissue. The biological properties of NP-Pt and cisplatin were compared through the morphology, viability, mortality, genotoxicity and the type of cell death of U87 glioma cells, the morphology and ultrastructure of glioma tumor, and expression of caspase-3, p53 and PCNA mRNA.ResultsNP-Pt at concentrations of 0.14 µM/ml, 0.29 µM/ml and 0.65 µM/ml had a harmful influence on viability of U87 glioblastoma multiforme (GBM) cells, but also showed genotoxic properties as well as a pro-apoptotic effect on cancer cells. It was found that NP-Pt decreased the weight and volume of U87 GBM tumor tissue and caused pathomorphological changes in the ultrastructure and morphology of tumor tissue, but they also upregulated p53 and caspase-3 mRNA expression.ConclusionsThe comparison between the effectiveness of glioblastoma treatment by NP-Pt vs cisplatin showed promising results for future studies. The results indicate that the properties of NP-Pt might be utilized for brain cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme

Kutwin¹,

Sawosz²,

Jaworski³

et al. 2017

aoms

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“…Molecular imaging (MI) can detect functional changes at the cellular level and possesses the ability to detect diseases at an early stage . In the field of oncology, MI not only detects cancer at an early stage but also aids in the staging of cancer and therapeutic response . For example, MI holds the potential of detecting cancer lesions less than 0.5 cm 3 in volume.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, detection of disease at its embryonic stage provides a much greater potential for complete recovery. The assistance MI provides toward understanding the molecular changes within the region of interest in body helps physicians develop a highly patient‐specific treatment regimen (personalized therapy) . In fact, highly sensitive molecular imaging agents are being developed at a rapid pace to identify the abnormalities within human body .…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles for molecular imaging

Srikar

Upendran

Kannan

2014

WIREs Nanomed Nanobiotechnol

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Conventional imaging technologies (X-ray computed tomography, magnetic resonance, and optical) depend on contrast agents to visualize a target site or organ of interest. The imaging agents currently used in clinics for diagnosis suffer from disadvantages including poor target specificity and in vivo instability. Consequently, delivery of low concentrations of contrast agents to region of interest affects image quality. Therefore, it is important to selectively deliver high payload of contrast agent to obtain clinically useful images. Nanoparticles offer multifunctional capabilities to transport high concentrations of imaging probes selectively to diseased site inside the body. Polymeric nanoparticles, incorporated with contrast agents, have shown significant benefits in molecular imaging applications. These materials possess the ability to encapsulate different contrast agents within a single matrix enabling multimodal imaging possibilities. The materials can be surface conjugated to target-specific biomolecules for controlling the navigation under in vivo conditions. The versatility of this class of nanomaterials makes them an attractive platform for developing highly sensitive molecular imaging agents. The research community's progress in the area of synthesis of polymeric nanomaterials and their in vivo imaging applications has been noteworthy, but it is still in the pioneer stage of development. The challenges ahead should focus on the design and fabrication of these materials including burst release of contrasts agents, solubility, and stability issues of polymeric nanomaterials.

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Molecular imaging for stem cell therapy in the brain

2015

Self Cite

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Molecular imaging is one of the methods to follow-up stem cell therapy by visualization in the brain. In a recent article in Stem Cell Research & Therapy, Micci et al. offer a thorough discussion of the advantages and disadvantages of this method and their roles in the future. The authors are among the very first who have implemented recently introduced molecular imaging techniques in experimental research and clinical practice.

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Editorial Molecular imaging of stem cell therapy in brain tumors: a step towards personalized medicine

Cited by 3 publications

References 41 publications

Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme

Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme

Polymeric nanoparticles for molecular imaging

Molecular imaging for stem cell therapy in the brain

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