Editorial: New Insights into Estrogen/Estrogen Receptor Effects in the Cardiac and Skeletal Muscle

Lowe, Dawn A.; Kararigas, Georgios

doi:10.3389/fendo.2020.00141

Cited by 12 publications

(11 citation statements)

References 25 publications

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“…While estrogen deficiency was previously shown to affect muscle mass and function 21 , it is unclear how perturbed estrogen-estrogen receptor signaling specific to muscle can alter myokine expression and which myokines are affected. As we had measured changes to osteoclast differentiation and activity with the addition of conditioned media from muscle lacking estrogen receptors (ERα-cKO animals) as well as animals deficient in estrogen (Figs.…”

Section: Resultsmentioning

confidence: 99%

Estrogen regulation of myokines that enhance osteoclast differentiation and activity

Norton

Thieu

Baumann

et al. 2022

Sci Rep

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Osteoporosis and sarcopenia are maladies of aging that negatively affect more women than men. In recent years, it has become apparent that bone and muscle are coupled not only mechanically as muscle pulls on bone, but also at a higher level with myokines, biochemical and molecular signaling occurring between cells of the two tissues. However, how estrogen deficiency in females impacts the chemical crosstalk between bone and muscle cells is not understood. We hypothesize that changes in estrogen signaling alters myokine expression and intensifies bone loss in women. In our present study, we demonstrate that conditioned media from ovariectomized or skeletal muscle deficient in estrogen receptor α (ERα) expression enhances osteoclast differentiation and activity. Using a cytokine array, we identified myokines that have altered expressions in response to loss of estrogen signaling in muscle. Lastly, we demonstrate that conditional deletion of ERα in skeletal muscle results in osteopenia due to an increase in the osteoclast surface per bone surface. Our results suggest that estrogen signaling modulates expression of myokines that regulate osteoclast differentiation and activity.

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Section: Resultsmentioning

confidence: 99%

Estrogen regulation of myokines that enhance osteoclast differentiation and activity

Norton

Thieu

Baumann

et al. 2022

Sci Rep

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“…(2) We used only male mice. Accumulating evidence has suggested that estrogen plays an important role in the muscle function [ 61 ]. Importantly, loss of estrogenic function contributes to alter muscle function and increases the risk of various chronic diseases including sarcopenia, type 2 diabetes, metabolic syndrome, and cardiovascular disease [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Otsuka

Yokomizo

Nakamura

et al. 2022

Biochemical Journal

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There has been a concern that sodium-glucose cotransporter 2 (SGLT2) inhibitors could reduce skeletal muscle mass and function. Here, we examine the effect of canagliflozin (CANA), an SGLT2 inhibitor, on slow and fast muscles from nondiabetic C57BL/6J mice. In this study, mice were fed with or without CANA under ad libitum feeding, and then evaluated for metabolic valuables as well as slow and fast muscle mass and function. We also examined the effect of CANA on gene expressions and metabolites in slow and fast muscles. During SGLT2 inhibition, fast muscle function is increased, as accompanied by increased food intake, whereas slow muscle function is unaffected, although slow and fast muscle mass is maintained. When the amount of food in CANA-treated mice is adjusted to that in vehicle-treated mice, fast muscle mass and function are reduced, but slow muscle was unaffected during SGLT2 inhibition. In metabolome analysis, glycolytic metabolites and ATP are increased in fast muscle, whereas glycolytic metabolites are reduced but ATP is maintained in slow muscle during SGLT2 inhibition. Amino acids and free fatty acids are increased in slow muscle, but unchanged in fast muscle during SGLT2 inhibition. The metabolic effects on slow and fast muscles are exaggerated when food intake is restricted. This study demonstrates the differential effects of an SGLT2 inhibitor on slow and fast muscles independent of impaired glucose metabolism, thereby providing new insights into how they should be used in patients with diabetes, who are at a high risk of sarcopenia.

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“…In addition to sex chromosomes and (epi)genetic factors [1,7,8,15], steroid hormones are expected to be one of the main factors that drive differences between the sexes. In particular, 17β-oestradiol (E2) and its receptors (ER) are thought to play a major role [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Oestrogenic Regulation of Mitochondrial Dynamics

Kalkhoran

Kararigas

2022

IJMS

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Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion–fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems.

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Editorial: New Insights into Estrogen/Estrogen Receptor Effects in the Cardiac and Skeletal Muscle

Cited by 12 publications

References 25 publications

Estrogen regulation of myokines that enhance osteoclast differentiation and activity

Estrogen regulation of myokines that enhance osteoclast differentiation and activity

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

Oestrogenic Regulation of Mitochondrial Dynamics

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