Editorial: putting more muscle into treating our chronic hepatitis B patients—the importance of assessing sarcopenia

Mudaliar, Sanjivan; Liu, Ken

doi:10.1111/apt.14894

Cited by 3 publications

(3 citation statements)

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“…We thank Drs Tian and Ngu for their insightful comments on our study, and we would like to make some further observations 1,2 . We agree that skeletal muscle loss is significantly related to adverse clinical outcomes among patients with chronic liver disease in terms of morbidity and mortality 3 . More recently, a meta‐analysis showed that the overall prevalence of sarcopenia among patients with cirrhosis is approximately 40.0% 4 .…”

supporting

confidence: 52%

“…1,2 We agree that skeletal muscle loss is significantly related to adverse clinical outcomes among patients with chronic liver disease in terms of morbidity and mortality. 3 More recently, a meta-analysis showed that the overall prevalence of sarcopenia among patients with cirrhosis is approximately 40.0%. 4 Furthermore, a decrease of 3.0% and 12.0% supported by Fundação de Amparo à Pesquisa do Estado de Minas Gerais (grant APQ-02320-18).…”

mentioning

confidence: 99%

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Editorial: Hepatitis C virus eradication improves skeletal muscle mass—Authors' reply

Coelho,

de Vries,

Pires

et al. 2024

Aliment Pharmacol Ther

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confidence: 52%

mentioning

confidence: 99%

Editorial: Hepatitis C virus eradication improves skeletal muscle mass—Authors' reply

Coelho,

de Vries,

Pires

et al. 2024

Aliment Pharmacol Ther

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“…Computed tomography (CT) scan can be used to assess the skeletal muscle mass and to identify sarcopenia based on sex‐specific cutoff points for “low” values . In addition, this approach has been regarded as the gold standard to define sarcopenia in recent studies, since it is routinely available for diagnosis and follow‐up in many patients as part of standard care, and it provides an opportunity to noninvasively and precisely quantify skeletal muscle …”

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confidence: 99%

Influence of Methods Used to Establish Sarcopenia Cutoff Values for Skeletal Muscle Measures Using Unenhanced and Contrast‐Enhanced Computed Tomography Images

Feng

Rong

Luo

et al. 2019

J Parenter Enteral Nutr

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Background:Multiple cutoff values of computed tomography (CT)-based skeletal muscle measures have been proposed, but there is currently no consensus used to identify sarcopenia. We aimed to evaluate the influence of statistical methods used to establish sarcopenia cutoff values and to examine the impact of contrast enhancement on the skeletal muscle measures. Methods: The skeletal muscle area (SMA) and muscle radiation attenuation (MRA) of 316 healthy individuals were measured on unenhanced CT images at the third lumbar vertebra level, and the skeletal muscle index (SMI) was SMA divided by height squared. Possible cutoff values were established using 2 methods: 5 th percentile of individuals aged 20-60 years or mean − 2 × SD of individuals aged 20-50 years. The concordance was assessed using Cohen's κ coefficients and McNemar test. The skeletal muscle parameters on 3 phases from 30 CT examinations were compared. Results: The concordance between the 2 methods was almost perfect (κ coefficients: 0.830-0.849) for low MRA but slight to moderate (κ coefficients: 0.189-0.591) for low SMI, especially in the men (P < 0.01). Compared with the unenhanced images, the mean SMA, SMI, and MRA on the contrast-enhanced images increased by 0.8%-1.7%, 0.8%-1.8%, and 14.8%-21.6% (all P < 0.001), respectively, and only the changes in MRA were clinically significant. Conclusions: The methods for establishing cutoff values and contrast enhancement influence the identification of low SMI and low MRA, respectively. Thus, the definition of sarcopenia should include the standardized method for establishing cutoff values and the phase of CT for analysis. (JPEN J Parenter Enteral Nutr. In this study, we comprehensively evaluated the influence of statistical methods used to establish sarcopenia cutoff values in a healthy population and examined the impact of contrast enhancement on the skeletal muscle measures. Our study highlights the standardized method for establishing cutoff values and the phase of computed tomography for analysis in the definition of sarcopenia. Future research should further validate the proposed sex-specific cutoff values in different patient populations.From the

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Sarcopenia in chronic liver diseases: a translational overview

Barbero-Becerra

López-Méndez

Romo‐Araiza

et al. 2020

Expert Review of Gastroenterology & Hepatology

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Editorial: putting more muscle into treating our chronic hepatitis B patients—the importance of assessing sarcopenia

Abstract: Linked Content This article is linked to Han et al paper. To view this article visit https://doi.org/10.1111/apt.14843.

Cited by 3 publications

References 8 publications

Editorial: Hepatitis C virus eradication improves skeletal muscle mass—Authors' reply

Editorial: Hepatitis C virus eradication improves skeletal muscle mass—Authors' reply

Influence of Methods Used to Establish Sarcopenia Cutoff Values for Skeletal Muscle Measures Using Unenhanced and Contrast‐Enhanced Computed Tomography Images

Sarcopenia in chronic liver diseases: a translational overview

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